Development Level

Tbio 5 | 11,445
Tchem 5 | 1,598
Tclin 3 | 613

IMPC Phenotype

decreased circulating LDL chol... 2 | 38
increased circulating LDL chol... 2 | 13
increased mean corpuscular hem... 2 | 96
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating triglyce... 1 | 79
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
increased cardiac stroke volum... 1 | 1
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
thrombocytosis 1 | 27

Disease

Carcinoma 11 | 11,493
ovarian cancer 11 | 8,520
Cancer 10 | 2,499
Epilepsy 7 | 792
osteosarcoma 7 | 7,950
Intellectual disability 6 | 1,016
Seizures 6 | 596
medulloblastoma, large-cell 6 | 6,241
subependymal giant cell astrocytoma 6 | 2,287
Breast cancer 5 | 3,578
Dull intelligence 5 | 645
Kidney cancer 5 | 2,613
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Renal Cell Carcinoma 5 | 214
Schizophrenia 5 | 1,160
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
psoriasis 5 | 6,694
Breast Neoplasms 4 | 445
Carcinoma, Squamous Cell 4 | 110
Cognitive delay 4 | 608
Diffuse large B-cell lymphoma 4 | 39
Fibrous skin tumor of tuberous sclerosis 4 | 18
Global developmental delay 4 | 608
Hypothyroidism 4 | 122
Lymphoma, Large B-Cell, Diffuse 4 | 34
Mammary Neoplasms 4 | 425
Mental and motor retardation 4 | 608
Multiple, subcutaneous nodules 4 | 53
Papule 4 | 43
Sebaceous adenoma 4 | 26
Skin tag 4 | 14
Squamous cell carcinoma 4 | 129
Subcutaneous nodule 4 | 53
Tuberous sclerosis 4 | 19
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
lung cancer 4 | 4,740
Abdominal Pain 3 | 98
Adult onset 3 | 82
Angiomyolipoma 3 | 18
Attention deficit hyperactivity disorder 3 | 278
Autistic Disorder 3 | 364
Big calvaria 3 | 147
Cafe au lait spots, multiple 3 | 17
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Renal Cell 3 | 124
Concave bridge of nose 3 | 195
Congenital hemihypertrophy 3 | 6
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Endometrial cancer 3 | 311
Focal cortical dysplasia of Taylor 3 | 3
Gynecomastia 3 | 64
Impaired cognition 3 | 96
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Isolated cases 3 | 72
Kidney angiomyolipoma 3 | 8
Liver carcinoma 3 | 240
Lymphadenopathy 3 | 62
Lymphangioleiomyomatosis 3 | 16
Malformations of Cortical Development 3 | 13
Mental impairment 3 | 95
Microstomia 3 | 78
Mouth Neoplasms 3 | 55
Obesity 3 | 678
Orbital separation excessive 3 | 244
Ovarian Neoplasms 3 | 102
Port-Wine Stain 3 | 8
Prostatic Neoplasms 3 | 495
Proteus syndrome 3 | 6
Splenomegaly 3 | 190
diabetes mellitus 3 | 1,728
follicular lymphoma 3 | 20
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Carcinoma, squamous cell of head and neck 2 | 31
Cardiac rhabdomyoma 2 | 5
Cerebral calcification 2 | 43
Colon diverticulum anatomic structure 2 | 15
Coughing 2 | 25
Diverticular disease of colon 2 | 15
Hematuria 2 | 36
Hyperglycemia 2 | 137
Hyperkyphosis 2 | 111
Infiltrate of lung 2 | 17
Kyphosis deformity of spine 2 | 114
Neurofibromatosis 2 | 40
Ovarian Cysts 2 | 41
Papilloma 2 | 44
Precancerous Conditions 2 | 80

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Kinase 8 | 634
Non-IDG 5 | 12,091

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Target of rapamycin complex 2 subunit MAPKAP1 MAPKAP1 Tbio Non-IDG -2.01676 101.3 244
Target of rapamycin complex subunit LST8 MLST8 Tbio Non-IDG -2.64631 429.3 360
Tuberin TSC2 Tbio Non-IDG -2.99381 1000.6 1632
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.12025 204.9 608
Hamartin TSC1 Tbio Non-IDG -2.25451 173.9 1622
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
RAC-beta serine/threonine-protein kinase AKT2 Tchem Kinase -2.60567 332.5 1173
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.89596 7790.5 1195
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PIK3CB Tchem Kinase -2.29043 197.8 384