Development Level

Tdark 40 | 6,593
Tbio 10 | 11,651
Tchem 7 | 1,388
Tclin 6 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96

Disease

osteosarcoma 24 | 7,950
interstitial cystitis 18 | 2,312
psoriasis 18 | 6,694
lung cancer 15 | 4,740
Cancer 14 | 2,499
tuberculosis 14 | 2,010
ulcerative colitis 14 | 1,819
Carcinoma 13 | 11,493
ovarian cancer 13 | 8,520
medulloblastoma, large-cell 11 | 6,241
primary Sjogren syndrome 11 | 735
lung adenocarcinoma 10 | 2,716
periodontitis 10 | 293
Autosomal recessive predisposition 9 | 1,442
invasive ductal carcinoma 9 | 2,951
pancreatic cancer 9 | 2,398
Agammaglobulinemia 8 | 34
Immunologic Deficiency Syndromes 8 | 113
Multiple myeloma 8 | 1,332
cutaneous lupus erythematosus 8 | 1,057
non-small cell lung cancer 8 | 2,890
Arthritis 7 | 290
Diarrhea 7 | 253
Failure to gain weight 7 | 365
Kidney cancer 7 | 2,613
Pediatric failure to thrive 7 | 365
chronic lymphosyte leukemia 7 | 204
glioblastoma 7 | 5,792
lung carcinoma 7 | 2,843
subependymal giant cell astrocytoma 7 | 2,287
Chronic otitis media 6 | 52
Conjunctivitis 6 | 53
Conjunctivitis, recurrent 6 | 37
Fatigue 6 | 182
Increased susceptibility to bacterial infections 6 | 42
Infantile onset 6 | 238
Prone to bacterial infection 6 | 42
Recurrent bacterial infection 6 | 42
Recurrent respiratory infections 6 | 141
ear infection chronic 6 | 52
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
nasopharyngeal carcinoma 6 | 1,058
AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE 5 | 8
Agammaglobulinemia, non-Bruton type 5 | 8
Astrocytoma, Pilocytic 5 | 3,081
Coughing 5 | 25
Diffuse large B-cell lymphoma 5 | 39
Exanthema 5 | 43
Fever 5 | 138
Infection of bone 5 | 19
Lymphoma, Large B-Cell, Diffuse 5 | 34
Osteomyelitis 5 | 42
Paranasal Sinus Diseases 5 | 34
Recurrent otitis media 5 | 42
Recurrent skin infections 5 | 21
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
Sinusitis 5 | 65
Waldenstrons macroglobulinemia 5 | 765
adult high grade glioma 5 | 3,801
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
cystic fibrosis and chronic rhinosinusitis 5 | 214
diabetes mellitus 5 | 1,728
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
juvenile dermatomyositis 5 | 1,187
non-small cell lung carcinoma 5 | 317
Breast cancer 4 | 3,578
Bronchiectasis 4 | 64
Cherubism 4 | 13
Infectious disease of lung 4 | 29
Lymphoproliferative syndrome 4 | 58
Multiple pulmonary infections 4 | 29
Recurrent pneumonia 4 | 29
Recurrent pulmonary infections 4 | 29
Stomach Neoplasms 4 | 300
atypical teratoid / rhabdoid tumor 4 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
primary pancreatic ductal adenocarcinoma 4 | 1,109
Adult T-Cell Lymphoma/Leukemia 3 | 30
Allergic hypersensitivity disease 3 | 126
Chronic obstructive pulmonary disease 3 | 184
Colorectal Neoplasms 3 | 243
Decreased antibody level in blood 3 | 35
Down syndrome 3 | 499
Frontal bossing 3 | 157
Hypogammaglobulinemia 3 | 35
Kidney disease 3 | 430
Leukemia-Lymphoma, Adult T-Cell 3 | 30
Liver Cirrhosis, Experimental 3 | 769
Multiple Sclerosis 3 | 540
Neutrophil count decreased 3 | 47
Renal Cell Carcinoma 3 | 214
acute myeloid leukemia 3 | 783
esophageal adenocarcinoma 3 | 737
oligodendroglioma 3 | 2,850
pancreatic carcinoma 3 | 562
sarcoidosis 3 | 370
spina bifida 3 | 1,074

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 52 | 12,091
Kinase 9 | 634
Enzyme 2 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
B-cell antigen receptor complex-associated protein beta chain CD79B Tbio Non-IDG -2.54957 343.5 681
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide DAPP1 Tbio Non-IDG -1.14626 21.0 307
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
B-lymphocyte antigen CD19 CD19 Tclin Non-IDG -3.54335 3206.2 2794
B-cell linker protein BLNK Tbio Non-IDG -2.82834 659.4 509
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD Tclin Kinase -2.85064 709.2 423