Development Level

Tbio 45 | 10,625
Tchem 11 | 1,890

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal bone mineralization 2 | 55
abnormal lens morphology 2 | 73
enlarged heart 2 | 111
hydrops fetalis 2 | 22
increased mean corpuscular vol... 2 | 91
short tibia 2 | 82
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased cellular hemoglobin ... 1 | 2
increased circulating alkaline... 1 | 119
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
kinked tail 1 | 3
mydriasis 1 | 9
preweaning lethality, incomple... 1 | 260
syndactyly 1 | 4
thrombocytosis 1 | 23

Disease

psoriasis 35 | 6,685
ovarian cancer 29 | 8,484
Cancer 28 | 2,346
glioblastoma 25 | 5,572
medulloblastoma, large-cell 23 | 6,234
atypical teratoid / rhabdoid tumor 22 | 4,369
osteosarcoma 22 | 7,933
pilocytic astrocytoma 19 | 3,086
Breast cancer 18 | 3,094
interstitial cystitis 16 | 2,299
invasive ductal carcinoma 16 | 2,950
lung cancer 16 | 4,466
pancreatic cancer 16 | 2,300
lung adenocarcinoma 15 | 2,713
non-small cell lung cancer 15 | 2,798
pediatric high grade glioma 14 | 2,712
sonic hedgehog group medulloblastoma 14 | 1,482
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
oligodendroglioma 13 | 2,849
primary pancreatic ductal adenocarcinoma 13 | 1,271
primitive neuroectodermal tumor 13 | 3,031
ductal carcinoma in situ 12 | 1,745
astrocytic glioma 11 | 2,241
breast carcinoma 11 | 1,614
cutaneous lupus erythematosus 11 | 1,056
ependymoma 11 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
lung carcinoma 11 | 2,844
malignant mesothelioma 11 | 3,162
Osteoporosis 10 | 257
cystic fibrosis 10 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
pituitary cancer 10 | 1,972
Duchenne muscular dystrophy 9 | 602
adrenocortical carcinoma 9 | 1,427
diabetes mellitus 9 | 1,663
juvenile dermatomyositis 9 | 1,189
posterior fossa group A ependymoma 9 | 1,511
adult high grade glioma 8 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
dermatomyositis 8 | 933
group 4 medulloblastoma 8 | 1,875
Pick disease 7 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
ulcerative colitis 7 | 2,087
Atopic dermatitis 6 | 944
Carcinoma 6 | 2,147
acute quadriplegic myopathy 6 | 1,157
astrocytoma 6 | 1,493
colon cancer 6 | 1,475
gastric carcinoma 6 | 832
non primary Sjogren syndrome sicca 6 | 840
posterior fossa group B ependymoma 6 | 1,530
subependymal giant cell astrocytoma 6 | 2,287
Colorectal Neoplasms 5 | 217
Multiple myeloma 5 | 1,327
Obesity 5 | 616
Parkinson's disease 5 | 364
Peripheral Neuropathy 5 | 303
Rheumatoid Arthritis 5 | 1,160
esophageal adenocarcinoma 5 | 737
tuberculosis 5 | 1,557
Cleft palate 4 | 125
IGA Glomerulonephritis 4 | 454
Kidney disease 4 | 396
Mammary Neoplasms 4 | 410
chronic rhinosinusitis 4 | 512
fascioscapulohumeral muscular dystrophy 4 | 100
group 3 medulloblastoma 4 | 2,254
medulloblastoma 4 | 1,524
nephrosclerosis 4 | 329
non diabetic and post-ischemic heart failure 4 | 200
sarcoidosis 4 | 358
Adenoma 3 | 165
Amyotrophic Lateral Sclerosis 3 | 431
Arthritis 3 | 248
Cleft Lip 3 | 91
Colonic Neoplasms 3 | 126
Craniofacial Abnormalities 3 | 147
Crohn's disease 3 | 304
Down syndrome 3 | 548
Endometriosis 3 | 535
Female Urogenital Diseases 3 | 18
Heart conduction disease 3 | 65
Hyperostosis 3 | 16
Hypersensitivity reaction type II disease 3 | 235
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 3 | 12
Prostatic Neoplasms 3 | 471
Uterine Cervical Neoplasm 3 | 21
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 780
atypical teratoid/rhabdoid tumor 3 | 1,095
facioscapulohumeral dystrophy 3 | 286
fibroadenoma 3 | 557
inflammatory breast cancer 3 | 404
limb girdle muscular dystrophy 2A 3 | 156
primary Sjogren syndrome 3 | 789
spina bifida 3 | 1,064
urothelial carcinoma 3 | 318

Tissue

Digestive Tract 56 | 18,473
Endocrine System 56 | 18,512
Female tissues 56 | 18,647
Male tissues 56 | 17,969
Nervous System 56 | 18,561
Respiratory system 56 | 17,484
Skin and soft tissues 56 | 18,115
Urinary Tract 56 | 18,444
Blood and immune system 55 | 17,995
Liver and Pancreas 55 | 18,136
Cardiovascular System 54 | 17,958

Target Family

Non-IDG 49 | 11,971
Transcription Factor 4 | 1,400
Kinase 2 | 634
Enzyme 1 | 4,146

PathwayCommons: inoh Pathway

Canonical Wnt signaling pathwa... 56 | 56
Drosophila Toll-like receptor ... 236 | 236
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
TGF beta receptor complex degr... 48 | 48
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
TGF beta receptor I degradatio... 43 | 43
Inositol phosphate metabolism ... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 38 | 38
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.06756 1202.0 278
Glypican-1 GPC1 Tbio Non-IDG -2.34418 224.6 160
Syndecan-3 SDC3 Tbio Non-IDG -1.81072 73.3 153
Kremen protein 2 KREMEN2 Tbio Non-IDG -0.72771 5.50 84
Dickkopf-related protein 1 DKK1 Tchem Non-IDG -2.70833 552.4 624
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.56120 352.4 554
Protein Wnt-6 WNT6 Tbio Non-IDG -1.60144 43.1 156
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.35945 217.4 316
14-3-3 protein epsilon YWHAE Tchem Non-IDG -2.18406 158.6 309
Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 Tbio Enzyme -3.00888 1109.0 163