Development Level

Tchem 119 | 1,890
Tclin 37 | 602
Tbio 26 | 10,625
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 13 | 134

IMPC Term

preweaning lethality, complete... 14 | 633
preweaning lethality, incomple... 8 | 260
decreased body weight 5 | 174
decreased bone mineral content 5 | 157
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
abnormal bone structure 4 | 131
abnormal embryo size 4 | 112
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
abnormal lens morphology 3 | 73
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased fasted circulating g... 3 | 49
enlarged heart 3 | 111
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
abnormal bone mineralization 2 | 55
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
anophthalmia 2 | 20
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating creatini... 2 | 31
decreased circulating iron lev... 2 | 25
decreased circulating triglyce... 2 | 83
decreased lumbar vertebrae num... 2 | 62
enlarged spleen 2 | 26
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating LDL chol... 2 | 15
increased circulating iron lev... 2 | 25
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased mean corpuscular hem... 2 | 93
increased or absent threshold ... 2 | 128
male infertility 2 | 62
microphthalmia 2 | 15
small superior vagus ganglion 2 | 20
small testis 2 | 37
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
absent vibrissae 1 | 14
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating glycerol... 1 | 19
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 16
increased effector memory T-he... 1 | 5
increased eosinophil cell numb... 1 | 9
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 19
increased memory-marker gamma-... 1 | 2
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
short tibia 1 | 82
small adrenal glands 1 | 15
thrombocytosis 1 | 23
tremors 1 | 34

Disease

osteosarcoma 113 | 7,933
ovarian cancer 108 | 8,484
Cancer 95 | 2,346
medulloblastoma, large-cell 93 | 6,234
glioblastoma 90 | 5,572
psoriasis 84 | 6,685
atypical teratoid / rhabdoid tumor 69 | 4,369
lung cancer 66 | 4,466
malignant mesothelioma 54 | 3,162
pilocytic astrocytoma 54 | 3,086
Carcinoma 49 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
ependymoma 46 | 2,514
non-small cell lung cancer 46 | 2,798
oligodendroglioma 46 | 2,849
primitive neuroectodermal tumor 46 | 3,031
Breast cancer 45 | 3,094
invasive ductal carcinoma 40 | 2,950
lung carcinoma 38 | 2,844
pediatric high grade glioma 38 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
ulcerative colitis 35 | 2,087
adult high grade glioma 33 | 2,148
subependymal giant cell astrocytoma 33 | 2,287
interstitial cystitis 32 | 2,299
lung adenocarcinoma 32 | 2,713
astrocytoma 30 | 1,493
tuberculosis 30 | 1,557
Pick disease 28 | 1,893
group 4 medulloblastoma 28 | 1,875
astrocytic glioma 27 | 2,241
medulloblastoma 27 | 1,524
pancreatic cancer 27 | 2,300
Rheumatoid Arthritis 25 | 1,160
adrenocortical carcinoma 25 | 1,427
cystic fibrosis 25 | 1,665
pituitary cancer 25 | 1,972
group 3 medulloblastoma 24 | 2,254
Renal Cell Carcinoma 23 | 199
breast carcinoma 23 | 1,614
diabetes mellitus 23 | 1,663
colon cancer 22 | 1,475
ductal carcinoma in situ 22 | 1,745
Mammary Neoplasms 21 | 410
Prostatic Neoplasms 18 | 471
posterior fossa group A ependymoma 18 | 1,511
sonic hedgehog group medulloblastoma 18 | 1,482
Alzheimer's disease 17 | 644
Vascular disease 17 | 281
Obesity 16 | 616
Schizophrenia 16 | 501
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
primary pancreatic ductal adenocarcinoma 16 | 1,271
spina bifida 16 | 1,064
Hamman-Rich syndrome 15 | 35
Lung Neoplasms 15 | 171
acute myeloid leukemia 15 | 780
juvenile dermatomyositis 15 | 1,189
non-small cell lung carcinoma 15 | 413
primary Sjogren syndrome 15 | 789
Parkinson's disease 14 | 364
Waldenstrons macroglobulinemia 14 | 765
cutaneous lupus erythematosus 14 | 1,056
posterior fossa group B ependymoma 14 | 1,530
Blastic phase chronic myeloid leukemia 13 | 58
Chronic Myelocytic Leukemia Accelerated Phase 13 | 59
acute quadriplegic myopathy 13 | 1,157
atypical teratoid/rhabdoid tumor 13 | 1,095
Gastrointestinal stromal tumor 12 | 61
Stomach Neoplasms 12 | 282
Heart disease 11 | 279
Intellectual disability 11 | 573
Melanoma 11 | 261
Pancreatic Neuroendocrine Tumor 11 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 11 | 47
dermatomyositis 11 | 933
nasopharyngeal carcinoma 11 | 1,056
Arthritis 10 | 248
Asthma 10 | 349
Carcinoma of thyroid 10 | 17
Cardiomyopathies 10 | 90
Chronic phase chronic myeloid leukemia 10 | 45
Multiple myeloma 10 | 1,327
Neoplasm Metastasis 10 | 138
Papillary thyroid carcinoma 10 | 37
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 10 | 45
Sarcoma of soft tissue 10 | 11
Atopic dermatitis 9 | 944
Bipolar Disorder 9 | 266
Colorectal Neoplasms 9 | 217
Craniofacial Abnormalities 9 | 147
Gout 9 | 93
Hyperalgesia 9 | 71
Kidney disease 9 | 396
Squamous cell carcinoma 9 | 94
Toxic encephalopathy 9 | 131
esophageal adenocarcinoma 9 | 737
pancreatic carcinoma 9 | 567
aldosterone-producing adenoma 8 | 664

Tissue

Blood and immune system 183 | 17,995
Female tissues 183 | 18,647
Liver and Pancreas 183 | 18,136
Nervous System 183 | 18,561
Cardiovascular System 182 | 17,958
Digestive Tract 182 | 18,473
Endocrine System 182 | 18,512
Male tissues 182 | 17,969
Urinary Tract 182 | 18,444
Respiratory system 181 | 17,484
Skin and soft tissues 180 | 18,115

Target Family

Kinase 164 | 634
Enzyme 10 | 4,146
Non-IDG 9 | 11,971

PathwayCommons: inoh Pathway

VEGF signaling pathway ( VEGF ... 183 | 183
Drosophila Toll-like receptor ... 236 | 236
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
TGF beta receptor complex degr... 48 | 48
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
TGF beta receptor I degradatio... 43 | 43
Inositol phosphate metabolism ... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 38 | 38
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.59340 415.3 337
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.28652 191.1 505
Cyclin-H CCNH Tbio Non-IDG -1.98840 89.8 354