Development Level

Tbio 37 | 10,625
Tchem 9 | 1,890

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal kidney morphology 2 | 30
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal heart left ventricle ... 1 | 20
decreased IgM level 1 | 1
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased lean body mass 1 | 195
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 30 | 8,484
psoriasis 21 | 6,685
Multiple myeloma 16 | 1,327
lung cancer 16 | 4,466
glioblastoma 15 | 5,572
osteosarcoma 15 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
astrocytic glioma 13 | 2,241
medulloblastoma, large-cell 13 | 6,234
pancreatic cancer 12 | 2,300
malignant mesothelioma 11 | 3,162
non-small cell lung cancer 11 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
lung adenocarcinoma 10 | 2,713
Cancer 9 | 2,346
Pick disease 9 | 1,893
atypical teratoid / rhabdoid tumor 8 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
Breast cancer 7 | 3,094
Waldenstrons macroglobulinemia 7 | 765
dermatomyositis 7 | 933
ependymoma 7 | 2,514
Congenital hemolytic anemia 6 | 30
Glycogen storage disease 6 | 37
Leigh disease 6 | 81
Myocardial Ischemia 6 | 169
Obesity 6 | 616
Stomach Neoplasms 6 | 282
acute quadriplegic myopathy 6 | 1,157
adrenocortical carcinoma 6 | 1,427
adult high grade glioma 6 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
invasive ductal carcinoma 6 | 2,950
medulloblastoma 6 | 1,524
oligodendroglioma 6 | 2,849
primary pancreatic ductal adenocarcinoma 6 | 1,271
primitive neuroectodermal tumor 6 | 3,031
Alzheimer's disease 5 | 644
Degenerative polyarthritis 5 | 93
Lactic acidosis 5 | 42
Liver carcinoma 5 | 217
Neoplastic Syndromes, Hereditary 5 | 48
Osteoporosis 5 | 257
atypical teratoid/rhabdoid tumor 5 | 1,095
group 3 medulloblastoma 5 | 2,254
group 4 medulloblastoma 5 | 1,875
pilocytic astrocytoma 5 | 3,086
ulcerative colitis 5 | 2,087
Animal Mammary Neoplasms 4 | 136
Diabetes Mellitus, Experimental 4 | 106
Gastrointestinal stromal tumor 4 | 61
Hemangioma 4 | 35
Mammary Neoplasms, Experimental 4 | 150
Mouth Neoplasms 4 | 42
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
Squamous cell carcinoma 4 | 94
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
lung carcinoma 4 | 2,844
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 1,511
Anoxia 3 | 33
Carney Triad 3 | 3
Disease Progression 3 | 125
Drug-Induced Liver Injury 3 | 118
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Mammary Neoplasms 3 | 410
Methylmalonic acidemia 3 | 39
Mitochondrial complex II deficiency 3 | 5
Neoplasm Invasiveness 3 | 127
Neurodegenerative disease 3 | 383
Neurofibromatosis 3 | 37
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA 3 | 3
Paraganglioma 3 | 12
Pyruvate decarboxylase deficiency 3 | 15
Renal Cell Carcinoma 3 | 199
Sideroblastic anemia with spinocerebellar ataxia 3 | 6
aldosterone-producing adenoma 3 | 664
breast carcinoma 3 | 1,614
cystic fibrosis 3 | 1,665
diabetes mellitus 3 | 1,663
extra-adrenal pheochromocytoma 3 | 7
hereditary spastic paraplegia 3 | 313
mucosa-associated lymphoid tissue lymphoma 3 | 480
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung carcinoma 3 | 413
pediatric high grade glioma 3 | 2,712
subependymal giant cell astrocytoma 3 | 2,287
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Down syndrome 2 | 548
Duchenne muscular dystrophy 2 | 602
Male infertility 2 | 170
Type 2 diabetes mellitus 2 | 189
active Crohn's disease 2 | 918
acute myeloid leukemia 2 | 780
astrocytoma 2 | 1,493
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis 2 | 1,557

Tissue

Blood and immune system 46 | 17,995
Cardiovascular System 46 | 17,958
Digestive Tract 46 | 18,473
Endocrine System 46 | 18,512
Female tissues 46 | 18,647
Liver and Pancreas 46 | 18,136
Male tissues 46 | 17,969
Nervous System 46 | 18,561
Respiratory system 46 | 17,484
Urinary Tract 46 | 18,444
Skin and soft tissues 45 | 18,115

