Development Level

Tbio 7 | 11,651
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal forelimb morphology 1 | 2
abnormal heart morphology 1 | 162
abnormal response to tactile s... 1 | 17
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
syndactyly 1 | 23

Disease

Carcinoma 7 | 11,493
psoriasis 6 | 6,694
atypical teratoid / rhabdoid tumor 5 | 5,112
breast carcinoma 5 | 1,638
ependymoma 5 | 4,679
invasive ductal carcinoma 5 | 2,951
Breast cancer 4 | 3,578
glioblastoma 4 | 5,792
interstitial cystitis 4 | 2,312
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
ovarian cancer 4 | 8,520
Bipolar Disorder 3 | 666
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
non-small cell lung cancer 3 | 2,890
osteosarcoma 3 | 7,950
primitive neuroectodermal tumor 3 | 3,035
Acquired metabolic disease 2 | 336
Astrocytoma, Pilocytic 2 | 3,081
Breast Neoplasms 2 | 445
Colonic Neoplasms 2 | 142
Kidney cancer 2 | 2,613
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma, large-cell 2 | 6,241
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
sarcoidosis 2 | 370
urothelial carcinoma 2 | 318
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Alopecia 1 | 115
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Animal Mammary Neoplasms 1 | 136
Arthritis, Juvenile 1 | 126
Arthritis, Rheumatoid 1 | 174
Atopic dermatitis 1 | 952
Cancer 1 | 2,499
Cardiovascular system disease 1 | 246
Colorectal Neoplasms 1 | 243
Coronary Disease 1 | 25
Crohn Disease 1 | 45
Depressive disorder 1 | 409
Diabetes Mellitus, Non-Insulin-Dependent 1 | 145
Diabetes Mellitus, Type 2 1 | 142
Disease Models, Animal 1 | 155
Duchenne muscular dystrophy 1 | 601
Hyperplasia 1 | 27
Juvenile arthritis 1 | 126
Leukemia, Lymphocytic, Chronic, B-Cell 1 | 34
Lupus Erythematosus, Systemic 1 | 67
Mammary Neoplasms 1 | 425
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Mental Depression 1 | 333
Metabolic syndrome X 1 | 52
Multiple Sclerosis 1 | 540
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 161
Neoplasm Metastasis 1 | 168
Neurodevelopmental Disorders 1 | 70
Polycystic ovary syndrome 1 | 360
Schizoaffective Disorder 1 | 55
Schizophrenia 1 | 1,160
Systemic lupus erythematosus 1 | 194
Type 2 diabetes mellitus 1 | 272
Vascular disease 1 | 319
active Crohn's disease 1 | 922
acute myeloid leukemia 1 | 783
acute quadriplegic myopathy 1 | 1,158
adrenocortical carcinoma 1 | 1,428
aldosterone-producing adenoma 1 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
chronic lymphosyte leukemia 1 | 204
dermatomyositis 1 | 966
diabetes mellitus 1 | 1,728
gastric carcinoma 1 | 807
inflammatory breast cancer 1 | 286
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
juvenile dermatomyositis 1 | 1,187
pancreatic carcinoma 1 | 562
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
primary pancreatic ductal adenocarcinoma 1 | 1,109
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Non-IDG 4 | 12,091
Transcription Factor 4 | 1,400

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.20549 17.1 109
Transcription factor 7 TCF7 Tbio Transcription Factor -1.74770 44.8 325
Transducin-like enhancer protein 3 TLE3 Tbio Non-IDG -1.49813 35.4 67
Transducin-like enhancer protein 2 TLE2 Tbio Non-IDG -1.13307 13.4 141
Transducin-like enhancer protein 1 TLE1 Tbio Non-IDG -2.01828 106.9 376
Transducin-like enhancer protein 4 TLE4 Tbio Non-IDG -1.51608 30.3 197
Transcription factor 7-like 2 TCF7L2 Tbio Transcription Factor -2.63620 474.2 327