Development Level

Tchem 10 | 1,598
Tbio 9 | 11,445

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased vertical activity 2 | 208
abnormal eating behavior 1 | 1
abnormal forced expiratory flo... 1 | 1
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased tidal volume 1 | 1
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
preweaning lethality, incomple... 1 | 499
respiratory system phenotype 1 | 2

Disease

Carcinoma 18 | 11,493
Cancer 15 | 2,499
ovarian cancer 11 | 8,520
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
lung cancer 10 | 4,740
osteosarcoma 10 | 7,950
psoriasis 10 | 6,694
Breast cancer 9 | 3,578
glioblastoma 9 | 5,792
Astrocytoma, Pilocytic 8 | 3,081
medulloblastoma, large-cell 8 | 6,241
Alzheimer's disease 7 | 658
Failure to gain weight 7 | 365
Kidney cancer 7 | 2,613
Pediatric failure to thrive 7 | 365
Schizophrenia 7 | 1,160
primitive neuroectodermal tumor 7 | 3,035
Carcinoma, Squamous Cell 6 | 110
Cataract 6 | 297
Dementia 6 | 175
Lens Opacities 6 | 231
Strabismus 6 | 270
astrocytic glioma 6 | 2,597
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
juvenile dermatomyositis 6 | 1,187
oligodendroglioma 6 | 2,850
pediatric high grade glioma 6 | 1,064
Acquired scoliosis 5 | 281
Adenoid Cystic Carcinoma 5 | 99
Brachydactyly 5 | 156
Carcinoma, Adenoid Cystic 5 | 99
Carcinoma, Pancreatic Ductal 5 | 20
Cerebrovascular disease 5 | 238
Cryptorchidism 5 | 296
Curvature of spine 5 | 282
Esophageal Squamous Cell Carcinoma 5 | 77
Neurodegenerative disease 5 | 414
Short distal phalanges 5 | 50
Short stature 5 | 531
Squamous cell carcinoma of esophagus 5 | 77
Syndactyly 5 | 88
adult high grade glioma 5 | 3,801
astrocytoma 5 | 1,146
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
Alagille syndrome 4 | 15
Atrial Septal Defects 4 | 85
Bipolar Disorder 4 | 666
Byzanthine arch palate 4 | 194
Cadasil 4 | 10
Craniofacial Abnormalities 4 | 151
Crohn's disease 4 | 321
Deafness 4 | 198
Downward slant of palpebral fissure 4 | 158
Epilepsy 4 | 792
Hydrocephalus 4 | 152
Hypoplastic mandible condyle 4 | 275
Immune system cancer 4 | 140
Liver cancer 4 | 604
Low set ears 4 | 181
Lymphoid leukemia 4 | 160
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Patent ductus arteriosus 4 | 90
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Skin Neoplasms 4 | 69
Tetralogy of Fallot 4 | 63
Ventricular Septal Defects 4 | 119
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Bilateral fifth finger clinodactyly 3 | 110
Blepharoptosis 3 | 231
Congenital Epicanthus 3 | 177
Congenital dislocation of radial head 3 | 14
Curvature of little finger 3 | 110
Down syndrome 3 | 499
Electroencephalogram abnormal 3 | 101
Exophthalmos 3 | 112
Hypertension 3 | 396
Isolated cases 3 | 72
Liver Cirrhosis 3 | 181
Long narrow head 3 | 75
Lung Neoplasms 3 | 232
Microstomia 3 | 78
Multiple Sclerosis 3 | 540
Pectus excavatum 3 | 100
Prominent eyes 3 | 96
Prominent globes 3 | 96
Protruding eyes 3 | 96
Skin cancer 3 | 469
Sparse hair 3 | 59
Thin, sparse hair 3 | 59
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 19 | 16,909
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Cardiovascular System 18 | 15,192
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 12 | 12,091
Enzyme 4 | 4,145
Epigenetic 2 | 242
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 236 | 236
http://pathwaycommons.org/pc2/... 235 | 235
http://pathwaycommons.org/pc2/... 233 | 233
http://pathwaycommons.org/pc2/... 224 | 224
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http://pathwaycommons.org/pc2/... 223 | 223
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http://pathwaycommons.org/pc2/... 178 | 178
http://pathwaycommons.org/pc2/... 173 | 173
http://pathwaycommons.org/pc2/... 173 | 173
http://pathwaycommons.org/pc2/... 123 | 123
http://pathwaycommons.org/pc2/... 96 | 96
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 63 | 63
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http://pathwaycommons.org/pc2/... 19 | 19
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http://pathwaycommons.org/pc2/... 19 | 19
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http://pathwaycommons.org/pc2/... 16 | 16
http://pathwaycommons.org/pc2/... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Tchem Enzyme -2.64652 422.4 384
Neurogenic locus notch homolog protein 4 NOTCH4 Tchem Non-IDG -2.75010 557.0 225
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
Disintegrin and metalloproteinase domain-containing protein 17 ADAM17 Tchem Enzyme -3.55216 3569.0 718
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499
Presenilin-2 PSEN2 Tchem Enzyme -2.78856 585.9 310
Mastermind-like protein 2 MAML2 Tbio Non-IDG -1.82854 72.4 136
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775