Development Level

Tbio 16 | 11,445
Tchem 3 | 1,598

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal heart morphology 2 | 162
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal forelimb morphology 1 | 2
abnormal response to tactile s... 1 | 17
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased circulating insulin ... 1 | 3
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
syndactyly 1 | 23

Disease

Carcinoma 17 | 11,493
psoriasis 13 | 6,694
atypical teratoid / rhabdoid tumor 12 | 5,112
osteosarcoma 12 | 7,950
ovarian cancer 12 | 8,520
Breast cancer 11 | 3,578
ependymoma 11 | 4,679
lung cancer 9 | 4,740
Cancer 8 | 2,499
Kidney cancer 8 | 2,613
glioblastoma 8 | 5,792
interstitial cystitis 8 | 2,312
medulloblastoma, large-cell 8 | 6,241
primitive neuroectodermal tumor 7 | 3,035
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 4,104
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
pediatric high grade glioma 6 | 1,064
Bipolar Disorder 5 | 666
acute myeloid leukemia 5 | 783
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
Astrocytoma, Pilocytic 4 | 3,081
Cryptorchidism 4 | 296
Decreased projection of maxilla 4 | 66
Deficiency of upper jaw bones 4 | 66
Hypoplasia of the maxilla 4 | 66
Hypotrophic maxilla 4 | 66
Maxillary retrognathia 4 | 66
Pick disease 4 | 1,894
Retrusion of upper jaw bones 4 | 66
Schizophrenia 4 | 1,160
Short stature 4 | 531
Small head 4 | 374
cystic fibrosis 4 | 1,696
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
Angle class 2 malocclusion 3 | 57
Angle class 3 malocclusion 3 | 57
Autistic Disorder 3 | 364
Bushy eyebrows 3 | 49
Cataract 3 | 297
Colonic Neoplasms 3 | 142
Colorectal Neoplasms 3 | 243
Congenital deafness 3 | 185
Congenital ocular coloboma (disorder) 3 | 40
Craniofacial Abnormalities 3 | 151
Deafness 3 | 198
Dull intelligence 3 | 645
Endometrial cancer 3 | 311
Enophthalmos 3 | 75
Epilepsy 3 | 792
Exudative vitreoretinopathy 3 | 15
Failure to gain weight 3 | 365
Frontal bossing 3 | 157
Hearing Loss, Partial 3 | 185
Hypoplastic iliac wing 3 | 19
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Lens Opacities 3 | 231
Low intelligence 3 | 645
Low set ears 3 | 181
Malocclusion 3 | 57
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Microstomia 3 | 78
Muscle hypotonia 3 | 571
Orbital separation excessive 3 | 244
Patent ductus arteriosus 3 | 90
Pediatric failure to thrive 3 | 365
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Strabismus 3 | 270
Sunken eyes 3 | 63
Syndactyly 3 | 88
Ventricular Septal Defects 3 | 119
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
hearing impairment 3 | 199
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
non primary Sjogren syndrome sicca 3 | 891
osteoporosis-pseudoglioma syndrome 3 | 9
pancreatic cancer 3 | 2,398
subependymal giant cell astrocytoma 3 | 2,287
Agoraphobia 2 | 21
Auricular malformation 2 | 41
Large foramen magnum 2 | 6
Poor coordination 2 | 11
Retinal Neovascularization 2 | 4
Simple ear 2 | 41

Tissue

Blood and immune system 19 | 16,909
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Skin and soft tissues 19 | 17,230
Cardiovascular System 18 | 15,192
Liver and Pancreas 18 | 16,750
Respiratory system 18 | 16,393
Urinary Tract 18 | 16,678

Target Family

GPCR 10 | 408
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
Non-IDG 2 | 12,091

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 236 | 236
http://pathwaycommons.org/pc2/... 235 | 235
http://pathwaycommons.org/pc2/... 233 | 233
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http://pathwaycommons.org/pc2/... 178 | 178
http://pathwaycommons.org/pc2/... 173 | 173
http://pathwaycommons.org/pc2/... 173 | 173
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http://pathwaycommons.org/pc2/... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307
Frizzled-1 FZD1 Tbio GPCR -2.07049 78.4 286
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.20549 17.1 109
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591