Development Level

Tchem 7 | 1,598
Tclin 2 | 613
Tbio 1 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
cataract 1 | 92
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

malignant mesothelioma 7 | 3,232
ovarian cancer 7 | 8,520
Carcinoma 5 | 11,493
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Porokeratosis of Mibelli 4 | 4
active Crohn's disease 4 | 922
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
Disseminated superficial actinic porokeratosis 3 | 4
Pick disease 3 | 1,894
Porokeratosis, Disseminated Superficial Actinic 3 | 4
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
medulloblastoma, large-cell 3 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Aplasia/Hypoplasia of the skin 2 | 16
Atherosclerosis 2 | 291
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Carcinoma, Hepatocellular 2 | 228
Cataract 2 | 297
Cognitive delay 2 | 608
Decreased platelet count 2 | 111
Downward slant of palpebral fissure 2 | 158
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Hyperkeratosis 2 | 50
Intellectual disability 2 | 1,016
Keratosis 2 | 37
Lens Opacities 2 | 231
Liver Cirrhosis, Experimental 2 | 769
Liver carcinoma 2 | 240
Mental and motor retardation 2 | 608
Mevalonic aciduria 2 | 16
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Osteoporosis 2 | 363
Pediatric failure to thrive 2 | 365
Photosensitivity of skin 2 | 51
Pruritus 2 | 58
Seizures 2 | 596
Small head 2 | 374
Thrombocytopenia 2 | 197
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
ependymoma 2 | 4,679
gastric cancer 2 | 459
hepatocellular carcinoma 2 | 547
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
pancreatic cancer 2 | 2,398
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
Antley-Bixler syndrome 1 | 16
Aphthous stomatitis 1 | 16
Brucellosis 1 | 24
Cerebral calcification 1 | 43
Chromosome Breakage 1 | 36
Cloudy cornea 1 | 33
Congenital ichthyosiform erythroderma 1 | 28
Corneal stromal opacities 1 | 33
Downturned corners of mouth 1 | 48
ESR raised 1 | 20
Edema 1 | 81
Exanthem 1 | 37
Exanthema 1 | 43
Familial Mediterranean fever 1 | 13
Familial cold autoinflammatory syndrome 1 | 10
Gastrointestinal Hemorrhage 1 | 52
Humoral hypercalcemia of malignancy 1 | 6
Hyperlipidemia 1 | 43
Hyperpigmented macules 1 | 42
Hypertriglyceridemia 1 | 17
Ichthyosis bullosa of Siemens 1 | 5
Increased chromosomal breakage 1 | 27
Intrahepatic cholestasis 1 | 20
Kidney Failure, Chronic 1 | 46
Liver Neoplasms, Experimental 1 | 59
Malignant neoplasm of skin 1 | 15
Mitral valve insufficiency 1 | 49
Muckle-Wells syndrome 1 | 12
Myocardial Infarction Prevention 1 | 7
POROKERATOSIS 7, MULTIPLE TYPES 1 | 1
Papule 1 | 43
Pharyngitis 1 | 17
Pityriasis versicolor 1 | 19
Primary Prevention of Coronary Heart Disease 1 | 4
Prinzmetal angina 1 | 6
Progressive cerebellar ataxia 1 | 13
Prominent metopic ridge 1 | 15
Pyoderma gangrenosum 1 | 9
Q fever 1 | 15
Recurrent aphthous ulcer 1 | 14
Skin Neoplasms 1 | 69
Tinea cruris 1 | 12
Waterhouse-Friderichsen syndrome 1 | 11

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Cardiovascular System 9 | 15,192
Nervous System 9 | 16,725

Target Family

Enzyme 9 | 4,145
Kinase 1 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Lathosterol oxidase SC5D Tbio Enzyme -1.42233 28.3 26
Sterol O-acyltransferase 2 SOAT2 Tchem Enzyme -1.60747 40.5 68
Phosphomevalonate kinase PMVK Tchem Enzyme -1.96385 92.3 144
Squalene monooxygenase SQLE Tchem Enzyme -1.89887 71.9 109
Farnesyl pyrophosphate synthase FDPS Tclin Enzyme -2.94323 876.8 272
Geranylgeranyl pyrophosphate synthase GGPS1 Tchem Enzyme -2.30083 190.0 301
Sterol O-acyltransferase 1 SOAT1 Tchem Enzyme -2.14394 138.3 129
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Mevalonate kinase MVK Tchem Kinase -2.25702 177.5 271