Development Level

Tbio 4 | 11,445
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
cataract 1 | 92
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 6 | 11,493
ovarian cancer 5 | 8,520
osteosarcoma 4 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
adult high grade glioma 3 | 3,801
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
psoriasis 3 | 6,694
Breast cancer 2 | 3,578
Intellectual disability 2 | 1,016
Liver Cirrhosis, Experimental 2 | 769
adrenocortical carcinoma 2 | 1,428
ductal carcinoma in situ 2 | 1,745
glioblastoma 2 | 5,792
invasive ductal carcinoma 2 | 2,951
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
tuberculosis 2 | 2,010
Abnormal urinary amino-acid findings 1 | 38
Abruptio Placentae 1 | 3
Amelogenesis imperfecta type 1B 1 | 4
Amelogenesis imperfecta type 1E 1 | 3
Aminoaciduria 1 | 38
Amyotrophic lateral sclerosis 1 | 451
Anemia, Megaloblastic 1 | 16
Astrocytoma, Pilocytic 1 | 3,081
Ataxia 1 | 15
Atypical lipomatous tumor 1 | 2
Autoimmune hepatitis 1 | 11
Autosomal recessive predisposition 1 | 1,442
Bipolar Disorder 1 | 666
Burkitt Lymphoma 1 | 20
Cleft Lip 1 | 141
Cleft Palate 1 | 271
Congenital heart disease 1 | 93
Dull intelligence 1 | 645
Endometriosis 1 | 540
Glutamate formiminotransferase deficiency 1 | 1
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Histidinemia 1 | 9
Hodgkin Disease 1 | 15
Homocystinuria 1 | 21
Hyperhomocysteinemia 1 | 37
Hypersegmentation of neutrophil nuclei 1 | 1
Kernicterus 1 | 11
Low intelligence 1 | 645
Megaloblastic anemia 1 | 18
Mental Retardation 1 | 645
Mental deficiency 1 | 645
Methylmalonic acidemia 1 | 37
Neural Tube Defects 1 | 31
Neural tube defect, folate-sensitive 1 | 4
Neural tube defects, folate-sensitive 1 | 2
Orotic aciduria 1 | 18
Pelvic inflammatory disease 1 | 21
Polycystic ovary syndrome 1 | 360
Poor growth 1 | 114
Poor school performance 1 | 645
Positive ferric chloride test 1 | 1
Propionic acidemia 1 | 16
Schizophrenia 1 | 1,160
Sigmoid colon cancer 1 | 4
Specific language impairment 1 | 34
Very poor growth 1 | 114
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
acute quadriplegic myopathy 1 | 1,158
astrocytic glioma 1 | 2,597
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
beta-ketothiolase deficiency 1 | 13
breast carcinoma 1 | 1,638
colon cancer 1 | 1,478
cystic fibrosis 1 | 1,696
dermatomyositis 1 | 966
diabetes mellitus 1 | 1,728
esophageal adenocarcinoma 1 | 737
group 3 medulloblastoma 1 | 4,104
head and neck cancer 1 | 271
interstitial cystitis 1 | 2,312
interstitial lung disease 1 | 298
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
juvenile dermatomyositis 1 | 1,187
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
nasopharyngeal carcinoma 1 | 1,058
nephrosclerosis 1 | 333
neural tube defect 1 | 9
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
pancreatic carcinoma 1 | 562
primitive neuroectodermal tumor 1 | 3,035
spina bifida 1 | 1,074
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 7 | 16,909
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Nervous System 7 | 16,725
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Male tissues 6 | 17,142
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678
Respiratory system 5 | 16,393

Target Family

Enzyme 7 | 4,145

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Urocanate hydratase UROC1 Tbio Enzyme -1.01946 10.3 60
Probable imidazolonepropionase AMDHD1 Tdark Enzyme -0.17124 1.82 62
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.43089 24.9 131
Histidine ammonia-lyase HAL Tbio Enzyme -2.01531 102.1 85
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 MTHFD2L Tdark Enzyme -0.45230 2.70 114