Development Level

Tchem 113 | 1,388
Tclin 40 | 612
Tbio 29 | 11,651
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 11 | 125
RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 11 | 499
abnormal bone structure 9 | 187
embryonic lethality prior to t... 8 | 278
abnormal embryo size 7 | 220
embryonic lethality prior to o... 7 | 239
decreased body weight 5 | 161
decreased vertical activity 4 | 208
enlarged heart 4 | 210
increased total body fat amoun... 4 | 134
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
decreased bone mineral content 3 | 151
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased fasted circulating g... 3 | 65
enlarged spleen 3 | 41
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal bone mineralization 2 | 38
abnormal digit morphology 2 | 10
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal skin morphology 2 | 50
anophthalmia 2 | 33
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased circulating creatini... 2 | 39
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating iron lev... 2 | 30
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
male infertility 2 | 123
microphthalmia 2 | 26
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytosis 2 | 27
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
limb grasping 1 | 41
shortened RR interval 1 | 17
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 156 | 11,493
osteosarcoma 113 | 7,950
ovarian cancer 110 | 8,520
Cancer 102 | 2,499
glioblastoma 96 | 5,792
medulloblastoma, large-cell 93 | 6,241
psoriasis 84 | 6,694
atypical teratoid / rhabdoid tumor 81 | 5,112
lung cancer 72 | 4,740
ependymoma 67 | 4,679
adult high grade glioma 64 | 3,801
malignant mesothelioma 59 | 3,232
Kidney cancer 57 | 2,613
Breast cancer 54 | 3,578
group 3 medulloblastoma 54 | 4,104
Astrocytoma, Pilocytic 52 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
oligodendroglioma 47 | 2,850
primitive neuroectodermal tumor 47 | 3,035
non-small cell lung cancer 46 | 2,890
invasive ductal carcinoma 40 | 2,951
tuberculosis 39 | 2,010
astrocytic glioma 38 | 2,597
lung carcinoma 38 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
Schizophrenia 34 | 1,160
subependymal giant cell astrocytoma 34 | 2,287
interstitial cystitis 33 | 2,312
lung adenocarcinoma 32 | 2,716
ulcerative colitis 31 | 1,819
pancreatic cancer 30 | 2,398
group 4 medulloblastoma 29 | 1,855
Pick disease 28 | 1,894
Autosomal recessive predisposition 27 | 1,442
cystic fibrosis 27 | 1,696
adrenocortical carcinoma 26 | 1,428
diabetes mellitus 26 | 1,728
Renal Cell Carcinoma 25 | 214
Rheumatoid arthritis 25 | 1,191
breast carcinoma 25 | 1,638
pituitary cancer 25 | 1,972
Breast Neoplasms 22 | 445
Mammary Neoplasms 22 | 425
astrocytoma 22 | 1,146
colon cancer 22 | 1,478
ductal carcinoma in situ 22 | 1,745
Bipolar Disorder 20 | 666
Depressive disorder 20 | 409
Intellectual disability 19 | 1,016
Prostatic Neoplasms 19 | 495
Short stature 18 | 531
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Alzheimer's disease 17 | 658
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Stomach Neoplasms 17 | 300
Vascular disease 17 | 319
Epilepsy 16 | 792
Lung Neoplasms 16 | 232
Melanoma 16 | 711
Obesity 16 | 678
Orbital separation excessive 16 | 244
Seizures 16 | 596
spina bifida 16 | 1,074
Cognitive delay 15 | 608
Global developmental delay 15 | 608
Hypertensive disease 15 | 292
Mental and motor retardation 15 | 608
Parkinson's disease 15 | 392
acute myeloid leukemia 15 | 783
juvenile dermatomyositis 15 | 1,187
primary Sjogren syndrome 15 | 735
Acquired scoliosis 14 | 281
Byzanthine arch palate 14 | 194
Curvature of spine 14 | 282
Hamman-Rich syndrome 14 | 34
Waldenstrons macroglobulinemia 14 | 765
cutaneous lupus erythematosus 14 | 1,057
primary pancreatic ductal adenocarcinoma 14 | 1,109
Blastic phase chronic myeloid leukemia 13 | 58
Chronic Myelocytic Leukemia Accelerated Phase 13 | 59
Concave bridge of nose 13 | 195
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
Heart disease 13 | 306
Hypertension 13 | 396
Hypoplastic mandible condyle 13 | 275
Major Depressive Disorder 13 | 301
Mandibular hypoplasia 13 | 275
Mental Depression 13 | 333
Micrognathism 13 | 275
acute quadriplegic myopathy 13 | 1,158
Arthritis 12 | 290
Failure to gain weight 12 | 365
Pediatric failure to thrive 12 | 365
Skin cancer 12 | 469

Tissue

Endocrine System 183 | 18,159
Digestive Tract 181 | 17,369
Male tissues 181 | 17,142
Skin and soft tissues 181 | 17,230
Female tissues 180 | 17,400
Blood and immune system 179 | 16,909
Cardiovascular System 179 | 15,192
Liver and Pancreas 179 | 16,750
Respiratory system 178 | 16,393
Urinary Tract 178 | 16,678
Nervous System 177 | 16,725

Target Family

Kinase 164 | 634
Enzyme 10 | 4,145
Non-IDG 9 | 12,091

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603