Development Level

Tbio 18 | 10,625
Tchem 15 | 1,890
Tdark 6 | 7,003
Tclin 4 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 30
decreased B cell number 1 | 30
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased lean body mass 1 | 195
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
small testis 1 | 37

Disease

lung carcinoma 16 | 2,844
lung cancer 15 | 4,466
interstitial cystitis 13 | 2,299
osteosarcoma 13 | 7,933
cutaneous lupus erythematosus 12 | 1,056
diabetes mellitus 12 | 1,663
ovarian cancer 11 | 8,484
Rheumatoid Arthritis 10 | 1,160
invasive ductal carcinoma 10 | 2,950
primary Sjogren syndrome 10 | 789
psoriasis 10 | 6,685
Cancer 9 | 2,346
glioblastoma 9 | 5,572
ulcerative colitis 8 | 2,087
breast carcinoma 7 | 1,614
subependymal giant cell astrocytoma 7 | 2,287
Hypersensitivity reaction type II disease 6 | 235
Multiple Sclerosis 6 | 498
Type 1 diabetes mellitus 6 | 101
Asthma 5 | 349
Carcinoma 5 | 2,147
Celiac disease 5 | 112
Diabetes Mellitus, Insulin-Dependent 5 | 76
Juvenile rheumatoid arthritis 5 | 104
Narcolepsy 5 | 58
Systemic scleroderma 5 | 66
Waldenstrons macroglobulinemia 5 | 765
adult high grade glioma 5 | 2,148
medulloblastoma, large-cell 5 | 6,234
non-small cell lung cancer 5 | 2,798
sarcoidosis 5 | 358
tuberculosis 5 | 1,557
Chronic Lymphocytic Leukemia 4 | 242
Duchenne muscular dystrophy 4 | 602
Hepatitis B, Chronic 4 | 15
Hypersensitivity 4 | 63
Liver diseases 4 | 66
Multiple myeloma 4 | 1,327
Severe Combined Immunodeficiency 4 | 46
Urticaria 4 | 53
active Crohn's disease 4 | 918
astrocytoma 4 | 1,493
dermatomyositis 4 | 933
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
juvenile dermatomyositis 4 | 1,189
pediatric high grade glioma 4 | 2,712
pilocytic astrocytoma 4 | 3,086
Addison's disease 3 | 29
Angioedema 3 | 36
Autoimmune thyroiditis 3 | 24
Berylliosis 3 | 16
Graves' disease 3 | 25
IGA Glomerulonephritis 3 | 454
Lupus Erythematosus, Systemic 3 | 73
Membranous glomerulonephritis 3 | 11
Neoplastic Cell Transformation 3 | 81
Pre B-cell acute lymphoblastic leukemia 3 | 4
Renal transplant rejection 3 | 13
active ulcerative colitis 3 | 477
atypical teratoid / rhabdoid tumor 3 | 4,369
colon cancer 3 | 1,475
cystic fibrosis 3 | 1,665
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
limb girdle muscular dystrophy 2I 3 | 56
malignant mesothelioma 3 | 3,162
pancreatic cancer 3 | 2,300
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271
Adult T-Cell Lymphoma/Leukemia 2 | 30
Atopic dermatitis 2 | 944
Becker muscular dystrophy 2 | 187
Brain Ischemia 2 | 87
Collagen disease 2 | 25
Colonic Neoplasms 2 | 126
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Down syndrome 2 | 548
Drug Eruptions 2 | 18
Drug-Induced Liver Injury 2 | 118
Glanzmann's thrombasthenia 2 | 21
Hepatitis B 2 | 103
Liver disease 2 | 219
Lymphoma 2 | 56
Melanoma 2 | 261
Pick disease 2 | 1,893
Proteinuria 2 | 63
Renal Cell Carcinoma 2 | 199
Vasculitis 2 | 64
adrenocortical carcinoma 2 | 1,427
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
lung adenocarcinoma 2 | 2,713
medulloblastoma 2 | 1,524
nephrosclerosis 2 | 329
pancreatic carcinoma 2 | 567
spina bifida 2 | 1,064
systemic lupus erythematosus 2 | 156
type I diabetes mellitus 2 | 22

Tissue

Blood and immune system 30 | 17,995
Digestive Tract 30 | 18,473
Endocrine System 30 | 18,512
Female tissues 30 | 18,647
Liver and Pancreas 30 | 18,136
Male tissues 30 | 17,969
Nervous System 30 | 18,561
Respiratory system 30 | 17,484
Urinary Tract 30 | 18,444
Cardiovascular System 29 | 17,958
Skin and soft tissues 25 | 18,115

Target Family

Non-IDG 33 | 11,971
Enzyme 5 | 4,146
Kinase 3 | 634
Transcription Factor 2 | 1,400

PathwayCommons: inoh Pathway

T cell receptor signaling path... 43 | 43
Drosophila Toll-like receptor ... 236 | 236
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
TGF beta receptor complex degr... 48 | 48
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
TGF beta receptor I degradatio... 43 | 43
Inositol phosphate metabolism ... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 38 | 38
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

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