Development Level

Tbio 7 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
decreased bone mineral content 2 | 151
increased eosinophil cell numb... 2 | 11
increased large unstained cell... 2 | 5
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal esophagus morphology 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 12
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased basophil cell number 1 | 7
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Cancer 11 | 2,499
psoriasis 11 | 6,694
glioblastoma 9 | 5,792
ovarian cancer 9 | 8,520
Carcinoma 8 | 11,493
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung cancer 6 | 4,740
osteosarcoma 6 | 7,950
Astrocytoma, Pilocytic 5 | 3,081
Vascular disease 5 | 319
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
Bipolar Disorder 4 | 666
Chemical and Drug Induced Liver Injury 4 | 195
Diabetes Mellitus, Experimental 4 | 108
group 3 medulloblastoma 4 | 4,104
hepatocellular carcinoma 4 | 547
spina bifida 4 | 1,074
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Autoimmune lymphoproliferative syndrome type 2B 3 | 9
Brain Ischemia 3 | 110
Breast Neoplasms 3 | 445
Carcinoma, Hepatocellular 3 | 228
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Edema 3 | 81
Fatty Liver 3 | 70
Hypersensitivity reaction type II disease 3 | 253
Kidney disease 3 | 430
Liver carcinoma 3 | 240
Mammary Neoplasms 3 | 425
Melanoma 3 | 711
Pick disease 3 | 1,894
Pneumonia 3 | 174
Schizophrenia 3 | 1,160
Stomach Neoplasms 3 | 300
Toxic encephalopathy 3 | 141
adrenocortical carcinoma 3 | 1,428
adult high grade glioma 3 | 3,801
aldosterone-producing adenoma 3 | 665
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
oligodendroglioma 3 | 2,850
ulcerative colitis 3 | 1,819
Acute kidney injury 2 | 70
Alzheimer Disease 2 | 83
Cardiomyopathies 2 | 110
Colonic Neoplasms 2 | 142
Colorectal Neoplasms 2 | 243
Depressive disorder 2 | 409
Dermatitis, Allergic Contact 2 | 67
Diarrhea 2 | 253
Esophageal Neoplasms 2 | 69
Fever 2 | 138
Heart disease 2 | 306
Heart failure 2 | 162
Hypersensitivity 2 | 63
Inflammatory bowel disease 2 | 151
Leukemia 2 | 104
Liver disease 2 | 237
Lung Neoplasms 2 | 232
Lung disease 2 | 142
Lymphadenopathy 2 | 62
Mental Depression 2 | 333
Multiple Sclerosis 2 | 540
Myocardial Infarction 2 | 151
Neoplasm Metastasis 2 | 168
Nerve Degeneration 2 | 121
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Parkinson Disease 2 | 64
Parkinson's disease 2 | 392
Polycystic ovary syndrome 2 | 360
Reperfusion Injury 2 | 86
Status Epilepticus 2 | 98
Thrombocytopenia 2 | 197
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
medulloblastoma 2 | 720
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
sarcoidosis 2 | 370
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 9 | 12,091
Kinase 4 | 634
Enzyme 2 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Mitogen-activated protein kinase kinase kinase 5 MAP3K5 Tchem Kinase -2.66223 525.4 1185
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.22748 161.7 603
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Receptor-interacting serine/threonine-protein kinase 2 RIPK2 Tchem Kinase -2.03990 107.3 474
CASP8 and FADD-like apoptosis regulator CFLAR Tbio Non-IDG -2.89793 871.7 683
Tumor necrosis factor TNF Tclin Non-IDG -4.71806 50345.6 2958
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.90485 75.1 549
Tumor necrosis factor receptor type 1-associated DEATH domain protein TRADD Tbio Non-IDG -2.04155 97.1 383