Development Level

Tchem 18 | 1,890
Tbio 15 | 10,625
Tclin 10 | 602
Tdark 2 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 10 | 102
Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

abnormal bone structure 3 | 131
abnormal bone mineralization 2 | 55
decreased heart weight 2 | 44
decreased lean body mass 2 | 195
preweaning lethality, complete... 2 | 633
thrombocytopenia 2 | 46
abnormal embryo size 1 | 112
abnormal facial morphology 1 | 9
abnormal heart left ventricle ... 1 | 20
abnormal placenta vasculature 1 | 2
abnormal retinal pigmentation 1 | 61
cyanosis 1 | 6
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
edema 1 | 11
enlarged heart 1 | 111
hemorrhage 1 | 12
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased heart weight 1 | 37
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
male infertility 1 | 62
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260
respiratory system phenotype 1 | 2

Disease

medulloblastoma, large-cell 24 | 6,234
glioblastoma 23 | 5,572
atypical teratoid / rhabdoid tumor 21 | 4,369
primitive neuroectodermal tumor 21 | 3,031
osteosarcoma 18 | 7,933
ovarian cancer 17 | 8,491
pilocytic astrocytoma 17 | 3,086
psoriasis 17 | 6,685
oligodendroglioma 16 | 2,849
pediatric high grade glioma 15 | 2,712
Pick disease 14 | 1,893
ependymoma 14 | 2,514
lung carcinoma 12 | 2,844
Parkinson's disease 11 | 364
Schizophrenia 11 | 503
adult high grade glioma 10 | 2,148
Bipolar Disorder 9 | 266
Carcinoma 9 | 2,147
astrocytic glioma 9 | 2,241
medulloblastoma 9 | 1,524
subependymal giant cell astrocytoma 9 | 2,287
Epilepsy 8 | 346
Toxic encephalopathy 8 | 131
lung cancer 8 | 4,473
malignant mesothelioma 8 | 3,163
astrocytoma 7 | 1,493
Parkinsonism 6 | 19
Postencephalitic parkinsonism 6 | 12
colon cancer 6 | 1,475
group 3 medulloblastoma 6 | 2,254
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
invasive ductal carcinoma 6 | 2,950
posterior fossa group B ependymoma 6 | 1,530
ulcerative colitis 6 | 2,087
Alcoholism 5 | 14
Alzheimer's disease 5 | 644
Arteriosclerotic Parkinsonism 5 | 8
Autistic Disorder 5 | 320
Breast cancer 5 | 3,098
Cancer 5 | 2,346
Extrapyramidal disease 5 | 8
General anesthesia 5 | 53
Influenza A Prevention 5 | 7
Influenza due to Influenza A virus 5 | 7
Intellectual disability 5 | 573
Local anesthesia 5 | 40
Obesity 5 | 616
breast carcinoma 5 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
pituitary cancer 5 | 1,972
Alcohol dependence 4 | 107
Angina pectoris 4 | 21
Huntington's disease 4 | 72
Hypertensive disease 4 | 193
Hypertensive disorder 4 | 58
Malignant hyperthermia 4 | 25
Prinzmetal angina 4 | 6
Rheumatoid Arthritis 4 | 1,170
Type 2 diabetes mellitus 4 | 192
ductal carcinoma in situ 4 | 1,745
non-small cell lung cancer 4 | 2,798
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482
Atopic dermatitis 3 | 944
Atrial Fibrillation 3 | 110
Brugada Syndrome (disorder) 3 | 15
Brugada syndrome 3 | 26
Carney complex 3 | 23
Cerebrovascular disease 3 | 231
Cocaine-Related Disorders 3 | 88
Dementia 3 | 129
High pressure neurological syndrome 3 | 9
Major Depressive Disorder 3 | 106
Moderate to Severe Alzheimer's Type Dementia 3 | 5
Opiate dependence 3 | 12
Short QT syndrome 3 | 12
Subarachnoid intracranial hemorrhage 3 | 3
Substance Withdrawal Syndrome 3 | 55
Substance abuse 3 | 55
Timothy syndrome 3 | 12
Waldenstrons macroglobulinemia 3 | 764
cutaneous lupus erythematosus 3 | 1,056
diabetes mellitus 3 | 1,663
gastric carcinoma 3 | 832
interstitial cystitis 3 | 2,299
pancreatic cancer 3 | 2,300
Acromegaly 2 | 40
Adenoma 2 | 165
Cushing's syndrome 2 | 47
Disease Progression 2 | 125
Essential Hypertension 2 | 82
Hypertension 2 | 293
Seizures 2 | 95
Stomach Neoplasms 2 | 282
dermatomyositis 2 | 966
lung adenocarcinoma 2 | 2,714
spina bifida 2 | 1,064
tuberculosis 2 | 1,563

Tissue

Cardiovascular System 44 | 17,957
Digestive Tract 44 | 18,472
Endocrine System 44 | 18,511
Female tissues 44 | 18,646
Liver and Pancreas 44 | 18,135
Nervous System 44 | 18,560
Urinary Tract 44 | 18,443
Skin and soft tissues 43 | 18,114
Blood and immune system 42 | 17,994
Male tissues 42 | 17,968
Respiratory system 42 | 17,483

Target Family

Ion Channel 21 | 341
Enzyme 13 | 4,146
Kinase 4 | 634
Non-IDG 4 | 11,969
GPCR 2 | 408
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

Heterotrimeric GPCR signaling ... 45 | 45
Drosophila Toll-like receptor ... 235 | 235
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
TGF beta receptor complex degr... 47 | 47
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
Inositol phosphate metabolism ... 42 | 42
TGF beta receptor I degradatio... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 37 | 37
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

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