Development Level

Tchem 7 | 1,598
Tbio 6 | 11,445

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46

Disease

ovarian cancer 9 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Carcinoma 7 | 11,493
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
Antley-Bixler syndrome 6 | 16
Smith-Lemli-Opitz syndrome 6 | 9
lung cancer 6 | 4,740
medulloblastoma, large-cell 6 | 6,241
Autosomal recessive predisposition 5 | 1,442
Cataract 5 | 297
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Pick disease 5 | 1,894
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
Breast cancer 4 | 3,578
Chondrodysplasia punctata 4 | 41
Congenital Epicanthus 4 | 177
Congenital ichthyosiform erythroderma 4 | 28
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Hypoplastic mandible condyle 4 | 275
Intellectual disability 4 | 1,016
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Pediatric failure to thrive 4 | 365
Seizures 4 | 596
Stippled epiphyses 4 | 28
active Crohn's disease 4 | 922
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
Anteverted nostril 3 | 191
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Congenital deafness 3 | 185
Deafness 3 | 198
Dull intelligence 3 | 645
Fibular polydactyly 3 | 12
Hearing Loss, Partial 3 | 185
Hydronephrosis 3 | 89
Hypotrophic malar bone 3 | 129
Ichthyosis 3 | 56
Lens Opacities 3 | 231
Low intelligence 3 | 645
Low set ears 3 | 181
Malar flattening 3 | 129
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Mevalonic aciduria 3 | 16
Muscle hypotonia 3 | 571
Nystagmus 3 | 317
Polyhydramnios 3 | 108
Poor school performance 3 | 645
Postaxial foot polydactyly 3 | 12
Small head 3 | 374
Strabismus 3 | 270
Ulnar polydactyly of fingers 3 | 47
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
glioblastoma 3 | 5,792
group 4 medulloblastoma 3 | 1,855
hearing impairment 3 | 199
pituitary cancer 3 | 1,972
Acquired scoliosis 2 | 281
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Atopic dermatitis 2 | 952
Cancer 2 | 2,499
Concave bridge of nose 2 | 195
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Gingival Hyperplasia 2 | 34
Gingival Hypertrophy 2 | 34
Gingival Overgrowth 2 | 36
Hepatomegaly 2 | 285
Long philtrum 2 | 137
Micromelia 2 | 58
Physical aggression 2 | 76
Posteriorly rotated ear 2 | 61
Short nose 2 | 132
Small nose 2 | 132
active ulcerative colitis 2 | 764
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
non-small cell lung cancer 2 | 2,890

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 12 | 4,145
Epigenetic 1 | 242

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lathosterol oxidase SC5D Tbio Enzyme -1.42233 28.3 26
Lanosterol synthase LSS Tchem Enzyme -2.22381 150.1 87
7-dehydrocholesterol reductase DHCR7 Tchem Enzyme -2.44252 276.5 109
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
Methylsterol monooxygenase 1 MSMO1 Tbio Enzyme -1.64987 43.8 106
Squalene monooxygenase SQLE Tchem Enzyme -1.89887 71.9 109
Lamin-B receptor LBR Tbio Epigenetic -3.02961 1057.1 134
Squalene synthase FDFT1 Tchem Enzyme -2.57966 374.3 291
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase EBP Tchem Enzyme -2.03266 104.2 137
Delta(24)-sterol reductase DHCR24 Tbio Enzyme -2.21293 167.3 181