Development Level

Tbio 46 | 11,445
Tchem 10 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal heart morphology 4 | 162
enlarged heart 4 | 210
abnormal bone mineralization 2 | 38
cataract 2 | 92
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
edema 2 | 59
increased startle reflex 2 | 112
mammalian phenotype 2 | 17
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal coat-hair pigmentatio... 1 | 64
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hydroencephaly 1 | 14
hyperactivity 1 | 148
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
kinked tail 1 | 2
mydriasis 1 | 6
small heart 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 40 | 11,493
psoriasis 35 | 6,694
Cancer 29 | 2,499
ovarian cancer 29 | 8,520
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 24 | 5,112
medulloblastoma, large-cell 23 | 6,241
osteosarcoma 22 | 7,950
ependymoma 21 | 4,679
Breast cancer 20 | 3,578
Astrocytoma, Pilocytic 19 | 3,081
interstitial cystitis 16 | 2,312
invasive ductal carcinoma 16 | 2,951
lung cancer 16 | 4,740
pancreatic cancer 16 | 2,398
lung adenocarcinoma 15 | 2,716
non-small cell lung cancer 15 | 2,890
astrocytic glioma 14 | 2,597
adult high grade glioma 13 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
malignant mesothelioma 13 | 3,232
oligodendroglioma 13 | 2,850
primitive neuroectodermal tumor 13 | 3,035
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
primary pancreatic ductal adenocarcinoma 12 | 1,109
Osteoporosis 11 | 363
cutaneous lupus erythematosus 11 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung carcinoma 11 | 2,843
cystic fibrosis 10 | 1,696
group 3 medulloblastoma 10 | 4,104
group 4 medulloblastoma 10 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pituitary cancer 10 | 1,972
Duchenne muscular dystrophy 9 | 601
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
diabetes mellitus 9 | 1,728
juvenile dermatomyositis 9 | 1,187
pediatric high grade glioma 9 | 1,064
Autosomal recessive predisposition 8 | 1,442
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
dermatomyositis 8 | 966
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Obesity 7 | 678
Pick disease 7 | 1,894
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Kidney cancer 6 | 2,613
Parkinson's disease 6 | 392
Short stature 6 | 531
acute quadriplegic myopathy 6 | 1,158
colon cancer 6 | 1,478
gastric carcinoma 6 | 807
non primary Sjogren syndrome sicca 6 | 891
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Acquired scoliosis 5 | 281
Breast Neoplasms 5 | 445
Cleft Palate 5 | 271
Colorectal Neoplasms 5 | 243
Curvature of spine 5 | 282
Multiple myeloma 5 | 1,332
Orbital separation excessive 5 | 244
Rheumatoid arthritis 5 | 1,191
esophageal adenocarcinoma 5 | 737
limb girdle muscular dystrophy 2A 5 | 213
medulloblastoma 5 | 720
osteoporosis-pseudoglioma syndrome 5 | 9
sonic hedgehog group medulloblastoma 5 | 467
Adenoma 4 | 167
Broad flat nasal bridge 4 | 236
Cognitive delay 4 | 608
Congenital diaphragmatic hernia 4 | 67
Downward slant of palpebral fissure 4 | 158
Gait abnormality 4 | 135
Global developmental delay 4 | 608
Heart conduction disease 4 | 83
Juvenile osteoporosis 4 | 4
Kidney disease 4 | 430
Low set ears 4 | 181
Mammary Neoplasms 4 | 425
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Nasal bridge wide 4 | 236
Neoplasm Metastasis 4 | 168
Osteoarthritis 4 | 184
Prostatic Neoplasms 4 | 495
Short neck 4 | 140
Tooth agenesis 4 | 44
chronic rhinosinusitis 4 | 512
fascioscapulohumeral muscular dystrophy 4 | 100
nephrosclerosis 4 | 333
non diabetic and post-ischemic heart failure 4 | 200
sarcoidosis 4 | 370

Tissue

Female tissues 55 | 17,400
Digestive Tract 54 | 17,369
Endocrine System 54 | 18,159
Nervous System 54 | 16,725
Blood and immune system 53 | 16,909
Male tissues 53 | 17,142
Skin and soft tissues 53 | 17,230
Urinary Tract 52 | 16,678
Liver and Pancreas 50 | 16,750
Respiratory system 48 | 16,393
Cardiovascular System 43 | 15,192

Target Family

Non-IDG 49 | 12,091
Transcription Factor 4 | 1,400
Kinase 2 | 634
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 56 | 56
http://pathwaycommons.org/pc2/... 236 | 236
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Secreted frizzled-related protein 3 FRZB Tbio Non-IDG -2.51623 308.4 252
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Syndecan-3 SDC3 Tbio Non-IDG -1.86172 78.8 179
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387
Protein Wnt-5b WNT5B Tbio Non-IDG -1.62833 40.2 161