Development Level

Tbio 17 | 11,445
Tchem 4 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
microphthalmia 2 | 26
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal limb morphology 1 | 13
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
decreased body length 1 | 101
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased startle reflex 1 | 75
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating insulin ... 1 | 3
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
polydactyly 1 | 7
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
protruding tongue 1 | 3
small superior vagus ganglion 1 | 74

Disease

Carcinoma 20 | 11,493
osteosarcoma 16 | 7,950
psoriasis 16 | 6,694
ovarian cancer 15 | 8,520
atypical teratoid / rhabdoid tumor 14 | 5,112
Cancer 13 | 2,499
ependymoma 11 | 4,679
glioblastoma 10 | 5,792
Breast cancer 9 | 3,578
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
Kidney cancer 8 | 2,613
medulloblastoma, large-cell 8 | 6,241
interstitial cystitis 7 | 2,312
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
malignant mesothelioma 6 | 3,232
pituitary cancer 6 | 1,972
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
non-small cell lung cancer 5 | 2,890
Astrocytoma, Pilocytic 4 | 3,081
Colonic Neoplasms 4 | 142
Familial adenomatous polyposis 4 | 32
Liver cancer 4 | 604
Osteoporosis 4 | 363
Pick disease 4 | 1,894
Renal Cell Carcinoma 4 | 214
Robinow syndrome 4 | 11
acute myeloid leukemia 4 | 783
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
medulloblastoma 4 | 720
osteoporosis-pseudoglioma syndrome 4 | 9
spina bifida 4 | 1,074
tuberculosis 4 | 2,010
Bipolar Disorder 3 | 666
Carcinoma of colon 3 | 32
Carcinoma, Hepatocellular 3 | 228
Colorectal Neoplasms 3 | 243
Endometrial cancer 3 | 311
Exudative vitreoretinopathy 3 | 15
Hereditary nonpolyposis colorectal carcinoma 3 | 18
Hypoplastic mandible condyle 3 | 275
Increased gastric cancer 3 | 21
Increased hepatocellular carcinoma risk 3 | 27
Increased incidence of hepatocellular carcinoma 3 | 27
Infantile onset 3 | 238
Intellectual disability 3 | 1,016
Leiomyosarcoma of uterus 3 | 13
Liver carcinoma 3 | 240
Long philtrum 3 | 137
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Micronodular cirrhosis 3 | 12
Orbital separation excessive 3 | 244
Prostatic Neoplasms 3 | 495
Somatic mutation 3 | 61
Stomach Neoplasms 3 | 300
Subacute progressive viral hepatitis 3 | 9
Transitional cell carcinoma of bladder 3 | 17
Vascular disease 3 | 319
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
Abdominal Pain 2 | 98
Abnormality of retinal pigmentation 2 | 111
Big calvaria 2 | 147
Blind Vision 2 | 111
Blindness, Legal 2 | 110
Craniofacial Abnormalities 2 | 151
Frequent fractures 2 | 53
Frontal bossing 2 | 157
Headache 2 | 37
High forehead 2 | 102
Increased fracture rate 2 | 53
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Large intestine cancer 2 | 126
Malabsorption 2 | 82
Osteoarthritis 2 | 184
Retinal Detachment 2 | 51
Retinal pigment epithelial abnormality 2 | 111
Slow progression 2 | 89
Tall forehead 2 | 102
Varying degree of multiple fractures 2 | 53

Tissue

Blood and immune system 22 | 16,909
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Skin and soft tissues 22 | 17,230
Cardiovascular System 21 | 15,192
Liver and Pancreas 21 | 16,750
Respiratory system 21 | 16,393
Urinary Tract 21 | 16,678

Target Family

Non-IDG 12 | 12,091
GPCR 10 | 408
Kinase 2 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative segment polarity protein dishevelled homolog DVL1P1 DVL1P1 Tdark Non-IDG -2.11561 188.4 0
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Frizzled-3 FZD3 Tbio GPCR -1.76528 56.4 314
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.90646 66.5 508
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307