Development Level

Tchem 5 | 1,598
Tbio 2 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal lens morphology 1 | 81
cataract 1 | 92
increased circulating glucose ... 1 | 24
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 8 | 2,499
Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
Abnormal dermatoglyphic pattern 7 | 24
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Cardiac Arrhythmia 7 | 103
Cardiac conduction abnormalities 7 | 78
Conduction disorder of the heart 7 | 79
Congenital pectus carinatum 7 | 52
Cryptorchidism 7 | 296
Curly hair (finding) 7 | 14
Delayed bone age 7 | 136
Downward slant of palpebral fissure 7 | 158
EKG abnormalities 7 | 78
Electrocardiogram abnormal 7 | 81
Electrocardiogram change 7 | 78
Excess nuchal skin 7 | 30
Full lower lip 7 | 64
Hypoplastic mandible condyle 7 | 275
Joint hyperflexibility 7 | 78
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Muscle hypotonia 7 | 571
Neck webbing 7 | 35
Noonan syndrome 7 | 34
Orbital separation excessive 7 | 244
Prominent lower lip 7 | 64
Short stature 7 | 531
Strabismus 7 | 270
Abnormal hair quantity 6 | 16
Abnormal platelet function 6 | 12
Abnormality of pulmonary valve 6 | 23
Abnormality of the spleen 6 | 13
Acquired scoliosis 6 | 281
Aplasia/Hypoplasia of the abdominal wall musculature 6 | 17
Bleeding tendency 6 | 37
Blood Coagulation Disorders 6 | 42
Coagulation abnormalities 6 | 27
Coarse hair 6 | 31
Curvature of spine 6 | 282
Decreased projection of midface 6 | 105
Dysarthria 6 | 192
Enlarged thorax 6 | 18
Exophthalmos 6 | 112
Feeding difficulties in infancy 6 | 175
Hemorrhagic Disorders 6 | 30
Hepatomegaly 6 | 285
High forehead 6 | 102
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Hypotrophic midface 6 | 105
Kidney cancer 6 | 2,613
Low posterior hairline 6 | 52
Low-set, posteriorly rotated ears 6 | 110
Lymphangioma, Cystic 6 | 21
Midface retrusion 6 | 105
Muscle Weakness 6 | 170
Pectus excavatum 6 | 100
Prominent eyes 6 | 96
Prominent globes 6 | 96
Protruding eyes 6 | 96
Pulmonary Stenosis 6 | 45
Pulmonary artery stenosis 6 | 22
Rough hair texture 6 | 31
Short neck 6 | 140
Small midface 6 | 105
Tall forehead 6 | 102
Thickened helices 6 | 15
Triangular face 6 | 58
Wide spaced nipples 6 | 46
glioblastoma 6 | 5,792
lung cancer 6 | 4,740
osteosarcoma 6 | 7,950
Aortic coarctation 5 | 30
Breast cancer 5 | 3,578
Concave bridge of nose 5 | 195
Congenital Epicanthus 5 | 177
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Low set ears 5 | 181
Melanocytic nevus 5 | 43
Noncancerous mole 5 | 28
atypical teratoid / rhabdoid tumor 5 | 5,112
Adenocarcinoma of lung 4 | 142
Big calvaria 4 | 147
Electroencephalogram abnormal 4 | 101
Epilepsy 4 | 792
Frontal bossing 4 | 157
Ichthyoses 4 | 41
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Liver neoplasms 4 | 130
Lung Neoplasms 4 | 232
Melanoma 4 | 711
Seizures 4 | 596
Ventricular Septal Defects 4 | 119
astrocytic glioma 4 | 2,597
psoriasis 4 | 6,694

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Enzyme 3 | 4,145
Kinase 3 | 634
Non-IDG 3 | 12,091

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 236 | 236
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
Serine/threonine-protein kinase A-Raf ARAF Tchem Kinase -2.46615 277.6 465
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.33582 220.9 1431
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.11577 1210.8 2254