Development Level

Tbio 15 | 11,445
Tchem 13 | 1,598
Tclin 8 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal eye morphology 2 | 68
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
increased circulating triglyce... 2 | 42
microphthalmia 2 | 26
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal pericardium morpholog... 1 | 26
abnormal spleen morphology 1 | 55
cataract 1 | 92
convulsive seizures 1 | 13
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased startle reflex 1 | 75
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating insulin ... 1 | 3
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased mean platelet volume 1 | 45
limb grasping 1 | 41
mydriasis 1 | 6
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

Carcinoma 30 | 11,493
atypical teratoid / rhabdoid tumor 17 | 5,112
psoriasis 17 | 6,694
Schizophrenia 16 | 1,160
ependymoma 15 | 4,679
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
osteosarcoma 15 | 7,950
group 3 medulloblastoma 14 | 4,104
lung cancer 12 | 4,740
ovarian cancer 12 | 8,520
Alcoholic Intoxication, Chronic 11 | 289
Bipolar Disorder 11 | 666
lung carcinoma 10 | 2,843
primitive neuroectodermal tumor 10 | 3,035
Attention deficit hyperactivity disorder 9 | 278
Breast cancer 9 | 3,578
Depressive disorder 9 | 409
Kidney cancer 9 | 2,613
Parkinson's disease 9 | 392
astrocytic glioma 9 | 2,597
oligodendroglioma 9 | 2,850
Mental Depression 8 | 333
Mood Disorders 8 | 184
adult high grade glioma 8 | 3,801
non-small cell lung cancer 8 | 2,890
Alcohol dependence 7 | 107
Astrocytoma, Pilocytic 7 | 3,081
Attention Deficit Disorder with Hyperactivity 7 | 21
Major Depressive Disorder 7 | 301
Unipolar Depression 7 | 250
Amphetamine-Related Disorders 6 | 74
Autistic Disorder 6 | 364
Cancer 6 | 2,499
Epilepsy 6 | 792
interstitial cystitis 6 | 2,312
Asthma 5 | 385
Epilepsy, Temporal Lobe 5 | 23
Hypertension 5 | 396
Hypotension 5 | 82
Intellectual disability 5 | 1,016
Migraine 5 | 83
Pain 5 | 103
Seizures 5 | 596
Substance abuse 5 | 59
Vascular disease 5 | 319
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung adenocarcinoma 5 | 2,716
malignant mesothelioma 5 | 3,232
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287
Allergic rhinitis 4 | 94
Autosomal recessive predisposition 4 | 1,442
Cocaine-Related Disorders 4 | 92
Dysmenorrhea 4 | 21
Gilles de la Tourette syndrome 4 | 47
Huntington's disease 4 | 76
Hyperactive behavior 4 | 91
Hyperkinesis 4 | 32
Hypertensive disease 4 | 292
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Melanoma 4 | 711
Movement Disorders 4 | 55
Nasal congestion 4 | 21
Nasal discharge 4 | 24
Pathological gambling 4 | 15
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
Skin cancer 4 | 469
Substance Withdrawal Syndrome 4 | 55
Toxic encephalopathy 4 | 141
acute myeloid leukemia 4 | 783
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
invasive ductal carcinoma 4 | 2,951
pediatric high grade glioma 4 | 1,064
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Acromegaly 3 | 51
Anxiety Disorders 3 | 38
Bronchitis 3 | 43
Chronic schizophrenia 3 | 16
Common cold 3 | 67
Dyskinesia, Drug-Induced 3 | 15
Heroin dependence 3 | 30
Neoplasm Metastasis 3 | 168
Pulmonary emphysema 3 | 48
Spasticity 3 | 26
Substance-Related Disorders 3 | 115
Tremor 3 | 113
active Crohn's disease 3 | 922
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 559
obsessive-compulsive disorder 3 | 61
pancreatic cancer 3 | 2,398

Tissue

Endocrine System 36 | 18,159
Female tissues 35 | 17,400
Nervous System 33 | 16,725
Skin and soft tissues 33 | 17,230
Digestive Tract 32 | 17,369
Male tissues 32 | 17,142
Blood and immune system 30 | 16,909
Liver and Pancreas 30 | 16,750
Respiratory system 30 | 16,393
Urinary Tract 29 | 16,678
Cardiovascular System 25 | 15,192

Target Family

GPCR 31 | 408
Non-IDG 5 | 12,091

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.87313 723.9 643
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
D(1A) dopamine receptor DRD1 Tclin GPCR -2.55049 294.2 485
Metabotropic glutamate receptor 8 GRM8 Tchem GPCR -1.95032 89.4 286