Development Level

Tbio 9 | 11,445
Tchem 4 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased body weight 2 | 161
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
thick ventricular wall 1 | 7

Disease

Carcinoma 15 | 11,493
Cancer 13 | 2,499
osteosarcoma 13 | 7,950
ovarian cancer 13 | 8,520
glioblastoma 10 | 5,792
lung cancer 8 | 4,740
medulloblastoma, large-cell 8 | 6,241
psoriasis 8 | 6,694
ependymoma 7 | 4,679
Astrocytoma, Pilocytic 6 | 3,081
Breast cancer 6 | 3,578
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Short stature 6 | 531
atypical teratoid / rhabdoid tumor 6 | 5,112
juvenile dermatomyositis 6 | 1,187
pancreatic cancer 6 | 2,398
Blepharoptosis 5 | 231
Congenital Epicanthus 5 | 177
Cryptorchidism 5 | 296
Downward slant of palpebral fissure 5 | 158
Dull intelligence 5 | 645
Feeding difficulties in infancy 5 | 175
High forehead 5 | 102
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Low-set, posteriorly rotated ears 5 | 110
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple myeloma 5 | 1,332
Orbital separation excessive 5 | 244
Poor school performance 5 | 645
Premature Birth 5 | 77
Premature birth of newborn 5 | 67
Short neck 5 | 140
Strabismus 5 | 270
Tall forehead 5 | 102
astrocytic glioma 5 | 2,597
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Absence of eyebrows 4 | 31
Acquired scoliosis 4 | 281
Anteverted nostril 4 | 191
Aplasia/Hypoplasia of the eyebrow 4 | 31
Big calvaria 4 | 147
Breast Neoplasms 4 | 445
Byzanthine arch palate 4 | 194
Cardiomyopathy 4 | 116
Concave bridge of nose 4 | 195
Curvature of spine 4 | 282
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Dry skin 4 | 75
Frontal bossing 4 | 157
Hypertrophic Cardiomyopathy 4 | 117
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Kidney Neoplasm 4 | 29
Kidney Neoplasms 4 | 37
Kidney cancer 4 | 2,613
LEOPARD syndrome 4 | 20
Long philtrum 4 | 137
Low posterior hairline 4 | 52
Lung Neoplasms 4 | 232
Malignant Melanoma with BRAF V600E Mutation 4 | 4
Mammary Neoplasms 4 | 425
Metastatic malignant melanoma 4 | 9
Multiple lentigines 4 | 10
Muscle hypotonia 4 | 571
Neck webbing 4 | 35
Noonan syndrome 4 | 34
Pectus excavatum 4 | 100
Prostatic Neoplasms 4 | 495
Pulmonary Stenosis 4 | 45
Senile lentigo 4 | 10
Short nose 4 | 132
Skin hyperelastic 4 | 32
Small nose 4 | 132
Sparse or absent eyebrows 4 | 31
Sparse/absent eyebrows 4 | 31
Thickened helices 4 | 15
Xerosis 4 | 75
adult high grade glioma 4 | 3,801
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
primitive neuroectodermal tumor 4 | 3,035
Brain Ischemia 3 | 110
Electroencephalogram abnormal 3 | 101
Failure to thrive in infancy 3 | 32
Macrotia 3 | 87
Melanoma 3 | 711
Myopia 3 | 176
medulloblastoma 3 | 720

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Transcription Factor 10 | 1,400
Kinase 7 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Friend leukemia integration 1 transcription factor FLI1 Tbio Transcription Factor -1.82504 66.8 454
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
ETS domain-containing protein Elk-3 ELK3 Tbio Transcription Factor -0.17124 0.86 225
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Transcriptional regulator ERG ERG Tchem Transcription Factor -1.19111 12.3 398
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Protein C-ets-1 ETS1 Tbio Transcription Factor -2.89500 760.0 463
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Protein C-ets-2 ETS2 Tbio Transcription Factor -2.40902 253.3 272