Development Level

Tbio 17 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal lens morphology 1 | 81
abnormal tibia morphology 1 | 14
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
increased circulating bilirubi... 1 | 16
increased grip strength 1 | 41
increased heart weight 1 | 62
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

Carcinoma 14 | 11,493
ovarian cancer 12 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
medulloblastoma, large-cell 9 | 6,241
lung cancer 7 | 4,740
osteosarcoma 7 | 7,950
Multiple myeloma 6 | 1,332
Muscle hypotonia 6 | 571
astrocytoma 6 | 1,146
atypical teratoid / rhabdoid tumor 6 | 5,112
interstitial cystitis 6 | 2,312
psoriasis 6 | 6,694
colon cancer 5 | 1,478
glioblastoma 5 | 5,792
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
ulcerative colitis 5 | 1,819
Autosomal recessive predisposition 4 | 1,442
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
adult high grade glioma 4 | 3,801
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
tuberculosis 4 | 2,010
Acidosis, Lactic 3 | 97
Adrenoleukodystrophy 3 | 29
Arthritis, Experimental 3 | 39
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Breast cancer 3 | 3,578
Cardiomyopathy, Dilated 3 | 83
Dull intelligence 3 | 645
Hypoglycemia 3 | 152
Hypoketotic hypoglycemia 3 | 11
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Lactic acidemia 3 | 95
Low intelligence 3 | 645
Medium chain acyl-CoA dehydrogenase deficiency 3 | 13
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Myoglobinuria 3 | 15
Obesity 3 | 678
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Very long chain acyl-CoA dehydrogenase deficiency 3 | 10
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
beta-ketothiolase deficiency 3 | 13
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
primitive neuroectodermal tumor 3 | 3,035
Adenocarcinoma of lung 2 | 142
Alzheimer's disease 2 | 658
Cerebrovascular disease 2 | 238
Chronic intestinal vascular insufficiency 2 | 12
Coronary artery disease 2 | 268
Degenerative polyarthritis 2 | 115
Down syndrome 2 | 499
Elevated hepatic transaminases 2 | 81
Failure to gain weight 2 | 365
Generalized muscle weakness 2 | 57
Hepatic enzyme increased 2 | 81
Lactic acidosis 2 | 51
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low Birth Weights 2 | 69
Muscle Spasticity 2 | 195
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Osteoarthritis 2 | 184
Pediatric failure to thrive 2 | 365
Proteinuria 2 | 144
Psychotic Disorders 2 | 151
Rhabdomyolysis 2 | 15
Schizophrenia 2 | 1,160
Small for gestational age (disorder) 2 | 69
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Waldenstrons macroglobulinemia 2 | 765
Zellweger syndrome 2 | 37
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
aldosterone-producing adenoma 2 | 665
chronic rhinosinusitis 2 | 512
gastric cancer 2 | 459
lung adenocarcinoma 2 | 2,716
nasopharyngeal carcinoma 2 | 1,058
nephrosclerosis 2 | 333
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972

Tissue

Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Nervous System 18 | 16,725
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Respiratory system 17 | 16,393
Cardiovascular System 16 | 15,192

Target Family

Enzyme 15 | 4,145
Non-IDG 2 | 12,091
Transporter 1 | 473

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 18 | 18
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.86749 73.8 139
Long-chain-fatty-acid--CoA ligase 4 ACSL4 Tbio Enzyme -1.88239 83.9 249
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH Tbio Enzyme -2.48697 296.4 389
Peroxisomal bifunctional enzyme EHHADH Tbio Non-IDG -2.05616 109.3 204
Long-chain-fatty-acid--CoA ligase 1 ACSL1 Tbio Enzyme -2.59850 388.5 222
Enoyl-CoA delta isomerase 2, mitochondrial ECI2 Tbio Enzyme -1.42783 24.0 174
Very long-chain acyl-CoA synthetase SLC27A2 Tbio Transporter -1.73251 54.7 121
Long-chain-fatty-acid--CoA ligase 3 ACSL3 Tbio Enzyme -1.53077 28.8 152
3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Tbio Enzyme -2.13468 132.4 359