Development Level

Tbio 24 | 11,445
Tchem 11 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
cataract 3 | 92
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
decreased hematocrit 2 | 46
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
increased total body fat amoun... 2 | 134
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Cancer 31 | 2,499
Carcinoma 28 | 11,493
lung cancer 23 | 4,740
osteosarcoma 22 | 7,950
ovarian cancer 22 | 8,520
glioblastoma 18 | 5,792
atypical teratoid / rhabdoid tumor 17 | 5,112
Breast cancer 16 | 3,578
medulloblastoma, large-cell 16 | 6,241
psoriasis 16 | 6,694
ependymoma 14 | 4,679
Downward slant of palpebral fissure 13 | 158
Orbital separation excessive 13 | 244
group 3 medulloblastoma 13 | 4,104
Cryptorchidism 12 | 296
Hypoplastic mandible condyle 12 | 275
Kidney cancer 12 | 2,613
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
malignant mesothelioma 12 | 3,232
oligodendroglioma 12 | 2,850
Autosomal recessive predisposition 11 | 1,442
Byzanthine arch palate 11 | 194
Delayed bone age 11 | 136
Short stature 11 | 531
Strabismus 11 | 270
invasive ductal carcinoma 11 | 2,951
Blepharoptosis 10 | 231
Breast Neoplasms 10 | 445
High forehead 10 | 102
Mammary Neoplasms 10 | 425
Seizures 10 | 596
Tall forehead 10 | 102
Cleft Lip 9 | 141
Cleft Palate 9 | 271
Concave bridge of nose 9 | 195
Decreased projection of midface 9 | 105
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Exophthalmos 9 | 112
Frontal bossing 9 | 157
Hypogonadism, Isolated Hypogonadotropic 9 | 71
Hypogonadotropic hypogonadism 9 | 89
Hypotrophic midface 9 | 105
Joint hyperflexibility 9 | 78
Midface retrusion 9 | 105
Muscle hypotonia 9 | 571
Prominent eyes 9 | 96
Prominent globes 9 | 96
Protruding eyes 9 | 96
Small midface 9 | 105
Wide spaced nipples 9 | 46
astrocytic glioma 9 | 2,597
non-small cell lung cancer 9 | 2,890
Acquired scoliosis 8 | 281
Astrocytoma, Pilocytic 8 | 3,081
Cognitive delay 8 | 608
Curvature of spine 8 | 282
Depressive disorder 8 | 409
Dull intelligence 8 | 645
Epilepsy 8 | 792
Generalized osteopenia 8 | 99
Global developmental delay 8 | 608
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Low set ears 8 | 181
Low-set, posteriorly rotated ears 8 | 110
Lung Neoplasms 8 | 232
Melanocytic nevus 8 | 43
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Noncancerous mole 8 | 28
Noonan syndrome 8 | 34
Osteopenia 8 | 99
Pectus excavatum 8 | 100
Poor school performance 8 | 645
Schizophrenia 8 | 1,160
Telecanthus 8 | 62
breast carcinoma 8 | 1,638
interstitial cystitis 8 | 2,312
lung adenocarcinoma 8 | 2,716
lung carcinoma 8 | 2,843
Carcinoma, Hepatocellular 7 | 228
Congenital Epicanthus 7 | 177
Craniosynostosis 7 | 74
Feeding difficulties in infancy 7 | 175
Hepatomegaly 7 | 285
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Liver carcinoma 7 | 240
Short neck 7 | 140
Triangular face 7 | 58
adult high grade glioma 7 | 3,801
colon cancer 7 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 1,819

Tissue

Endocrine System 43 | 18,159
Digestive Tract 41 | 17,369
Nervous System 41 | 16,725
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Blood and immune system 39 | 16,909
Respiratory system 38 | 16,393
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 27 | 12,091
Kinase 12 | 634
Enzyme 5 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.92119 9.61 156
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.07061 109.8 192