Development Level

Tbio 26 | 11,445
Tchem 21 | 1,598
Tclin 11 | 613
Tdark 2 | 6,588

IMPC Phenotype

abnormal behavior 2 | 298
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased mean corpuscular vol... 2 | 79
hypoactivity 2 | 132
preweaning lethality, complete... 2 | 979
abnormal QT variability 1 | 10
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal startle reflex 1 | 15
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating lipase l... 1 | 3
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 52 | 11,493
psoriasis 35 | 6,694
lung cancer 27 | 4,740
ovarian cancer 25 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
osteosarcoma 22 | 7,950
interstitial cystitis 20 | 2,312
Cancer 19 | 2,499
medulloblastoma, large-cell 18 | 6,241
invasive ductal carcinoma 17 | 2,951
lung carcinoma 17 | 2,843
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
glioblastoma 14 | 5,792
lung adenocarcinoma 14 | 2,716
non-small cell lung cancer 14 | 2,890
pituitary cancer 14 | 1,972
Prostatic Neoplasms 13 | 495
Schizophrenia 13 | 1,160
breast carcinoma 13 | 1,638
ependymoma 13 | 4,679
tuberculosis 13 | 2,010
Breast cancer 12 | 3,578
adult high grade glioma 12 | 3,801
atypical teratoid / rhabdoid tumor 12 | 5,112
Autosomal recessive predisposition 11 | 1,442
Liver disease 11 | 237
Major Depressive Disorder 11 | 301
Unipolar Depression 11 | 250
colon cancer 11 | 1,478
cutaneous lupus erythematosus 11 | 1,057
malignant mesothelioma 11 | 3,232
ulcerative colitis 11 | 1,819
Alcoholic Intoxication, Chronic 10 | 289
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pancreatic cancer 10 | 2,398
Chemical and Drug Induced Liver Injury 9 | 195
Depressive disorder 9 | 409
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
group 3 medulloblastoma 9 | 4,104
Atopic dermatitis 8 | 952
Bipolar Disorder 8 | 666
Breast Neoplasms 8 | 445
Hypertension 8 | 396
Liver Cirrhosis, Experimental 8 | 769
Mammary Neoplasms 8 | 425
Mental Depression 8 | 333
diabetes mellitus 8 | 1,728
Alcohol dependence 7 | 107
Astrocytoma, Pilocytic 7 | 3,081
Autistic Disorder 7 | 364
Epilepsy 7 | 792
Obesity 7 | 678
active Crohn's disease 7 | 922
esophageal adenocarcinoma 7 | 737
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
Cognitive delay 6 | 608
Endometriosis 6 | 540
Global developmental delay 6 | 608
Hepatomegaly 6 | 285
Melanoma 6 | 711
Mental and motor retardation 6 | 608
Parkinson's disease 6 | 392
chronic rhinosinusitis 6 | 512
nephrosclerosis 6 | 333
primary Sjogren syndrome 6 | 735
substance-related disorder 6 | 162
Alzheimer's disease 5 | 658
Attention deficit hyperactivity disorder 5 | 278
Cholestasis 5 | 155
Drug-Related Side Effects and Adverse Reactions 5 | 62
Hypotension 5 | 82
Intellectual disability 5 | 1,016
Kidney cancer 5 | 2,613
Malaria 5 | 160
Muscle hypotonia 5 | 571
Parkinson Disease 5 | 64
Succinic semialdehyde dehydrogenase deficiency 5 | 16
acute myeloid leukemia 5 | 783
aldosterone-producing adenoma 5 | 665
group 4 medulloblastoma 5 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 5 | 239
Dull intelligence 4 | 645
Kidney disease 4 | 430
Low intelligence 4 | 645
Lung Neoplasms 4 | 232
Male infertility 4 | 206
Mental deficiency 4 | 645
Mood Disorders 4 | 184
Pellagra 4 | 26
Poor school performance 4 | 645
Psychotic Disorders 4 | 151
active ulcerative colitis 4 | 764
acute quadriplegic myopathy 4 | 1,158
fibroadenoma 4 | 559
juvenile dermatomyositis 4 | 1,187
nasopharyngeal carcinoma 4 | 1,058

Tissue

Digestive Tract 58 | 17,369
Female tissues 58 | 17,400
Liver and Pancreas 58 | 16,750
Endocrine System 57 | 18,159
Respiratory system 56 | 16,393
Skin and soft tissues 56 | 17,230
Male tissues 55 | 17,142
Blood and immune system 54 | 16,909
Urinary Tract 54 | 16,678
Nervous System 50 | 16,725
Cardiovascular System 44 | 15,192

Target Family

Enzyme 40 | 4,145
Non-IDG 19 | 12,091
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phylloquinone omega-hydroxylase CYP4F11 CYP4F11 Tbio Enzyme -0.71213 6.60 96
4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 Tbio Enzyme -1.43954 27.0 162
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.14670 1303.9 150
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Transcriptional repressor NF-X1 NFX1 Tbio Transcription Factor -1.34294 23.4 111
Cytochrome P450 4F8 CYP4F8 Tdark Non-IDG 0.00000 34
Cytochrome P450 2D6 CYP2D6 Tclin Enzyme -3.53105 3484.9 433
Cytochrome P450 2C8 CYP2C8 Tchem Non-IDG -2.55207 348.9 159