Development Level

Tbio 148 | 10,625
Tchem 51 | 1,890
Tclin 19 | 602
Tdark 5 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 14 | 633
decreased body weight 4 | 174
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
decreased bone mineral content 3 | 157
hydrops fetalis 3 | 22
impaired pupillary reflex 3 | 14
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased heart weight 3 | 37
increased mean corpuscular vol... 3 | 91
increased monocyte cell number 3 | 27
limb grasping 3 | 35
preweaning lethality, incomple... 3 | 260
abnormal kidney morphology 2 | 30
cataract 2 | 26
decreased NK T cell number 2 | 28
decreased circulating alanine ... 2 | 53
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased kidney weight 2 | 7
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
decreased startle reflex 2 | 48
impaired glucose tolerance 2 | 52
impaired righting response 2 | 19
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased lymphocyte cell numb... 2 | 9
increased startle reflex 2 | 38
mydriasis 2 | 9
short tibia 2 | 82
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal heart morphology 1 | 51
abnormal motor learning 1 | 4
abnormal pericardium morpholog... 1 | 11
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
absent startle reflex 1 | 15
cleft palate 1 | 6
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating thyroxin... 1 | 5
decreased circulating triglyce... 1 | 83
decreased coping response 1 | 5
decreased dendritic cell numbe... 1 | 3
decreased eosinophil cell numb... 1 | 41
decreased monocyte cell number 1 | 28
decreased spleen weight 1 | 13
enlarged kidney 1 | 7
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
hyperactivity 1 | 108
increased KLRG1-positive gamma... 1 | 2
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased effector memory T-he... 1 | 5
increased eosinophil cell numb... 1 | 9
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate variabili... 1 | 4
increased myeloid cell number 1 | 2
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased thoracic vertebrae n... 1 | 8
increased total body fat amoun... 1 | 57
microphthalmia 1 | 15
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
vertebral fusion 1 | 23

Disease

Cancer 113 | 2,346
psoriasis 101 | 6,685
lung cancer 64 | 4,466
osteosarcoma 61 | 7,933
ovarian cancer 59 | 8,484
diabetes mellitus 57 | 1,663
glioblastoma 57 | 5,572
medulloblastoma, large-cell 53 | 6,234
malignant mesothelioma 48 | 3,162
pilocytic astrocytoma 46 | 3,086
lung carcinoma 45 | 2,844
interstitial cystitis 44 | 2,299
Breast cancer 42 | 3,094
atypical teratoid / rhabdoid tumor 42 | 4,369
Asthma 41 | 349
Obesity 41 | 616
Kidney disease 39 | 396
cystic fibrosis 37 | 1,665
oligodendroglioma 37 | 2,849
ulcerative colitis 36 | 2,087
pituitary cancer 35 | 1,972
Schizophrenia 34 | 501
pediatric high grade glioma 33 | 2,712
lung adenocarcinoma 32 | 2,713
invasive ductal carcinoma 31 | 2,950
Hypertension 30 | 287
ependymoma 30 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
non-small cell lung cancer 30 | 2,798
tuberculosis 30 | 1,557
Arthritis 29 | 248
Autistic Disorder 28 | 320
Diarrhea 28 | 155
Heart disease 28 | 279
Mammary Neoplasms 28 | 410
colon cancer 28 | 1,475
Rheumatoid Arthritis 27 | 1,160
Hypersensitivity reaction type II disease 26 | 235
Inflammatory bowel disease 26 | 142
Multiple Sclerosis 26 | 498
group 3 medulloblastoma 26 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
pancreatic cancer 26 | 2,300
primitive neuroectodermal tumor 26 | 3,031
Cerebrovascular disease 25 | 231
Hypotension 25 | 53
Inflammation 25 | 109
Osteoporosis 25 | 257
Alzheimer's disease 24 | 644
Anemia 24 | 252
Atherosclerosis 24 | 275
Lung disease 24 | 132
Parkinson's disease 24 | 364
Pulmonary Fibrosis 24 | 66
posterior fossa group A ependymoma 24 | 1,511
Adenoma 23 | 165
Hypertensive disease 23 | 193
Allergic hypersensitivity disease 22 | 123
Endometriosis 22 | 535
Liver disease 22 | 219
Pain 22 | 70
cutaneous lupus erythematosus 22 | 1,056
Cleft palate 21 | 125
Coronary artery disease 21 | 240
Hypoglycemia 21 | 81
Prostatic Neoplasms 21 | 471
Seizures 21 | 95
breast carcinoma 21 | 1,614
ductal carcinoma in situ 21 | 1,745
Liver Cirrhosis, Experimental 20 | 108
Polycystic Ovary Syndrome 20 | 332
sonic hedgehog group medulloblastoma 20 | 1,482
Bipolar Disorder 19 | 266
Hyperalgesia 19 | 71
Infertility 19 | 163
Pancreatitis 19 | 97
astrocytic glioma 19 | 2,241
astrocytoma 19 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
Acromegaly 18 | 40
Dermatitis 18 | 107
Heart failure 18 | 80
Hypothyroidism 18 | 89
Neuropathy 18 | 210
adult high grade glioma 18 | 2,148
group 4 medulloblastoma 18 | 1,875
Allergic rhinitis 17 | 91
Carcinoma 17 | 2,147
Hyperglycemia 17 | 120
Reperfusion Injury 17 | 84
Spontaneous abortion 17 | 108
Cleft Lip 16 | 91
Eosinophilia 16 | 65
Hypogonadism 16 | 70
Influenza 16 | 142
Pneumonia 16 | 133
Vascular disease 16 | 281
subependymal giant cell astrocytoma 16 | 2,287
Myocardial Ischemia 15 | 169
fibroadenoma 15 | 557

Tissue

Nervous System 220 | 18,561
Female tissues 217 | 18,647
Digestive Tract 216 | 18,473
Skin and soft tissues 213 | 18,115
Endocrine System 212 | 18,512
Urinary Tract 212 | 18,444
Liver and Pancreas 205 | 18,136
Blood and immune system 202 | 17,995
Cardiovascular System 199 | 17,958
Respiratory system 194 | 17,484
Male tissues 191 | 17,969

Target Family

Non-IDG 191 | 11,971
GPCR 31 | 406
Enzyme 1 | 4,146

PathwayCommons: inoh Pathway

Heterotrimeric GTP-binding pro... 223 | 223
Drosophila Toll-like receptor ... 236 | 236
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
TGF beta receptor complex degr... 48 | 48
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
TGF beta receptor I degradatio... 43 | 43
Inositol phosphate metabolism ... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 38 | 38
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Delta-like protein 3 DLL3 Tbio Non-IDG -1.58510 42.7 181