Development Level

Tbio 7 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
increased heart left ventricle... 1 | 4
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 8 | 11,493
Cancer 5 | 2,499
ovarian cancer 5 | 8,520
Short stature 4 | 531
ependymoma 4 | 4,679
medulloblastoma, large-cell 4 | 6,241
oligodendroglioma 4 | 2,850
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Blepharoptosis 3 | 231
Bowed and upward slanting eyebrows 3 | 41
Kidney cancer 3 | 2,613
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Macrotia 3 | 87
Muscle hypotonia 3 | 571
Osteoporosis 3 | 363
Pick disease 3 | 1,894
Small head 3 | 374
Thick, flared eyebrows 3 | 41
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
group 4 medulloblastoma 3 | 1,855
lung adenocarcinoma 3 | 2,716
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Abnormal dermatoglyphic pattern 2 | 24
Acquired scoliosis 2 | 281
Aortic coarctation 2 | 30
Butterfly vertebrae 2 | 7
Byzanthine arch palate 2 | 194
COPD 2 | 118
Carney complex 2 | 25
Cerebral atrophy 2 | 178
Cholangiocarcinoma 2 | 35
Cleft Palate 2 | 271
Cognitive delay 2 | 608
Conductive hearing loss 2 | 123
Congenital hemivertebra 2 | 25
Curvature of spine 2 | 282
Decreased size of teeth 2 | 62
Decreased width of tooth 2 | 59
Dilated ventricles (finding) 2 | 121
Eversion of lateral third of lower eyelids 2 | 4
Failure to gain weight 2 | 365
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Heart Septal Defects 2 | 24
Hemangioma 2 | 69
Hydrocephalus 2 | 152
Hypodontia 2 | 81
Hypoplasia of columella 2 | 7
Joint hyperflexibility 2 | 78
Kabuki make-up syndrome 2 | 4
Kabuki syndrome 2 | 27
Kidney disease 2 | 430
Laterally sparse eyebrows 2 | 12
Long eyelashes 2 | 37
Mental and motor retardation 2 | 608
Microdontia (disorder) 2 | 59
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Prominent ear 2 | 56
Protruding ears 2 | 56
Recurrent infections 2 | 48
Sensorineural Hearing Loss (disorder) 2 | 284
Short columella 2 | 7
Short fifth finger 2 | 9
Short middle phalanges 2 | 12
Strabismus 2 | 270
Uranostaphyloschisis 2 | 167
Widely spaced teeth 2 | 31
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
non-small cell lung cancer 2 | 2,890
Carcinoma of colon 1 | 32
Cardiomegaly 1 | 116
Developmental Disabilities 1 | 23
DiGeorge syndrome 1 | 47
Enophthalmos 1 | 75
Generalized osteopenia 1 | 99
Growth Disorders 1 | 35
Hirsutism 1 | 47
Juvenile Myelomonocytic Leukemia 1 | 21
Language Disorders 1 | 13
Mitral valve insufficiency 1 | 49
Osteopenia 1 | 99
Renal Cell Carcinoma 1 | 214
Spontaneous haematoma 1 | 8
Sunken eyes 1 | 63
Tetralogy of Fallot 1 | 63
Velocardiofacial syndrome 1 | 46

Tissue

Endocrine System 11 | 18,159
Male tissues 11 | 17,142
Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 5 | 4,145
Kinase 4 | 634
Non-IDG 2 | 12,091

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 236 | 236
http://pathwaycommons.org/pc2/... 235 | 235
http://pathwaycommons.org/pc2/... 233 | 233
http://pathwaycommons.org/pc2/... 224 | 224
http://pathwaycommons.org/pc2/... 224 | 224
http://pathwaycommons.org/pc2/... 223 | 223
http://pathwaycommons.org/pc2/... 223 | 223
http://pathwaycommons.org/pc2/... 183 | 183
http://pathwaycommons.org/pc2/... 178 | 178
http://pathwaycommons.org/pc2/... 173 | 173
http://pathwaycommons.org/pc2/... 173 | 173
http://pathwaycommons.org/pc2/... 123 | 123
http://pathwaycommons.org/pc2/... 96 | 96
http://pathwaycommons.org/pc2/... 85 | 85
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
E3 ubiquitin-protein ligase CBL-C CBLC Tbio Enzyme -0.55931 2.63 246
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Ras-related protein Rap-1A RAP1A Tchem Enzyme -2.40799 294.7 329
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Crk-like protein CRKL Tbio Non-IDG -2.20025 160.0 521
E3 ubiquitin-protein ligase CBL CBL Tbio Enzyme -2.54239 328.5 827
cAMP-dependent protein kinase catalytic subunit gamma PRKACG Tbio Kinase -0.68977 4.71 126