Development Level

Tbio 19 | 11,445
Tclin 19 | 613
Tchem 2 | 1,598

IMPC Phenotype

improved glucose tolerance 3 | 79
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased blood urea nitrogen ... 2 | 51
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased circulating calcium ... 2 | 34
increased circulating total pr... 2 | 28
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
preweaning lethality, complete... 2 | 979
abnormal brain morphology 1 | 13
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged liver 1 | 2
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
small seminal vesicle 1 | 10
thrombocytopenia 1 | 56
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 34 | 11,493
lung cancer 28 | 4,740
osteosarcoma 28 | 7,950
psoriasis 25 | 6,694
lung carcinoma 24 | 2,843
ovarian cancer 23 | 8,520
glioblastoma 22 | 5,792
Cancer 19 | 2,499
interstitial cystitis 18 | 2,312
medulloblastoma, large-cell 17 | 6,241
malignant mesothelioma 16 | 3,232
ulcerative colitis 16 | 1,819
Astrocytoma, Pilocytic 15 | 3,081
lung adenocarcinoma 15 | 2,716
non-small cell lung cancer 15 | 2,890
tuberculosis 14 | 2,010
Rheumatoid arthritis 13 | 1,191
pancreatic cancer 13 | 2,398
Asthma 12 | 385
Autosomal recessive predisposition 12 | 1,442
cutaneous lupus erythematosus 12 | 1,057
Breast cancer 11 | 3,578
adult high grade glioma 11 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pituitary cancer 11 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
Schizophrenia 9 | 1,160
atypical teratoid / rhabdoid tumor 9 | 5,112
group 3 medulloblastoma 9 | 4,104
Atopic dermatitis 8 | 952
Pneumonia 8 | 174
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
ependymoma 7 | 4,679
gastric carcinoma 7 | 807
primary Sjogren syndrome 7 | 735
subependymal giant cell astrocytoma 7 | 2,287
Hypersensitivity 6 | 63
Liver Cirrhosis, Experimental 6 | 769
Pruritus 6 | 58
acute quadriplegic myopathy 6 | 1,158
diabetes mellitus 6 | 1,728
mucosa-associated lymphoid tissue lymphoma 6 | 484
non-small cell lung carcinoma 6 | 317
Brain Injuries 5 | 65
Endometriosis 5 | 540
Hepatomegaly 5 | 285
Inflammatory bowel disease 5 | 151
Kidney cancer 5 | 2,613
Melanoma 5 | 711
Multiple Sclerosis 5 | 540
Relapsing remitting multiple sclerosis 5 | 14
active Crohn's disease 5 | 922
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
juvenile dermatomyositis 5 | 1,187
oligodendroglioma 5 | 2,850
pancreatic carcinoma 5 | 562
Ankylosing spondylitis 4 | 140
Arthralgia 4 | 90
Arthritis 4 | 290
Arthritis, Rheumatoid 4 | 174
Colitis, Ulcerative 4 | 59
Gaucher disease type 1 4 | 180
Hepatitis B 4 | 108
Hypersensitivity reaction type II disease 4 | 253
Immunologic Deficiency Syndromes 4 | 113
Juvenile rheumatoid arthritis 4 | 111
Liver diseases 4 | 87
Myocardial Ischemia 4 | 169
Pick disease 4 | 1,894
Splenomegaly 4 | 190
Waldenstrons macroglobulinemia 4 | 765
active ulcerative colitis 4 | 764
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
medulloblastoma 4 | 720
pediatric high grade glioma 4 | 1,064
periodontitis 4 | 293
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
Brain Ischemia 3 | 110
Chronic obstructive pulmonary disease 3 | 184
Down syndrome 3 | 499
Duchenne muscular dystrophy 3 | 601
Lymphadenitis 3 | 15
Mycobacterium Infections, Nontuberculous 3 | 5
Osteomyelitis 3 | 42
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
chronic lymphosyte leukemia 3 | 204
hepatocellular carcinoma 3 | 547
nasopharyngeal carcinoma 3 | 1,058

Tissue

Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Non-IDG 38 | 12,091
GPCR 2 | 408

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.87313 723.9 643
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Granulocyte colony-stimulating factor receptor CSF3R Tclin Non-IDG -2.22680 182.3 442
Erythropoietin receptor EPOR Tclin Non-IDG -2.83058 631.6 588
Ciliary neurotrophic factor receptor subunit alpha CNTFR Tbio Non-IDG -1.63139 35.8 217
Interleukin-12 receptor subunit beta-1 IL12RB1 Tbio Non-IDG -2.33532 220.9 273
Oncostatin-M-specific receptor subunit beta OSMR Tbio Non-IDG -2.26877 178.8 258
Interleukin-18 receptor 1 IL18R1 Tbio Non-IDG -1.49759 28.8 503