Development Level

Tbio 1 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74

Disease

Autoimmune lymphoproliferative syndrome 2 | 11
Autosomal recessive predisposition 2 | 1,442
Cancer 2 | 2,499
glioblastoma 2 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
ovarian cancer 2 | 8,520
psoriasis 2 | 6,694
Adenocarcinoma 1 | 122
Asthma 1 | 385
Astrocytoma, Pilocytic 1 | 3,081
Autoimmune lymphoproliferative syndrome type 2B 1 | 9
Bipolar Disorder 1 | 666
Breast Neoplasms 1 | 445
Breast cancer 1 | 3,578
Carcinoma 1 | 11,493
Carcinoma, Hepatocellular 1 | 228
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, squamous cell of head and neck 1 | 31
Caspase-8 deficiency 1 | 1
Cerebral Hemorrhage 1 | 42
Cerebral atrophy 1 | 178
Chronic diarrhea 1 | 29
Colorectal Neoplasms 1 | 243
Congenital atresia of pulmonary artery 1 | 5
Contact Dermatitis 1 | 81
Craniofacial Abnormalities 1 | 151
Decreased T cell activation 1 | 4
Decreased liver function 1 | 24
Defective B cell activation 1 | 1
Degenerative brain disorder 1 | 100
Dermatitis, Allergic Contact 1 | 67
Dermatitis, Contact 1 | 71
Diabetes Mellitus, Non-Insulin-Dependent 1 | 145
Diabetes Mellitus, Type 2 1 | 142
Eczema 1 | 45
Edema 1 | 81
Encephalopathies 1 | 43
Epilepsy 1 | 792
Esophageal Neoplasms 1 | 69
Failure to gain weight 1 | 365
Hearing Loss, Sensorineural 1 | 11
INFECTIONS, RECURRENT, WITH ENCEPHALOPATHY, HEPATIC DYSFUNCTION, AND CARDIOVASCULAR MALFORMATIONS 1 | 1
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Kidney cancer 1 | 2,613
Liver Dysfunction 1 | 99
Liver carcinoma 1 | 240
Liver dysfunction, mild 1 | 24
Lung Neoplasms 1 | 232
Lymphadenopathy 1 | 62
Mammary Neoplasms 1 | 425
Melanoma 1 | 711
Micronodular cirrhosis 1 | 12
Myocardial Reperfusion Injury 1 | 37
Neoplasm Metastasis 1 | 168
Neurodegenerative disease 1 | 414
Oculootodental Syndrome 1 | 2
Otodental Dysplasia 1 | 2
Papillomavirus Infections 1 | 3
Pediatric failure to thrive 1 | 365
Pneumonia 1 | 174
Precursor Cell Lymphoblastic Leukemia Lymphoma 1 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 | 49
Reactive airway disease 1 | 21
Recurrent infections 1 | 48
Recurrent sinopulmonary infections 1 | 6
Reperfusion Injury 1 | 86
Seizures 1 | 596
Sensorineural Hearing Loss (disorder) 1 | 284
Short stature 1 | 531
Skin Neoplasms 1 | 69
Somatic mutation 1 | 61
Splenomegaly 1 | 190
Squamous cell carcinoma of the head and neck 1 | 29
Status Epilepticus 1 | 98
Stomach Neoplasms 1 | 300
Stomach cancer 1 | 30
Stomatognathic Diseases 1 | 2
Subacute progressive viral hepatitis 1 | 9
Supratentorial atrophy 1 | 94
Toxic encephalopathy 1 | 141
Type 2 diabetes mellitus 1 | 272
Uterine Cervical Neoplasm 1 | 25
Uterine Cervical Neoplasms 1 | 26
Vascular disease 1 | 319
Ventricular Septal Defects 1 | 119
adult high grade glioma 1 | 3,801
atypical teratoid / rhabdoid tumor 1 | 5,112
breast carcinoma 1 | 1,638
cutaneous lupus erythematosus 1 | 1,057
ependymoma 1 | 4,679
esophageal cancer 1 | 22
hepatocellular carcinoma 1 | 547
lung cancer 1 | 4,740
lung carcinoma 1 | 2,843
non-small cell lung carcinoma 1 | 317
osteosarcoma 1 | 7,950
primary Sjogren syndrome 1 | 735
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Enzyme 1 | 4,145
Non-IDG 1 | 12,091

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 2 | 2
http://pathwaycommons.org/pc2/... 236 | 236
http://pathwaycommons.org/pc2/... 235 | 235
http://pathwaycommons.org/pc2/... 233 | 233
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http://pathwaycommons.org/pc2/... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
FAS-associated death domain protein FADD Tbio Non-IDG -2.70083 469.8 708