Development Level

Tbio 82 | 10,625
Tchem 28 | 1,890
Tclin 12 | 602
Tdark 1 | 7,003

IMPC Phenotype

abnormal behavior 3 | 226
abnormal femur morphology 3 | 14
abnormal lens morphology 3 | 73
decreased hemoglobin content 3 | 53
decreased total body fat amoun... 3 | 186
increased hematocrit 3 | 36
preweaning lethality, complete... 3 | 633
abnormal coat-hair pigmentatio... 2 | 54
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
abnormal ear morphology 1 | 5
abnormal eye morphology 1 | 38
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
abnormal tail morphology 1 | 17
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
cataract 1 | 26
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
dilated heart left ventricle 1 | 10
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
herniated abdominal wall 1 | 4
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased vertical activity 1 | 18
irregularly shaped pupil 1 | 7
mydriasis 1 | 9
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 79 | 8,491
glioblastoma 73 | 5,572
osteosarcoma 71 | 7,933
pilocytic astrocytoma 63 | 3,086
psoriasis 61 | 6,685
Carcinoma 56 | 2,147
lung cancer 56 | 4,473
Cancer 55 | 2,346
medulloblastoma, large-cell 55 | 6,234
Breast cancer 48 | 3,098
atypical teratoid / rhabdoid tumor 46 | 4,369
invasive ductal carcinoma 46 | 2,950
pediatric high grade glioma 46 | 2,712
non-small cell lung cancer 44 | 2,798
pancreatic cancer 43 | 2,300
ulcerative colitis 41 | 2,087
interstitial cystitis 39 | 2,299
primary pancreatic ductal adenocarcinoma 39 | 1,271
malignant mesothelioma 38 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
lung adenocarcinoma 36 | 2,714
lung carcinoma 35 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,289
oligodendroglioma 33 | 2,849
pituitary cancer 32 | 1,972
cystic fibrosis 31 | 1,670
ependymoma 31 | 2,514
primitive neuroectodermal tumor 31 | 3,031
subependymal giant cell astrocytoma 29 | 2,287
ductal carcinoma in situ 28 | 1,745
Duchenne muscular dystrophy 27 | 602
group 4 medulloblastoma 25 | 1,875
juvenile dermatomyositis 25 | 1,189
posterior fossa group A ependymoma 25 | 1,511
gastric carcinoma 24 | 832
nasopharyngeal carcinoma 23 | 1,056
sonic hedgehog group medulloblastoma 23 | 1,482
tuberculosis 23 | 1,563
astrocytoma 22 | 1,493
breast carcinoma 22 | 1,614
diabetes mellitus 22 | 1,663
adrenocortical carcinoma 21 | 1,427
astrocytic glioma 20 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 499
colon cancer 20 | 1,475
cutaneous lupus erythematosus 20 | 1,056
Pick disease 19 | 1,893
adult high grade glioma 19 | 2,148
dermatomyositis 16 | 966
group 3 medulloblastoma 16 | 2,254
primary Sjogren syndrome 16 | 788
urothelial carcinoma 16 | 318
Becker muscular dystrophy 15 | 187
Kidney disease 15 | 397
Rheumatoid Arthritis 15 | 1,170
esophageal adenocarcinoma 15 | 737
Down syndrome 14 | 548
acute quadriplegic myopathy 13 | 1,157
interstitial lung disease 13 | 292
limb girdle muscular dystrophy 2A 13 | 156
Vascular disease 12 | 281
Intellectual disability 11 | 573
Osteoarthritis 11 | 96
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Atopic dermatitis 10 | 944
Ehlers-Danlos syndrome 10 | 42
IGA Glomerulonephritis 10 | 454
Multiple myeloma 10 | 1,327
Neoplasm Invasiveness 10 | 127
Spontaneous abortion 10 | 108
fibroadenoma 10 | 557
head and neck cancer and chronic obstructive pulmonary disease 10 | 237
medulloblastoma 10 | 1,524
non-small cell lung carcinoma 10 | 413
pterygium 10 | 74
spina bifida 10 | 1,064
Arthritis 9 | 248
Atherosclerosis 9 | 275
Stomach Neoplasms 9 | 282
active Crohn's disease 9 | 918
atypical teratoid/rhabdoid tumor 9 | 1,095
Noonan Syndrome 8 | 33
Osteoporosis 8 | 259
glioblastoma multiforme 8 | 347
head and neck cancer 8 | 270
posterior fossa group B ependymoma 8 | 1,530
progressive supranuclear palsy 8 | 674
Amyotrophic Lateral Sclerosis 7 | 432
Endometriosis 7 | 535
Heart disease 7 | 279
Hydrolethalus syndrome 7 | 128
Mammary Neoplasms 7 | 410
Multiple Sclerosis 7 | 498
Myopia 7 | 99
Neoplasm Metastasis 7 | 138
aldosterone-producing adenoma 7 | 664
mucosa-associated lymphoid tissue lymphoma 7 | 480
nephrosclerosis 7 | 329
periodontitis 7 | 269

Tissue

Cardiovascular System 123 | 17,957
Endocrine System 123 | 18,511
Female tissues 123 | 18,646
Liver and Pancreas 123 | 18,135
Male tissues 123 | 17,968
Nervous System 123 | 18,560
Urinary Tract 123 | 18,443
Blood and immune system 122 | 17,994
Digestive Tract 122 | 18,472
Respiratory system 122 | 17,483
Skin and soft tissues 122 | 18,114

Target Family

Non-IDG 105 | 11,969
Enzyme 9 | 4,146
Kinase 9 | 634

PathwayCommons: inoh Pathway

Integrin signaling pathway ( I... 123 | 123
Drosophila Toll-like receptor ... 235 | 235
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
TGF beta receptor complex degr... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
Inositol phosphate metabolism ... 42 | 42
TGF beta receptor I degradatio... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 37 | 37
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Collagen alpha-1(VIII) chain COL8A1 Tbio Non-IDG -1.25305 16.3 98
Collagen alpha-1(I) chain COL1A1 Tbio Non-IDG -2.94271 807.7 451
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Collagen alpha-1(IV) chain COL4A1 Tchem Non-IDG -2.25341 170.3 323
Collagen alpha-1(III) chain COL3A1 Tchem Non-IDG -2.54818 328.8 384
Elastin ELN Tbio Non-IDG -3.33458 2025.2 244
Proto-oncogene vav VAV1 Tchem Non-IDG -2.64007 465.9 479
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312