Development Level

Tchem 118 | 1,598
Tclin 36 | 613
Tbio 18 | 11,445
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 11 | 125
RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 10 | 499
abnormal bone structure 9 | 187
embryonic lethality prior to t... 8 | 278
abnormal embryo size 7 | 220
embryonic lethality prior to o... 7 | 239
decreased body weight 4 | 161
decreased vertical activity 4 | 208
enlarged heart 4 | 210
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
decreased bone mineral content 3 | 151
decreased circulating LDL chol... 3 | 38
enlarged spleen 3 | 41
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal skin morphology 2 | 50
anophthalmia 2 | 33
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating iron lev... 2 | 30
increased mean platelet volume 2 | 45
male infertility 2 | 123
microphthalmia 2 | 26
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytosis 2 | 27
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged thymus 1 | 5
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
limb grasping 1 | 41
shortened RR interval 1 | 17
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 148 | 11,493
osteosarcoma 107 | 7,950
ovarian cancer 104 | 8,520
Cancer 92 | 2,499
glioblastoma 91 | 5,792
medulloblastoma, large-cell 88 | 6,241
psoriasis 78 | 6,694
atypical teratoid / rhabdoid tumor 77 | 5,112
lung cancer 65 | 4,740
ependymoma 64 | 4,679
adult high grade glioma 62 | 3,801
Kidney cancer 54 | 2,613
malignant mesothelioma 54 | 3,232
group 3 medulloblastoma 52 | 4,104
Astrocytoma, Pilocytic 51 | 3,081
Breast cancer 49 | 3,578
oligodendroglioma 46 | 2,850
primitive neuroectodermal tumor 45 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
non-small cell lung cancer 44 | 2,890
astrocytic glioma 38 | 2,597
lung carcinoma 36 | 2,843
tuberculosis 36 | 2,010
invasive ductal carcinoma 35 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
subependymal giant cell astrocytoma 32 | 2,287
Schizophrenia 30 | 1,160
lung adenocarcinoma 29 | 2,716
group 4 medulloblastoma 28 | 1,855
interstitial cystitis 28 | 2,312
ulcerative colitis 28 | 1,819
Pick disease 27 | 1,894
pancreatic cancer 27 | 2,398
adrenocortical carcinoma 26 | 1,428
Autosomal recessive predisposition 25 | 1,442
Renal Cell Carcinoma 24 | 214
diabetes mellitus 24 | 1,728
Rheumatoid arthritis 23 | 1,191
cystic fibrosis 23 | 1,696
astrocytoma 22 | 1,146
breast carcinoma 22 | 1,638
pituitary cancer 22 | 1,972
colon cancer 20 | 1,478
Breast Neoplasms 19 | 445
Mammary Neoplasms 19 | 425
Bipolar Disorder 18 | 666
Depressive disorder 18 | 409
Intellectual disability 18 | 1,016
Short stature 18 | 531
ductal carcinoma in situ 18 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Alzheimer's disease 17 | 658
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Prostatic Neoplasms 16 | 495
Stomach Neoplasms 16 | 300
Vascular disease 16 | 319
Epilepsy 15 | 792
Hypertensive disease 15 | 292
Lung Neoplasms 15 | 232
Melanoma 15 | 711
Obesity 15 | 678
Orbital separation excessive 15 | 244
Seizures 15 | 596
spina bifida 15 | 1,074
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Hamman-Rich syndrome 14 | 34
Mental and motor retardation 14 | 608
Parkinson's disease 14 | 392
acute myeloid leukemia 14 | 783
Acquired scoliosis 13 | 281
Blastic phase chronic myeloid leukemia 13 | 58
Byzanthine arch palate 13 | 194
Chronic Myelocytic Leukemia Accelerated Phase 13 | 59
Curvature of spine 13 | 282
Waldenstrons macroglobulinemia 13 | 765
acute quadriplegic myopathy 13 | 1,158
juvenile dermatomyositis 13 | 1,187
primary Sjogren syndrome 13 | 735
primary pancreatic ductal adenocarcinoma 13 | 1,109
Cardiomegaly 12 | 116
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Gastrointestinal stromal tumor 12 | 62
Heart disease 12 | 306
Hyperalgesia 12 | 83
Hypertension 12 | 396
Major Depressive Disorder 12 | 301
Mental Depression 12 | 333
Multiple myeloma 12 | 1,332
Skin cancer 12 | 469
cutaneous lupus erythematosus 12 | 1,057
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275

Tissue

Endocrine System 173 | 18,159
Digestive Tract 171 | 17,369
Male tissues 171 | 17,142
Skin and soft tissues 171 | 17,230
Female tissues 170 | 17,400
Blood and immune system 169 | 16,909
Cardiovascular System 169 | 15,192
Liver and Pancreas 169 | 16,750
Respiratory system 168 | 16,393
Urinary Tract 168 | 16,678
Nervous System 167 | 16,725

Target Family

Kinase 160 | 634
Enzyme 8 | 4,145
Non-IDG 5 | 12,091

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Rhodopsin kinase GRK7 Tchem Kinase -1.83396 45.0 180
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199