Development Level

Tbio 6 | 11,445
Tchem 6 | 1,598

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Cancer 9 | 2,499
Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
glioblastoma 7 | 5,792
atypical teratoid / rhabdoid tumor 4 | 5,112
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Brain Ischemia 3 | 110
Immunologic Deficiency Syndromes 3 | 113
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Multiple myeloma 3 | 1,332
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
group 4 medulloblastoma 3 | 1,855
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
oligodendroglioma 3 | 2,850
primary pancreatic ductal adenocarcinoma 3 | 1,109
Acquired scoliosis 2 | 281
Agammaglobulinemia 2 | 34
Arthritis 2 | 290
Astrocytoma, Pilocytic 2 | 3,081
Attention deficit hyperactivity disorder 2 | 278
Autosomal recessive predisposition 2 | 1,442
Breast Neoplasms 2 | 445
Cell Transformation, Neoplastic 2 | 97
Cholestasis, Extrahepatic 2 | 25
Colonic Neoplasms 2 | 142
Curvature of spine 2 | 282
Dental abnormalities 2 | 60
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Ectodermal dysplasia, hypohidrotic, with immune deficiency 2 | 2
Flexion contracture of proximal interphalangeal joint 2 | 75
Frontal bossing 2 | 157
Heat Stroke 2 | 13
Hypertension 2 | 396
Hypodontia 2 | 81
Hypohidrotic ectodermal dysplasia with immunodeficiency 2 | 2
Infantile onset 2 | 238
Inflammatory bowel disease 2 | 151
Kidney Failure, Chronic 2 | 46
Lack of sweat glands 2 | 2
Mammary Neoplasms 2 | 425
Mantle cell lymphoma 2 | 23
Neoplastic Cell Transformation 2 | 89
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Short stature 2 | 531
Small head 2 | 374
Sparse hair 2 | 59
Thin, sparse hair 2 | 59
Tooth Abnormalities 2 | 69
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
esophageal adenocarcinoma 2 | 737
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
non-small cell lung cancer 2 | 2,890
subependymal giant cell astrocytoma 2 | 2,287
Agenesis of teeth 1 | 21
Anemia, Hemolytic 1 | 55
Anhidrosis 1 | 23
Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 1 | 1
Atypical Mycobacteriosis, Familial, X-Linked 1 1 | 1
Barrett Esophagus 1 | 16
Biliary cirrhosis 1 | 45
Brain Neoplasms 1 | 33
Brain cancer 1 | 30
Bronchiectasis 1 | 64
Chronic Obstructive Airway Disease 1 | 37
Congenital sensorineural hearing loss 1 | 12
Diabetic Nephropathy 1 | 34
Hamman-Rich syndrome 1 | 34
Hearing abnormality 1 | 12
Hyperglycemia 1 | 137
Impaired memory B-cell generation 1 | 3
Incontinentia Pigmenti 1 | 1
Incontinentia pigmenti syndrome 1 | 1
Invasive pneumococcal disease, recurrent isolated, 2 1 | 1
Liver Cirrhosis, Biliary 1 | 33
Mitral regurgitation, mild 1 | 32
Neoplasms, Experimental 1 | 40
Neuronal ceroid lipofuscinosis 1 1 | 15
Ovarian Cysts 1 | 41
Peg shaped front tooth 1 | 6
Pointed front tooth 1 | 6
Recurrent bronchitis 1 | 23
Reduced number of teeth 1 | 21
Saddle nose 1 | 6
Short thumb terminal phalanx 1 | 5
Skin Abnormalities 1 | 37
Skin Neoplasms 1 | 69
Syndactyly of fingers 1 | 48
ulnar-mammary syndrome 1 | 8

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 5 | 12,091
Kinase 4 | 634
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B inhibitor epsilon NFKBIE Tbio Non-IDG -1.39025 20.6 313
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34987 1979.8 1300
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.36360 203.6 1101
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215
F-box/WD repeat-containing protein 1A BTRC Tbio Non-IDG -2.39662 218.7 218