Target Family

Enzyme 35 | 4,146
Kinase 11 | 634

PathwayCommons: humancyc Pathway

superpathway of conversion of ... 46 | 46
superpathway of inositol phosp... 68 | 68
purine nucleotides de novo bio... 43 | 43
superpathway of purine nucleot... 43 | 43
tRNA charging 38 | 38
phospholipases 37 | 37
mucin core 1 and core 2 O-glyc... 28 | 28
3-phosphoinositide biosynthesi... 27 | 27
triacylglycerol biosynthesis 27 | 27
D-myo-inositol (1,4,5)-trispho... 25 | 25
superpathway of cholesterol bi... 25 | 25
gluconeogenesis 24 | 24
glycolysis 24 | 24
adenosine ribonucleotides de n... 23 | 23
CDP-diacylglycerol biosynthesi... 22 | 22
glutathione-mediated detoxific... 22 | 22
superpathway of pyrimidine deo... 21 | 21
3-phosphoinositide degradation 20 | 20
superpathway of D-myo-inositol... 20 | 20
D-myo-inositol-5-phosphate met... 19 | 19
retinol biosynthesis 18 | 18
TCA cycle 17 | 17
superpathway of methionine deg... 17 | 17
fatty acid β-oxidation 16 | 16
superpathway of pyrimidine deo... 16 | 16
the visual cycle I (vertebrate... 16 | 16
1D-myo-inositol hexakisphospha... 15 | 15
D-myo-inositol (1,3,4)-trispho... 15 | 15
fatty acid β-oxidation (p... 15 | 15
guanosine nucleotides de novo ... 15 | 15
pyrimidine deoxyribonucleotide... 15 | 15
pyrimidine deoxyribonucleotide... 15 | 15
γ-linolenate biosynthesi... 14 | 14
bile acid biosynthesis, neutra... 14 | 14
superpathway of pyrimidine rib... 14 | 14
triacylglycerol degradation 14 | 14
D-myo-inositol (1,4,5)-trispho... 13 | 13
L-kynurenine degradation 13 | 13
cholesterol biosynthesis I 13 | 13
cholesterol biosynthesis II (v... 13 | 13
cholesterol biosynthesis III (... 13 | 13
icosapentaenoate biosynthesis ... 13 | 13
stearate biosynthesis 13 | 13
valine degradation 13 | 13
NAD de novo biosynthesis 12 | 12
UTP and CTP de novo biosynthes... 12 | 12
guanosine ribonucleotides de n... 12 | 12
isoleucine degradation 12 | 12
leucine degradation 12 | 12
purine deoxyribonucleosides sa... 12 | 12
superpathway of geranylgeranyl... 12 | 12
adenosine deoxyribonucleotides... 11 | 11
guanosine deoxyribonucleotides... 11 | 11
pyrimidine deoxyribonucleotide... 11 | 11
reactive oxygen species degrad... 11 | 11
CMP phosphorylation 10 | 10
mevalonate pathway 10 | 10
noradrenaline and adrenaline d... 10 | 10
purine nucleotides degradation 10 | 10
putrescine degradation III 10 | 10
terminal O-glycans residues mo... 10 | 10
C20 prostanoid biosynthesis 9 | 9
UDP-N-acetyl-D-galactosamine b... 9 | 9
dolichyl-diphosphooligosacchar... 9 | 9
glycogenolysis 9 | 9
heme biosynthesis 9 | 9
methionine salvage cycle III 9 | 9
serotonin degradation 9 | 9
sphingosine and sphingosine-1-... 9 | 9
tryptophan degradation 9 | 9
2-oxobutanoate degradation 8 | 8
chondroitin sulfate biosynthes... 8 | 8
fatty acid activation 8 | 8
retinoate biosynthesis I 8 | 8
sphingomyelin metabolism/ceram... 8 | 8
sucrose degradation 8 | 8
γ-glutamyl cycle 7 | 7
GABA shunt 7 | 7
adenosine nucleotides degradat... 7 | 7
androgen biosynthesis 7 | 7
ceramide de novo biosynthesis 7 | 7
chondroitin sulfate degradatio... 7 | 7
inositol pyrophosphates biosyn... 7 | 7
leukotriene biosynthesis 7 | 7
oxidative ethanol degradation ... 7 | 7
pentose phosphate pathway 7 | 7
serine and glycine biosynthesi... 7 | 7
superpathway of choline degrad... 7 | 7
thyroid hormone metabolism II ... 7 | 7
tryptophan degradation to 2-am... 7 | 7
ubiquinol-10 biosynthesis 7 | 7
2'-deoxy-α-D-ribose 1-ph... 6 | 6
GDP-mannose biosynthesis 6 | 6
cysteine biosynthesis 6 | 6
lysine degradation II (pipecol... 6 | 6
oleate biosynthesis 6 | 6
phosphatidylcholine biosynthes... 6 | 6
phosphatidylethanolamine biosy... 6 | 6
selenocysteine biosynthesis 6 | 6
zymosterol biosynthesis 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.77086 576.3 300
Beta-enolase ENO3 Tbio Enzyme -2.37121 235.8 236
ATP-dependent 6-phosphofructokinase, platelet type PFKP Tbio Kinase -1.89344 74.7 268
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G Tbio Enzyme -0.19018 0.67 161
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A Tbio Enzyme -1.40593 22.4 131
Hexokinase-2 HK2 Tchem Kinase -2.57126 391.1 373