Development Level

Tchem 115 | 1,890
Tclin 34 | 602
Tbio 23 | 10,625
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 13 | 134

IMPC Term

preweaning lethality, complete... 14 | 633
preweaning lethality, incomple... 8 | 260
decreased bone mineral content 5 | 157
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
abnormal bone structure 4 | 131
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
abnormal lens morphology 3 | 73
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
enlarged heart 3 | 111
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
anophthalmia 2 | 20
decreased blood urea nitrogen ... 2 | 31
decreased circulating choleste... 2 | 85
decreased circulating iron lev... 2 | 25
decreased fasted circulating g... 2 | 49
enlarged spleen 2 | 26
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating LDL chol... 2 | 15
increased circulating iron lev... 2 | 25
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased or absent threshold ... 2 | 128
male infertility 2 | 62
microphthalmia 2 | 15
small superior vagus ganglion 2 | 20
small testis 2 | 37
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
absent vibrissae 1 | 14
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased NK cell number 1 | 19
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 16
increased effector memory T-he... 1 | 5
increased eosinophil cell numb... 1 | 9
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 36
increased mean platelet volume 1 | 19
increased memory-marker gamma-... 1 | 2
increased prepulse inhibition 1 | 21
increased red blood cell distr... 1 | 21
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
short tibia 1 | 82
small adrenal glands 1 | 15
thrombocytosis 1 | 23
tremors 1 | 34

Disease

osteosarcoma 107 | 7,933
ovarian cancer 103 | 8,484
medulloblastoma, large-cell 88 | 6,234
glioblastoma 86 | 5,572
Cancer 85 | 2,346
psoriasis 78 | 6,685
atypical teratoid / rhabdoid tumor 65 | 4,369
lung cancer 60 | 4,466
pilocytic astrocytoma 53 | 3,086
malignant mesothelioma 49 | 3,162
ependymoma 45 | 2,514
oligodendroglioma 45 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
non-small cell lung cancer 44 | 2,798
primitive neuroectodermal tumor 44 | 3,031
Carcinoma 43 | 2,147
Breast cancer 42 | 3,094
pediatric high grade glioma 37 | 2,712
lung carcinoma 36 | 2,844
invasive ductal carcinoma 35 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
adult high grade glioma 32 | 2,148
ulcerative colitis 32 | 2,087
subependymal giant cell astrocytoma 31 | 2,287
astrocytoma 30 | 1,493
lung adenocarcinoma 29 | 2,713
tuberculosis 29 | 1,557
group 4 medulloblastoma 28 | 1,875
Pick disease 27 | 1,893
astrocytic glioma 27 | 2,241
interstitial cystitis 27 | 2,299
adrenocortical carcinoma 25 | 1,427
medulloblastoma 25 | 1,524
pancreatic cancer 24 | 2,300
Rheumatoid Arthritis 23 | 1,160
group 3 medulloblastoma 23 | 2,254
Renal Cell Carcinoma 22 | 199
pituitary cancer 22 | 1,972
breast carcinoma 21 | 1,614
cystic fibrosis 21 | 1,665
diabetes mellitus 21 | 1,663
colon cancer 20 | 1,475
Mammary Neoplasms 18 | 410
ductal carcinoma in situ 18 | 1,745
sonic hedgehog group medulloblastoma 18 | 1,482
Alzheimer's disease 17 | 644
Vascular disease 16 | 281
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
posterior fossa group A ependymoma 16 | 1,511
Hamman-Rich syndrome 15 | 35
Obesity 15 | 616
Prostatic Neoplasms 15 | 471
primary pancreatic ductal adenocarcinoma 15 | 1,271
spina bifida 15 | 1,064
Lung Neoplasms 14 | 171
Schizophrenia 14 | 501
acute myeloid leukemia 14 | 780
posterior fossa group B ependymoma 14 | 1,530
Blastic phase chronic myeloid leukemia 13 | 58
Chronic Myelocytic Leukemia Accelerated Phase 13 | 59
Parkinson's disease 13 | 364
Waldenstrons macroglobulinemia 13 | 765
acute quadriplegic myopathy 13 | 1,157
atypical teratoid/rhabdoid tumor 13 | 1,095
juvenile dermatomyositis 13 | 1,189
non-small cell lung carcinoma 13 | 413
primary Sjogren syndrome 13 | 789
Gastrointestinal stromal tumor 12 | 61
cutaneous lupus erythematosus 12 | 1,056
Intellectual disability 11 | 573
Multiple myeloma 11 | 1,327
Pancreatic Neuroendocrine Tumor 11 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 11 | 47
Stomach Neoplasms 11 | 282
Carcinoma of thyroid 10 | 17
Cardiomyopathies 10 | 90
Chronic phase chronic myeloid leukemia 10 | 45
Heart disease 10 | 279
Melanoma 10 | 261
Papillary thyroid carcinoma 10 | 37
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 10 | 45
Sarcoma of soft tissue 10 | 11
Arthritis 9 | 248
Asthma 9 | 349
Atopic dermatitis 9 | 944
Bipolar Disorder 9 | 266
Craniofacial Abnormalities 9 | 147
Hyperalgesia 9 | 71
Neoplasm Metastasis 9 | 138
Toxic encephalopathy 9 | 131
dermatomyositis 9 | 933
esophageal adenocarcinoma 9 | 737
nasopharyngeal carcinoma 9 | 1,056
Gout 8 | 93
Kidney disease 8 | 396
Peripheral Neuropathy 8 | 303
active Crohn's disease 8 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
non primary Sjogren syndrome sicca 8 | 840

