Development Level

Tbio 19 | 11,445
Tchem 15 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

abnormal gait 2 | 69
cataract 2 | 92
increased lean body mass 2 | 172
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal gallbladder morpholog... 1 | 1
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 23 | 11,493
osteosarcoma 17 | 7,950
psoriasis 16 | 6,694
lung cancer 15 | 4,740
ovarian cancer 13 | 8,520
ependymoma 11 | 4,679
glioblastoma 10 | 5,792
interstitial cystitis 10 | 2,312
lung carcinoma 10 | 2,843
medulloblastoma, large-cell 10 | 6,241
Kidney cancer 9 | 2,613
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
Astrocytoma, Pilocytic 7 | 3,081
Breast cancer 7 | 3,578
Schizophrenia 7 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pancreatic cancer 7 | 2,398
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Cancer 6 | 2,499
colon cancer 6 | 1,478
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
ulcerative colitis 6 | 1,819
Melanoma 5 | 711
active Crohn's disease 5 | 922
adrenocortical carcinoma 5 | 1,428
invasive ductal carcinoma 5 | 2,951
pituitary cancer 5 | 1,972
Toxic encephalopathy 4 | 141
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Arthritis 3 | 290
Atherosclerosis 3 | 291
Coronary artery disease 3 | 268
Epilepsy 3 | 792
Infantile onset 3 | 238
Liver Cirrhosis, Experimental 3 | 769
Muscle Spasticity 3 | 195
Progressive disorder 3 | 142
Skin cancer 3 | 469
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
cystic fibrosis and chronic rhinosinusitis 3 | 214
esophageal adenocarcinoma 3 | 737
pancreatic carcinoma 3 | 562
Acute pancreatitis 2 | 10
Arthritis, Rheumatoid 2 | 174
Cardiomegaly 2 | 116
Cerebellar Dysmetria 2 | 56
Childhood onset 2 | 38
Depressive disorder 2 | 409
Dysarthria 2 | 192
Dystonia 2 | 164
Dystonic disease 2 | 106
Essential Hypertension 2 | 94
Gas gangrene 2 | 17
Hyperreflexia 2 | 209
Ileocolitis 2 | 5
Liver cancer 2 | 604
MAJOR AFFECTIVE DISORDER 2 2 | 22
Muscle hypotonia 2 | 571
Nephrotic Syndrome 2 | 78
Neurodegeneration with brain iron accumulation 2 | 20
Osteoarthritis 2 | 184
Pick disease 2 | 1,894
Proteinuria 2 | 144
Rheumatoid arthritis 2 | 1,191
active ulcerative colitis 2 | 764
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
nasopharyngeal carcinoma 2 | 1,058
non diabetic and post-ischemic heart failure 2 | 200
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung carcinoma 2 | 317
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
type II diabetes mellitus and post-ischemic heart failure 2 | 88
urothelial carcinoma 2 | 318
Asthma, Occupational 1 | 10
Autosomal recessive congenital ichthyosis 4B 1 | 13
Blepharitis 1 | 23
Blood Platelet Disorders 1 | 3
Cellulitis of eyelid 1 | 17
Cryptococcosis 1 | 18
Pneumonia, Interstitial 1 | 5

Tissue

Digestive Tract 36 | 17,369
Blood and immune system 35 | 16,909
Female tissues 35 | 17,400
Skin and soft tissues 35 | 17,230
Endocrine System 34 | 18,159
Urinary Tract 34 | 16,678
Male tissues 33 | 17,142
Liver and Pancreas 32 | 16,750
Respiratory system 32 | 16,393
Nervous System 31 | 16,725
Cardiovascular System 30 | 15,192

Target Family

Enzyme 35 | 4,145
Non-IDG 2 | 12,091

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 25 | 25
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http://pathwaycommons.org/pc2/... 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.17969 140.9 120
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Group IIE secretory phospholipase A2 PLA2G2E Tchem Enzyme -0.44734 2.04 30
Cytosolic phospholipase A2 delta PLA2G4D Tbio Enzyme -0.54284 3.41 45
Phospholipase A2, membrane associated PLA2G2A Tchem Enzyme -2.83666 743.3 137
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 PLCH2 Tbio Enzyme -0.80178 6.81 5
Phospholipase D3 PLD3 Tbio Enzyme -1.77419 62.1 99
Group IIF secretory phospholipase A2 PLA2G2F Tchem Enzyme -0.17609 1.39 2
Calcium-dependent phospholipase A2 PLA2G5 Tchem Enzyme -1.38065 26.2 137