Development Level

Tchem 129 | 1,388
Tbio 62 | 11,651
Tclin 42 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 11 | 125
RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 14 | 499
embryonic lethality prior to t... 10 | 278
abnormal bone structure 9 | 187
abnormal embryo size 9 | 220
embryonic lethality prior to o... 8 | 239
decreased vertical activity 5 | 208
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
enlarged heart 4 | 210
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal skin morphology 3 | 50
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased mean corpuscular vol... 3 | 79
enlarged spleen 3 | 41
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal vibrissa morphology 2 | 25
anophthalmia 2 | 33
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating iron lev... 2 | 32
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
edema 2 | 59
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased mean platelet volume 2 | 45
male infertility 2 | 123
microphthalmia 2 | 26
pale yolk sac 2 | 25
pallor 2 | 34
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytosis 2 | 27
tremors 2 | 39
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
brachydactyly 1 | 19
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged thymus 1 | 5
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
limb grasping 1 | 41
shortened RR interval 1 | 17
thin ventricular wall 1 | 24
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 182 | 11,493
ovarian cancer 148 | 8,520
osteosarcoma 133 | 7,950
glioblastoma 117 | 5,792
Cancer 113 | 2,499
psoriasis 104 | 6,694
medulloblastoma, large-cell 102 | 6,241
atypical teratoid / rhabdoid tumor 91 | 5,112
lung cancer 91 | 4,740
ependymoma 79 | 4,679
adult high grade glioma 73 | 3,801
malignant mesothelioma 68 | 3,232
Astrocytoma, Pilocytic 64 | 3,081
group 3 medulloblastoma 64 | 4,104
Breast cancer 61 | 3,578
Kidney cancer 59 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 58 | 3,291
oligodendroglioma 55 | 2,850
primitive neuroectodermal tumor 55 | 3,035
non-small cell lung cancer 53 | 2,890
lung carcinoma 51 | 2,843
astrocytic glioma 43 | 2,597
invasive ductal carcinoma 43 | 2,951
subependymal giant cell astrocytoma 43 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
tuberculosis 41 | 2,010
Multiple myeloma 37 | 1,332
lung adenocarcinoma 37 | 2,716
Schizophrenia 35 | 1,160
diabetes mellitus 35 | 1,728
ulcerative colitis 35 | 1,819
interstitial cystitis 34 | 2,312
pancreatic cancer 33 | 2,398
Pick disease 31 | 1,894
Alzheimer's disease 30 | 658
Autosomal recessive predisposition 30 | 1,442
adrenocortical carcinoma 30 | 1,428
group 4 medulloblastoma 28 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Rheumatoid arthritis 26 | 1,191
astrocytoma 26 | 1,146
cystic fibrosis 26 | 1,696
pituitary cancer 26 | 1,972
Renal Cell Carcinoma 25 | 214
colon cancer 25 | 1,478
breast carcinoma 24 | 1,638
Breast Neoplasms 23 | 445
Mammary Neoplasms 23 | 425
Bipolar Disorder 21 | 666
Intellectual disability 21 | 1,016
Obesity 20 | 678
Waldenstrons macroglobulinemia 20 | 765
primary Sjogren syndrome 20 | 735
Depressive disorder 19 | 409
Liver Cirrhosis, Experimental 19 | 769
Short stature 19 | 531
Vascular disease 19 | 319
ductal carcinoma in situ 19 | 1,745
juvenile dermatomyositis 19 | 1,187
Melanoma 18 | 711
Stomach Neoplasms 18 | 300
Parkinson's disease 17 | 392
Prostatic Neoplasms 17 | 495
cutaneous lupus erythematosus 17 | 1,057
dermatomyositis 17 | 966
Dull intelligence 16 | 645
Epilepsy 16 | 792
Low intelligence 16 | 645
Lung Neoplasms 16 | 232
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Seizures 16 | 596
spina bifida 16 | 1,074
Hypertensive disease 15 | 292
Orbital separation excessive 15 | 244
acute myeloid leukemia 15 | 783
pediatric high grade glioma 15 | 1,064
primary pancreatic ductal adenocarcinoma 15 | 1,109
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Hamman-Rich syndrome 14 | 34
Hypertension 14 | 396
Mental and motor retardation 14 | 608
active Crohn's disease 14 | 922
acute quadriplegic myopathy 14 | 1,158
non primary Sjogren syndrome sicca 14 | 891
Acquired scoliosis 13 | 281
Asthma 13 | 385
Atopic dermatitis 13 | 952
Byzanthine arch palate 13 | 194
Curvature of spine 13 | 282
Heart disease 13 | 306
Major Depressive Disorder 13 | 301
Mental Depression 13 | 333
Skin cancer 13 | 469
Toxic encephalopathy 13 | 141
active ulcerative colitis 13 | 764
esophageal adenocarcinoma 13 | 737

Tissue

Endocrine System 236 | 18,159
Digestive Tract 234 | 17,369
Male tissues 234 | 17,142
Skin and soft tissues 234 | 17,230
Female tissues 232 | 17,400
Blood and immune system 231 | 16,909
Liver and Pancreas 231 | 16,750
Urinary Tract 231 | 16,678
Nervous System 228 | 16,725
Cardiovascular System 227 | 15,192
Respiratory system 227 | 16,393

Target Family

Kinase 160 | 634
Enzyme 69 | 4,145
Non-IDG 7 | 12,091

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610