Development Level

Tbio 38 | 10,625
Tchem 8 | 1,890
Tdark 1 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 4 | 633
decreased startle reflex 2 | 48
hydrops fetalis 2 | 22
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal response to tactile s... 1 | 16
abnormal startle reflex 1 | 14
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating fructosa... 1 | 31
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased total body fat amoun... 1 | 186
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased lean body mass 1 | 107
microphthalmia 1 | 15
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
syndactyly 1 | 4

Disease

psoriasis 25 | 6,685
osteosarcoma 22 | 7,933
ovarian cancer 21 | 8,492
Cancer 19 | 2,346
atypical teratoid / rhabdoid tumor 18 | 4,369
Breast cancer 14 | 3,099
interstitial cystitis 14 | 2,299
lung cancer 14 | 4,473
medulloblastoma, large-cell 14 | 6,234
glioblastoma 13 | 5,572
primitive neuroectodermal tumor 12 | 3,031
invasive ductal carcinoma 11 | 2,950
Carcinoma 10 | 2,147
breast carcinoma 10 | 1,614
ductal carcinoma in situ 10 | 1,745
lung carcinoma 10 | 2,844
astrocytoma 9 | 1,493
cystic fibrosis 9 | 1,670
ependymoma 9 | 2,514
malignant mesothelioma 9 | 3,163
pediatric high grade glioma 9 | 2,712
pilocytic astrocytoma 9 | 3,086
Osteoporosis 8 | 259
non-small cell lung cancer 8 | 2,798
posterior fossa group A ependymoma 8 | 1,511
acute myeloid leukemia 7 | 785
colon cancer 7 | 1,475
group 3 medulloblastoma 7 | 2,254
group 4 medulloblastoma 7 | 1,875
oligodendroglioma 7 | 2,849
sonic hedgehog group medulloblastoma 7 | 1,482
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
pancreatic cancer 6 | 2,300
pituitary cancer 6 | 1,972
Cleft palate 5 | 125
adrenocortical carcinoma 5 | 1,427
cutaneous lupus erythematosus 5 | 1,056
esophageal adenocarcinoma 5 | 737
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
lung adenocarcinoma 5 | 2,714
non primary Sjogren syndrome sicca 5 | 840
Colonic Neoplasms 4 | 126
Colorectal Neoplasms 4 | 217
Intellectual disability 4 | 573
Mammary Neoplasms 4 | 410
Obesity 4 | 616
Pick disease 4 | 1,893
Rheumatoid Arthritis 4 | 1,171
acute quadriplegic myopathy 4 | 1,157
astrocytic glioma 4 | 2,241
fibroadenoma 4 | 557
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 2,087
AMYOTROPHIC LATERAL SCLEROSIS 1 3 | 49
Adenoid Cystic Carcinoma 3 | 99
Bipolar Disorder 3 | 266
Cleft Lip 3 | 91
Colorectal Cancer 3 | 62
Craniofacial Abnormalities 3 | 147
Crohn's disease 3 | 304
Exudative vitreoretinopathy 3 | 15
Female Urogenital Diseases 3 | 18
Kidney cancer 3 | 121
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 3 | 12
Multiple myeloma 3 | 1,328
Osteoporosis, Juvenile 3 | 4
Peripheral Neuropathy 3 | 303
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 503
Small cell carcinoma of lung 3 | 45
Tooth agenesis 3 | 38
Uterine Cervical Neoplasm 3 | 21
active Crohn's disease 3 | 918
chronic lymphosyte leukemia 3 | 232
diabetes mellitus 3 | 1,663
gastric carcinoma 3 | 832
non-inflammatory breast cancer 3 | 208
ovarian neoplasm 3 | 97
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
tuberculosis 3 | 1,563
Adenoma 2 | 165
Alzheimer's disease 2 | 644
Atopic dermatitis 2 | 944
Kidney disease 2 | 397
Type 2 diabetes mellitus 2 | 192
Waldenstrons macroglobulinemia 2 | 765
aldosterone-producing adenoma 2 | 664
atypical teratoid/rhabdoid tumor 2 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
chronic rhinosinusitis 2 | 512
dermatomyositis 2 | 967
glioblastoma multiforme 2 | 347
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
progressive supranuclear palsy 2 | 674
spina bifida 2 | 1,064
tuberculosis and treatment for 3 months 2 | 327
urothelial carcinoma 2 | 318

Tissue

Digestive Tract 47 | 18,473
Endocrine System 47 | 18,512
Female tissues 47 | 18,647
Male tissues 47 | 17,969
Nervous System 47 | 18,561
Respiratory system 47 | 17,484
Skin and soft tissues 47 | 18,115
Urinary Tract 47 | 18,444
Blood and immune system 46 | 17,995
Liver and Pancreas 46 | 18,136
Cardiovascular System 45 | 17,958

Target Family

Non-IDG 27 | 11,969
GPCR 10 | 408
Epigenetic 5 | 242
Transcription Factor 5 | 1,400

PathwayCommons: inoh Pathway

Signaling with Wnt (Canonical)... 47 | 47
Drosophila Toll-like receptor ... 236 | 236
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
TGF beta receptor complex degr... 48 | 48
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
TGF beta receptor I degradatio... 43 | 43
Inositol phosphate metabolism ... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 38 | 38
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pygopus homolog 2 PYGO2 Tbio Epigenetic -1.22853 25.3 76
Pygopus homolog 1 PYGO1 Tdark Epigenetic -0.48368 2.66 111
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.12904 1149.7 572
Frizzled-5 FZD5 Tbio GPCR -1.49711 28.9 256
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.57942 352.4 554
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Protein Wnt-6 WNT6 Tbio Non-IDG -1.61704 43.1 156
Frizzled-1 FZD1 Tbio GPCR -2.04125 74.3 233
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.16803 14.4 94
Protein Wnt-5a WNT5A Tbio Non-IDG -2.73149 587.4 277