Development Level

Tbio 8 | 11,445
Tchem 6 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal cecum morphology 1 | 7
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged uterus 1 | 11
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased neutrophil cell numb... 1 | 46
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

glioblastoma 10 | 5,792
Carcinoma 9 | 11,493
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
ovarian cancer 8 | 8,520
malignant mesothelioma 7 | 3,232
osteosarcoma 7 | 7,950
adult high grade glioma 6 | 3,801
atypical teratoid / rhabdoid tumor 6 | 5,112
juvenile dermatomyositis 6 | 1,187
lung cancer 6 | 4,740
Astrocytoma, Pilocytic 5 | 3,081
Cancer 5 | 2,499
lung carcinoma 5 | 2,843
Rheumatoid arthritis 4 | 1,191
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Arthritis 3 | 290
Arthritis, Rheumatoid 3 | 174
Asthma 3 | 385
Cholestasis, Extrahepatic 3 | 25
Coronary artery disease 3 | 268
Hypersensitivity reaction type II disease 3 | 253
Liver Cirrhosis, Experimental 3 | 769
Meningitis 3 | 67
Peritonitis 3 | 43
Pneumonia 3 | 174
Prostatic Neoplasms 3 | 495
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
interstitial cystitis 3 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
Allergic hypersensitivity disease 2 | 126
Brain Injuries 2 | 65
Breast cancer 2 | 3,578
Cerebrovascular disease 2 | 238
Colorectal Neoplasms 2 | 243
Diarrhea 2 | 253
Duchenne muscular dystrophy 2 | 601
Eosinophilia 2 | 28
Gaucher disease type 3 2 | 67
Hypertension 2 | 396
Hypertensive disease 2 | 292
Hypohidrotic ectodermal dysplasia 2 | 15
Hypoxia-Ischemia, Brain 2 | 5
Immunologic Deficiency Syndromes 2 | 113
Inflammation 2 | 120
Inflammatory bowel disease 2 | 151
Influenza 2 | 142
Keratitis 2 | 62
Liver disease 2 | 237
Malaria 2 | 160
Mastitis 2 | 48
Melioidosis 2 | 17
Multiple Sclerosis 2 | 540
Neoplasm Invasiveness 2 | 161
Neoplasm Metastasis 2 | 168
Obesity 2 | 678
Osteoporosis 2 | 363
Perinatal necrotizing enterocolitis 2 | 21
Pick disease 2 | 1,894
Polycystic ovary syndrome 2 | 360
Reperfusion Injury 2 | 86
Salmonellosis 2 | 42
Schizophrenia 2 | 1,160
Sepsis 2 | 24
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
ependymoma 2 | 4,679
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
group 3 medulloblastoma 2 | 4,104
inflammatory breast cancer 2 | 286
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
periodontitis 2 | 293
ulcerative colitis 2 | 1,819
Acute cystitis 1 | 35
Adenocarcinoma Of Esophagus 1 | 14
Agenesis of teeth 1 | 21
Diffuse large B-cell lymphoma 1 | 39
Gastrointestinal stromal tumor 1 | 62
Hamman-Rich syndrome 1 | 34
Hemiparesis 1 | 34
Lung Injury 1 | 20
Pancreatic Neuroendocrine Tumor 1 | 45
Recurrent bacterial skin infections 1 | 8
Reduced number of teeth 1 | 21

Tissue

Blood and immune system 14 | 16,909
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678
Cardiovascular System 13 | 15,192
Respiratory system 13 | 16,393

Target Family

Non-IDG 8 | 12,091
Kinase 5 | 634
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lymphocyte antigen 96 LY96 Tchem Non-IDG -2.77678 541.2 369
Lipopolysaccharide-binding protein LBP Tbio Non-IDG -2.61682 357.2 225
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.90517 75.2 151
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Toll-interacting protein TOLLIP Tbio Non-IDG -1.87544 81.6 423
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.58807 348.8 804