Development Level

Tbio 30 | 11,445
Tchem 12 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 3 | 220
preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
increased prepulse inhibition 1 | 32
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
trunk curl 1 | 16

Disease

ovarian cancer 39 | 8,520
Carcinoma 24 | 11,493
Multiple myeloma 24 | 1,332
osteosarcoma 21 | 7,950
psoriasis 19 | 6,694
lung cancer 18 | 4,740
glioblastoma 16 | 5,792
Cancer 12 | 2,499
Breast cancer 11 | 3,578
HIV Infections 11 | 102
atypical teratoid / rhabdoid tumor 11 | 5,112
Waldenstrons macroglobulinemia 9 | 765
adult high grade glioma 9 | 3,801
dermatomyositis 9 | 966
ependymoma 9 | 4,679
malignant mesothelioma 9 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
medulloblastoma, large-cell 8 | 6,241
Astrocytoma, Pilocytic 7 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
lung carcinoma 7 | 2,843
subependymal giant cell astrocytoma 7 | 2,287
astrocytoma 6 | 1,146
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
Mantle cell lymphoma 5 | 23
Pick disease 5 | 1,894
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850
Hereditary hemorrhagic telangiectasia 4 | 13
Hypertensive disease 4 | 292
Increase in blood pressure 4 | 119
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
juvenile dermatomyositis 4 | 1,187
primary Sjogren syndrome 4 | 735
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Acquired scoliosis 3 | 281
Anemia 3 | 365
Autosomal recessive predisposition 3 | 1,442
Cardiomegaly 3 | 116
Congenital clubfoot 3 | 109
Craniofacial Abnormalities 3 | 151
Curvature of spine 3 | 282
Eye Abnormalities 3 | 35
Fibrodysplasia ossificans progressiva 3 | 17
Flexion contracture of proximal interphalangeal joint 3 | 75
Multiple synostoses syndrome 3 | 9
Primary pulmonary hypertension 3 | 14
active ulcerative colitis 3 | 764
cystic fibrosis 3 | 1,696
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
Abdominal Pain 2 | 98
Adenoma 2 | 167
Arachnodactyly 2 | 49
Atypical scarring of skin 2 | 62
Bilateral fifth finger clinodactyly 2 | 110
Blue sclera 2 | 32
Brachydactyly 2 | 156
Breast Neoplasms 2 | 445
Byzanthine arch palate 2 | 194
Chest Pain 2 | 38
Colorectal Neoplasms 2 | 243
Congestive heart failure 2 | 113
Coronary artery disease 2 | 268
Craniosynostosis 2 | 74
Curvature of little finger 2 | 110
Decreased joint mobility 2 | 53
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Gaucher disease type 1 2 | 180
Heart disease 2 | 306
Hemoglobin low 2 | 124
Hernia, Inguinal 2 | 89
Hypertension 2 | 396
Hypotrophic malar bone 2 | 129
Joint stiffness 2 | 84
Liver Cirrhosis 2 | 181
Malar flattening 2 | 129
Mammary Neoplasms 2 | 425
Microsatellite Instability 2 | 12
Osteoporosis 2 | 363
Pediatric failure to thrive 2 | 365
Seizures 2 | 596
Skull malformation 2 | 38
pulmonary arterial hypertension 2 | 75

Tissue

Blood and immune system 48 | 16,909
Cardiovascular System 48 | 15,192
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Nervous System 47 | 16,725

Target Family

Enzyme 36 | 4,145
Kinase 11 | 634
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Proteasome subunit alpha type-7 PSMA7 Tbio Enzyme -2.71627 496.7 288
Proteasome subunit alpha type-6 PSMA6 Tbio Enzyme -2.80973 614.4 288
26S proteasome non-ATPase regulatory subunit 11 PSMD11 Tbio Enzyme -1.13234 13.3 211
Bone morphogenetic protein receptor type-1B BMPR1B Tchem Kinase -2.00303 86.8 498
Proteasome subunit alpha type-3 PSMA3 Tbio Enzyme -1.20981 15.8 181
Proteasome subunit alpha type-4 PSMA4 Tbio Enzyme -1.01237
Proteasome subunit alpha type-2 PSMA2 Tbio Enzyme -0.82346 5.78 245