Development Level

Tchem 6 | 1,598
Tclin 6 | 613
Tbio 2 | 11,445

IMPC Phenotype

decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
abnormal bone mineralization 1 | 38
abnormal glucose homeostasis 1 | 4
decreased T cell number 1 | 15
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
increased CD4-positive, alpha ... 1 | 4
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
thrombocytosis 1 | 27

Disease

Carcinoma 13 | 11,493
Cancer 12 | 2,499
ovarian cancer 11 | 8,520
osteosarcoma 9 | 7,950
lung cancer 8 | 4,740
psoriasis 8 | 6,694
glioblastoma 7 | 5,792
interstitial cystitis 7 | 2,312
medulloblastoma, large-cell 7 | 6,241
invasive ductal carcinoma 6 | 2,951
ulcerative colitis 6 | 1,819
Epilepsy 5 | 792
Schizophrenia 5 | 1,160
Seizures 5 | 596
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Big calvaria 4 | 147
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Diffuse large B-cell lymphoma 4 | 39
Hypersensitivity reaction type II disease 4 | 253
Immunologic Deficiency Syndromes 4 | 113
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Kidney cancer 4 | 2,613
Lymphoma, Large B-Cell, Diffuse 4 | 34
Mammary Neoplasms 4 | 425
Microstomia 4 | 78
Orbital separation excessive 4 | 244
Rheumatoid arthritis 4 | 1,191
Splenomegaly 4 | 190
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
juvenile dermatomyositis 4 | 1,187
primary Sjogren syndrome 4 | 735
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Arthritis 3 | 290
Asthma 3 | 385
Bipolar Disorder 3 | 666
Cataract 3 | 297
Cognitive delay 3 | 608
Congenital hemihypertrophy 3 | 6
Dull intelligence 3 | 645
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Frontal bossing 3 | 157
Global developmental delay 3 | 608
Gynecomastia 3 | 64
High forehead 3 | 102
Hydrocephalus 3 | 152
Hyperkyphosis 3 | 111
Hypoplastic mandible condyle 3 | 275
Infantile onset 3 | 238
Inflammatory bowel disease 3 | 151
Influenza 3 | 142
Intellectual disability 3 | 1,016
Kyphosis deformity of spine 3 | 114
Lens Opacities 3 | 231
Low intelligence 3 | 645
Macrocephaly 3 | 11
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Micrognathism 3 | 275
Myopia 3 | 176
Palmoplantar keratosis 3 | 74
Pediatric failure to thrive 3 | 365
Polydactyly 3 | 107
Polymicrogyria 3 | 48
Poor school performance 3 | 645
Primary immunodeficiency disease 3 | 54
Prostatic Neoplasms 3 | 495
Proteus syndrome 3 | 6
Renal Cell Carcinoma 3 | 214
Stomach Neoplasms 3 | 300
Tall forehead 3 | 102
Telecanthus 3 | 62
Ventricular Septal Defects 3 | 119
Waldenstrons macroglobulinemia 3 | 765
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
follicular lymphoma 3 | 20
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
nasopharyngeal carcinoma 3 | 1,058
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035

Tissue

Blood and immune system 14 | 16,909
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678
Cardiovascular System 13 | 15,192

Target Family

Kinase 10 | 634
Non-IDG 3 | 12,091
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.12025 204.9 608
T-cell-specific surface glycoprotein CD28 CD28 Tbio Non-IDG -1.96865 108.8 1508
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD Tclin Kinase -2.85064 709.2 423
Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 Tbio Enzyme -1.80666 60.0 432
Tyrosine-protein kinase Lck LCK Tclin Kinase -3.17774 1500.3 1180
Tyrosine-protein kinase Fyn FYN Tclin Kinase -3.03132 1021.2 726
T-lymphocyte activation antigen CD86 CD86 Tclin Non-IDG -3.48463 2838.9 1288
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PIK3CB Tchem Kinase -2.29043 197.8 384