Development Level

Tbio 169 | 11,445
Tchem 41 | 1,598
Tclin 22 | 613
Tdark 3 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 979
decreased vertical activity 8 | 208
enlarged heart 8 | 210
embryonic lethality prior to t... 7 | 278
abnormal heart morphology 5 | 162
increased total body fat amoun... 5 | 134
preweaning lethality, incomple... 5 | 499
cataract 4 | 92
decreased bone mineral content 4 | 151
decreased lean body mass 4 | 135
limb grasping 4 | 41
decreased body weight 3 | 161
decreased fasted circulating g... 3 | 65
embryonic lethality prior to o... 3 | 239
impaired glucose tolerance 3 | 75
impaired pupillary reflex 3 | 26
improved glucose tolerance 3 | 79
increased circulating choleste... 3 | 66
increased circulating iron lev... 3 | 30
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
abnormal testis morphology 2 | 43
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased startle reflex 2 | 75
edema 2 | 59
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hypoactivity 2 | 132
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased leukocyte cell numbe... 2 | 47
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
male infertility 2 | 123
microphthalmia 2 | 26
short tibia 2 | 97
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal whole-body plethysmog... 1 | 4
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
female infertility 1 | 60
hemorrhage 1 | 23
hydroencephaly 1 | 14
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean platelet volume 1 | 45
iris synechia 1 | 3
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged RR interval 1 | 8
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Cancer 124 | 2,499
Carcinoma 122 | 11,493
psoriasis 109 | 6,694
lung cancer 76 | 4,740
glioblastoma 69 | 5,792
osteosarcoma 69 | 7,950
ependymoma 67 | 4,679
ovarian cancer 67 | 8,520
medulloblastoma, large-cell 63 | 6,241
Schizophrenia 61 | 1,160
malignant mesothelioma 60 | 3,232
diabetes mellitus 59 | 1,728
atypical teratoid / rhabdoid tumor 58 | 5,112
group 3 medulloblastoma 54 | 4,104
Breast cancer 52 | 3,578
Astrocytoma, Pilocytic 51 | 3,081
lung carcinoma 50 | 2,843
interstitial cystitis 48 | 2,312
adult high grade glioma 45 | 3,801
oligodendroglioma 45 | 2,850
Depressive disorder 44 | 409
Obesity 44 | 678
Asthma 42 | 385
Bipolar Disorder 41 | 666
Kidney disease 41 | 430
Hypertension 40 | 396
lung adenocarcinoma 40 | 2,716
tuberculosis 40 | 2,010
Autosomal recessive predisposition 38 | 1,442
cystic fibrosis 38 | 1,696
Mental Depression 36 | 333
non-small cell lung cancer 36 | 2,890
pituitary cancer 36 | 1,972
ulcerative colitis 35 | 1,819
invasive ductal carcinoma 34 | 2,951
astrocytic glioma 33 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
Alcoholic Intoxication, Chronic 32 | 289
Arthritis 32 | 290
Liver Cirrhosis, Experimental 32 | 769
Major Depressive Disorder 32 | 301
primitive neuroectodermal tumor 32 | 3,035
Rheumatoid arthritis 31 | 1,191
Breast Neoplasms 30 | 445
Heart disease 30 | 306
Hypertensive disease 30 | 292
Mammary Neoplasms 30 | 425
colon cancer 30 | 1,478
Autistic Disorder 29 | 364
Osteoporosis 29 | 363
Unipolar Depression 29 | 250
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
pancreatic cancer 29 | 2,398
Diarrhea 28 | 253
Inflammatory bowel disease 28 | 151
Seizures 28 | 596
Anemia 27 | 365
Hypersensitivity reaction type II disease 27 | 253
Cerebrovascular disease 26 | 238
Hypotension 26 | 82
Pulmonary Fibrosis 26 | 106
Inflammation 25 | 120
Lung disease 25 | 142
Multiple Sclerosis 25 | 540
Atherosclerosis 24 | 291
Parkinson's disease 24 | 392
Prostatic Neoplasms 24 | 495
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Adenoma 23 | 167
Alzheimer's disease 23 | 658
Coronary artery disease 23 | 268
Hyperalgesia 23 | 83
Mood Disorders 23 | 184
cutaneous lupus erythematosus 23 | 1,057
Endometriosis 22 | 540
Hyperglycemia 22 | 137
Hypoglycemia 22 | 152
Pain 22 | 103
Vascular disease 22 | 319
ductal carcinoma in situ 22 | 1,745
Allergic hypersensitivity disease 21 | 126
Liver disease 21 | 237
Neuropathy 21 | 261
Polycystic ovary syndrome 21 | 360
breast carcinoma 21 | 1,638
Cleft Palate 20 | 271
Epilepsy 20 | 792
Infertility 20 | 188
Kidney cancer 20 | 2,613
subependymal giant cell astrocytoma 20 | 2,287
Dermatitis 19 | 157
Melanoma 19 | 711
Pancreatitis 19 | 123
Reperfusion Injury 19 | 86
Short stature 19 | 531
Heart failure 18 | 162
Intellectual disability 18 | 1,016
Liver Cirrhosis 18 | 181
Liver carcinoma 18 | 240
Pneumonia 18 | 174

Tissue

Endocrine System 216 | 18,159
Female tissues 206 | 17,400
Digestive Tract 205 | 17,369
Skin and soft tissues 200 | 17,230
Blood and immune system 196 | 16,909
Nervous System 195 | 16,725
Male tissues 193 | 17,142
Liver and Pancreas 191 | 16,750
Urinary Tract 190 | 16,678
Respiratory system 186 | 16,393
Cardiovascular System 148 | 15,192

Target Family

Non-IDG 191 | 12,091
GPCR 31 | 408
Kinase 12 | 634
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305