Tissue

Blood and immune system 173 | 17,995
Female tissues 173 | 18,647
Liver and Pancreas 173 | 18,136
Nervous System 173 | 18,561
Cardiovascular System 172 | 17,958
Digestive Tract 172 | 18,473
Endocrine System 172 | 18,512
Male tissues 172 | 17,969
Urinary Tract 172 | 18,444
Respiratory system 171 | 17,484
Skin and soft tissues 170 | 18,115

Target Family

Kinase 160 | 634
Enzyme 8 | 4,146
Non-IDG 5 | 11,971

PathwayCommons: inoh Pathway

AKT(PKB)-Bad signaling ( IL-7 ... 173 | 173
Drosophila Toll-like receptor ... 236 | 236
Heterotrimeric GPCR signaling ... 235 | 235
Heterotrimeric GPCR signaling ... 233 | 233
Heterotrimeric GPCR signaling ... 224 | 224
Heterotrimeric GTP-binding pro... 224 | 224
Heterotrimeric GPCR signaling ... 223 | 223
Heterotrimeric GTP-binding pro... 223 | 223
VEGF signaling pathway ( VEGF ... 183 | 183
Positive regulation of (Transc... 178 | 178
AKT(PKB)-Bad signaling ( EPO s... 173 | 173
Integrin signaling pathway ( I... 123 | 123
JAK-STAT pathway and regulatio... 96 | 96
Purine nucleotides and Nucleos... 85 | 85
B cell receptor signaling path... 60 | 60
Tryptophan degradation ( Trypt... 60 | 60
Insulin receptor signaling (Ma... 58 | 58
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Canonical Wnt signaling pathwa... 56 | 56
Insulin receptor signaling ( I... 55 | 55
TGF-beta_super_family_signalin... 51 | 51
Mammalian Wnt signaling pathwa... 49 | 49
TGF beta receptor complex degr... 48 | 48
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Canonical)... 47 | 47
Signaling with Wnt (Mammal) ( ... 47 | 47
Heterotrimeric GPCR signaling ... 45 | 45
FGF signaling pathway ( FGF si... 44 | 44
T cell receptor signaling path... 43 | 43
TGF beta receptor I degradatio... 43 | 43
Inositol phosphate metabolism ... 42 | 42
CD4 T cell receptor signaling ... 40 | 40
Cytokine receptor degradation ... 40 | 40
Negative regulation of (Phosph... 40 | 40
T cell receptor signaling (PLC... 40 | 40
SnoN degradation signaling ( T... 38 | 38
T cell receptor signaling (PLC... 37 | 37
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha i GDP-GTP exchange sig... 36 | 36
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
G alpha s GDP-GTP exchange sig... 35 | 35
BMP signaling pathway ( TGF-be... 34 | 34
HGF signaling pathway ( HGF si... 30 | 30
Pyrimidine Nucleotides and Nuc... 30 | 30
Arginine and Proline metabolis... 29 | 29
PDGF signaling pathway (Mammal... 29 | 29
Xenopus axis formation Wnt sig... 28 | 28
Glycine and Serine metabolism ... 27 | 27
IGF1 signaling pathway ( IGF1 ... 27 | 27
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Stabilization and accumulation... 24 | 24
Prostaglandin and Leukotriene ... 22 | 22
Fas signaling pathway ( Fas si... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (G alph... 21 | 21
Negative regulation of (transc... 21 | 21
FGF8 signaling pathway(Mouse) ... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of (G alph... 20 | 20
Negative regulation of heterot... 20 | 20
Canonical Notch signaling path... 19 | 19
IFN alpha signaling pathway((J... 19 | 19
Signaling with Wnt (Xenopus) (... 19 | 19
Toll-like receptor signaling p... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Canonic... 19 | 19
Wnt secretory pathway (Mammal)... 19 | 19
FGF8 signaling pathway(Xenopus... 18 | 18
Heterotrimeric GPCR signaling ... 18 | 18
Histidine degradation ( Histid... 18 | 18
IFN alpha signaling pathway(JA... 18 | 18
Nicotinate and Nicotinamide me... 18 | 18
PKA activation signaling ( GPC... 18 | 18
PKA activation signaling ( GPC... 18 | 18
Ci/Gli processing signaling ( ... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
ERK cascade ( FGF8 signaling (... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
IFN alpha signaling pathway(JA... 17 | 17
Folate metabolism ( Folate met... 16 | 16
JNK cascade ( IL-1 signaling p... 16 | 16
Methionine and Cysteine metabo... 16 | 16
NGF signaling pathway ( NGF si... 16 | 16
Valine,Leucine and Isoleucine ... 16 | 16
p38 cascade ( IL-1 signaling p... 16 | 16
IL-1_signaling(through_IKK-NFk... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.59340 415.3 337
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.28652 191.1 505
Cyclin-H CCNH Tbio Non-IDG -1.98840 89.8 354
CDK-activating kinase assembly factor MAT1 MNAT1 Tbio Enzyme -2.07687 125.7 152