Development Level

Tchem 8 | 1,598
Tbio 3 | 11,445

IMPC Phenotype

abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499

Disease

Cancer 8 | 2,499
Carcinoma 8 | 11,493
glioblastoma 6 | 5,792
ovarian cancer 5 | 8,520
Brain Ischemia 3 | 110
Immunologic Deficiency Syndromes 3 | 113
Liver Cirrhosis, Experimental 3 | 769
astrocytoma 3 | 1,146
ependymoma 3 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
Agammaglobulinemia 2 | 34
Arthritis 2 | 290
Astrocytoma, Pilocytic 2 | 3,081
Autoimmune lymphoproliferative syndrome type 2B 2 | 9
Autosomal recessive predisposition 2 | 1,442
Breast Neoplasms 2 | 445
Cell Transformation, Neoplastic 2 | 97
Colitis, Ulcerative 2 | 59
Colonic Neoplasms 2 | 142
Crohn's disease 2 | 321
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Ectodermal dysplasia, hypohidrotic, with immune deficiency 2 | 2
Frontal bossing 2 | 157
Heat Stroke 2 | 13
Hypertension 2 | 396
Hypodontia 2 | 81
Hypohidrotic ectodermal dysplasia with immunodeficiency 2 | 2
Infantile onset 2 | 238
Inflammatory bowel disease 2 | 151
Kidney Failure, Chronic 2 | 46
Kidney cancer 2 | 2,613
Lack of sweat glands 2 | 2
Mammary Neoplasms 2 | 425
Mantle cell lymphoma 2 | 23
Multiple myeloma 2 | 1,332
Neoplastic Cell Transformation 2 | 89
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Small head 2 | 374
Sparse hair 2 | 59
Thin, sparse hair 2 | 59
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
group 4 medulloblastoma 2 | 1,855
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
osteosarcoma 2 | 7,950
posterior fossa group A ependymoma 2 | 468
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) 1 | 1
Abnormal hand morphology 1 | 2
Abnormal pigmentation 1 | 25
Anemia, Hemolytic 1 | 55
Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 1 | 1
Asymmetric growth 1 | 5
Atrophic, patchy alopecia 1 | 1
Atypical Mycobacteriosis, Familial, X-Linked 1 1 | 1
Barrett Esophagus 1 | 16
Brain cancer 1 | 30
Bronchiectasis 1 | 64
Calcinosis 1 | 70
Carcinoma of thyroid 1 | 17
Cholestasis, Extrahepatic 1 | 25
Diabetic Nephropathy 1 | 34
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema 1 | 1
Hearing abnormality 1 | 12
Hyperglycemia 1 | 137
Hypoplastic fingernails 1 | 11
INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) 1 | 1
Immunodeficiency without anhidrotic ectodermal dysplasia 1 | 1
Impaired memory B-cell generation 1 | 3
Incontinentia Pigmenti 1 | 1
Incontinentia pigmenti syndrome 1 | 1
Increased IgM levels 1 | 16
Increased susceptibility to bacterial infections 1 | 42
Invasive pneumococcal disease, recurrent isolated, 2 1 | 1
Irregular hyperpigmentation 1 | 33
Onset of lymphedema around puberty 1 | 21
Oral cleft 1 | 18
Ovarian Cysts 1 | 41
Peg shaped front tooth 1 | 6
Peg-shaped incisors 1 | 6
Pointed front tooth 1 | 6
Pointed incisor 1 | 6
Prone to bacterial infection 1 | 42
Recurrent bacterial infection 1 | 42
Recurrent bronchitis 1 | 23
Recurrent mycobacterium avium complex infections 1 | 2
Warts 1 | 10
X- linked recessive 1 | 110
hypopigmented skin patch 1 | 59
ulnar-mammary syndrome 1 | 8

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Kinase 6 | 634
Non-IDG 3 | 12,091
Transcription Factor 2 | 1,400

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 11 | 11
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B inhibitor epsilon NFKBIE Tbio Non-IDG -1.39025 20.6 313
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.22748 161.7 603
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Receptor-interacting serine/threonine-protein kinase 2 RIPK2 Tchem Kinase -2.03990 107.3 474
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34987 1979.8 1300
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.36360 203.6 1101
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762