Development Level

Tchem 10 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46

Disease

Carcinoma 12 | 11,493
glioblastoma 10 | 5,792
atypical teratoid / rhabdoid tumor 9 | 5,112
ovarian cancer 9 | 8,520
Cancer 8 | 2,499
osteosarcoma 7 | 7,950
adult high grade glioma 6 | 3,801
lung cancer 6 | 4,740
medulloblastoma, large-cell 6 | 6,241
psoriasis 6 | 6,694
Vascular disease 5 | 319
Cholestasis, Extrahepatic 4 | 25
Kidney cancer 4 | 2,613
diabetes mellitus 4 | 1,728
ependymoma 4 | 4,679
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Acquired scoliosis 3 | 281
Astrocytoma, Pilocytic 3 | 3,081
Brain Ischemia 3 | 110
Breast cancer 3 | 3,578
Byzanthine arch palate 3 | 194
Cardiofaciocutaneous syndrome 3 | 15
Costello Syndrome 3 | 17
Curvature of spine 3 | 282
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Noonan syndrome 3 | 34
Orbital separation excessive 3 | 244
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Poor school performance 3 | 645
Precancerous Conditions 3 | 80
Reperfusion Injury 3 | 86
Schizophrenia 3 | 1,160
Short stature 3 | 531
Toxic encephalopathy 3 | 141
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
Absence of eyebrows 2 | 31
Aplasia/Hypoplasia of the eyebrow 2 | 31
Atrial Septal Defects 2 | 85
Big calvaria 2 | 147
Blepharoptosis 2 | 231
Brain disease 2 | 96
Breast Neoplasms 2 | 445
Cardiomyopathy 2 | 116
Coarse facial features 2 | 108
Colonic Neoplasms 2 | 142
Disease Models, Animal 2 | 155
Electroencephalogram abnormal 2 | 101
Frontal bossing 2 | 157
Hemangioma, Cavernous 2 | 20
High forehead 2 | 102
Hyperalgesia 2 | 83
Hyperhidrosis disorder 2 | 81
Hypertrophic Cardiomyopathy 2 | 117
Ichthyoses 2 | 41
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Increased sweating 2 | 81
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver disease 2 | 237
Low posterior hairline 2 | 52
Macrotia 2 | 87
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Myopia 2 | 176
Neurodegenerative disease 2 | 414
Premature Birth 2 | 77
Premature birth of newborn 2 | 67
Sensorineural Hearing Loss (disorder) 2 | 284
Skin hyperelastic 2 | 32
Sparse hair 2 | 59
Sparse or absent eyebrows 2 | 31
Sparse/absent eyebrows 2 | 31
Sweating 2 | 81
Tall forehead 2 | 102
Thickened facial skin with coarse facial features 2 | 108
Thin, sparse hair 2 | 59
Underdeveloped brows 2 | 38
Underdeveloped supraorbital ridges 2 | 38

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Kinase 11 | 634
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 236 | 236
http://pathwaycommons.org/pc2/... 235 | 235
http://pathwaycommons.org/pc2/... 233 | 233
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http://pathwaycommons.org/pc2/... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.83744 60.9 883
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Mitogen-activated protein kinase 8 MAPK8 Tchem Kinase -3.81256 5770.8 1150