Development Level

Tbio 29 | 11,445
Tchem 8 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased hemoglobin content 1 | 68
increased heart weight 1 | 62
increased prepulse inhibition 1 | 32
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

ovarian cancer 36 | 8,520
Multiple myeloma 25 | 1,332
Carcinoma 20 | 11,493
psoriasis 19 | 6,694
osteosarcoma 18 | 7,950
lung cancer 15 | 4,740
glioblastoma 13 | 5,792
Cancer 11 | 2,499
HIV Infections 11 | 102
Breast cancer 9 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Waldenstrons macroglobulinemia 8 | 765
atypical teratoid / rhabdoid tumor 8 | 5,112
dermatomyositis 8 | 966
adult high grade glioma 7 | 3,801
ependymoma 7 | 4,679
lung carcinoma 7 | 2,843
Astrocytoma, Pilocytic 6 | 3,081
astrocytoma 6 | 1,146
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
malignant mesothelioma 6 | 3,232
medulloblastoma, large-cell 6 | 6,241
Mantle cell lymphoma 5 | 23
Pick disease 5 | 1,894
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
non primary Sjogren syndrome sicca 5 | 891
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
active Crohn's disease 4 | 922
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
primary Sjogren syndrome 4 | 735
tuberculosis 4 | 2,010
Anemia 3 | 365
Fibrodysplasia ossificans progressiva 3 | 17
Hereditary hemorrhagic telangiectasia 3 | 13
Liver Cirrhosis, Experimental 3 | 769
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
hepatocellular carcinoma 3 | 547
interstitial cystitis 3 | 2,312
juvenile dermatomyositis 3 | 1,187
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Autosomal recessive predisposition 2 | 1,442
Bilateral fifth finger clinodactyly 2 | 110
Bunion 2 | 26
Cardiomegaly 2 | 116
Colorectal Neoplasms 2 | 243
Congenital clubfoot 2 | 109
Congestive heart failure 2 | 113
Craniofacial Abnormalities 2 | 151
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Decreased joint mobility 2 | 53
Eye Abnormalities 2 | 35
Failure to gain weight 2 | 365
Flexion contracture of proximal interphalangeal joint 2 | 75
Hallux Valgus 2 | 26
Heart disease 2 | 306
Hemoglobin low 2 | 124
Hydrolethalus syndrome 2 | 128
Hypertensive disease 2 | 292
Increase in blood pressure 2 | 119
Iron-Refractory Iron Deficiency Anemia 2 | 15
Joint stiffness 2 | 84
Kidney cancer 2 | 2,613
Liver Cirrhosis 2 | 181
Multiple, subcutaneous nodules 2 | 53
Osteoporosis 2 | 363
Pediatric failure to thrive 2 | 365
Primary pulmonary hypertension 2 | 14
Prostate cancer 2 | 175
Pulmonary Fibrosis 2 | 106
Short hallux 2 | 16
Subcutaneous nodule 2 | 53
Systemic scleroderma 2 | 60
Ureteral obstruction 2 | 33
active ulcerative colitis 2 | 764
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 459
pituitary cancer 2 | 1,972
Hamartoma Syndrome, Multiple 1 | 10
Hypoplastic finger 1 | 17
Metaphyseal widening 1 | 22
Pericardial effusion 1 | 14
Photosensitive trichothiodystrophy 1 | 30
Short finger 1 | 17
Short phalanx of finger 1 | 32
Toe contractures 1 | 5

Tissue

Blood and immune system 43 | 16,909
Cardiovascular System 43 | 15,192
Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678

Target Family

Enzyme 36 | 4,145
Kinase 6 | 634
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Proteasome subunit alpha type-7 PSMA7 Tbio Enzyme -2.71627 496.7 288
Proteasome subunit alpha type-6 PSMA6 Tbio Enzyme -2.80973 614.4 288
26S proteasome non-ATPase regulatory subunit 11 PSMD11 Tbio Enzyme -1.13234 13.3 211
Bone morphogenetic protein receptor type-1B BMPR1B Tchem Kinase -2.00303 86.8 498
Proteasome subunit alpha type-3 PSMA3 Tbio Enzyme -1.20981 15.8 181
Proteasome subunit alpha type-4 PSMA4 Tbio Enzyme -1.01237
Proteasome subunit alpha type-2 PSMA2 Tbio Enzyme -0.82346 5.78 245
Activin receptor type-1B ACVR1B Tchem Kinase -2.00550 91.2 418
Bone morphogenetic protein receptor type-1A BMPR1A Tchem Kinase -2.34984 211.0 622