Development Level

Tbio 43 | 11,445
Tchem 22 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
decreased body weight 3 | 161
embryonic growth retardation 3 | 106
increased lean body mass 3 | 172
abnormal gait 2 | 69
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
persistence of hyaloid vascula... 2 | 33
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal gallbladder morpholog... 1 | 1
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 58 | 11,493
osteosarcoma 38 | 7,950
ovarian cancer 35 | 8,520
medulloblastoma, large-cell 30 | 6,241
glioblastoma 28 | 5,792
ependymoma 26 | 4,679
lung cancer 26 | 4,740
psoriasis 25 | 6,694
atypical teratoid / rhabdoid tumor 22 | 5,112
Kidney cancer 21 | 2,613
adult high grade glioma 21 | 3,801
lung carcinoma 18 | 2,843
group 3 medulloblastoma 17 | 4,104
Astrocytoma, Pilocytic 16 | 3,081
primitive neuroectodermal tumor 16 | 3,035
Breast cancer 14 | 3,578
subependymal giant cell astrocytoma 13 | 2,287
Autosomal recessive predisposition 12 | 1,442
Schizophrenia 12 | 1,160
malignant mesothelioma 12 | 3,232
oligodendroglioma 12 | 2,850
ulcerative colitis 12 | 1,819
Cancer 11 | 2,499
interstitial cystitis 11 | 2,312
invasive ductal carcinoma 11 | 2,951
group 4 medulloblastoma 10 | 1,855
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
Pick disease 9 | 1,894
astrocytic glioma 9 | 2,597
colon cancer 9 | 1,478
diabetes mellitus 9 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
tuberculosis 9 | 2,010
Oculocerebrorenal syndrome 8 | 29
pituitary cancer 8 | 1,972
primary Sjogren syndrome 8 | 735
astrocytoma 7 | 1,146
pancreatic cancer 7 | 2,398
Bipolar Disorder 6 | 666
Cataract 6 | 297
Epilepsy 6 | 792
Frontal bossing 6 | 157
Liver cancer 6 | 604
Melanoma 6 | 711
Waldenstrons macroglobulinemia 6 | 765
cutaneous lupus erythematosus 6 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
spina bifida 6 | 1,074
Centronuclear myopathy 5 | 27
DOID:2627 5 | 94
Hypoplastic mandible condyle 5 | 275
Intellectual disability 5 | 1,016
Lens Opacities 5 | 231
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Orbital separation excessive 5 | 244
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
atypical teratoid/rhabdoid tumor 5 | 357
breast carcinoma 5 | 1,638
Acquired scoliosis 4 | 281
Big calvaria 4 | 147
Cognitive delay 4 | 608
Concave bridge of nose 4 | 195
Curvature of spine 4 | 282
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Global developmental delay 4 | 608
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Long narrow head 4 | 75
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Narrow cranium shape 4 | 75
Narrow head shape 4 | 75
Narrow skull shape 4 | 75
Parkinson's disease 4 | 392
Polymicrogyria 4 | 48
Poor school performance 4 | 645
Progressive disorder 4 | 142
Skin cancer 4 | 469
Turridolichocephaly 4 | 75
active Crohn's disease 4 | 922
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 807
medulloblastoma 4 | 720
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962

Tissue

Digestive Tract 68 | 17,369
Endocrine System 68 | 18,159
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Skin and soft tissues 68 | 17,230
Blood and immune system 67 | 16,909
Male tissues 67 | 17,142
Nervous System 67 | 16,725
Respiratory system 67 | 16,393
Urinary Tract 67 | 16,678
Cardiovascular System 66 | 15,192

Target Family

Enzyme 38 | 4,145
Kinase 28 | 634
Non-IDG 2 | 12,091

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Synaptojanin-2 SYNJ2 Tbio Non-IDG -1.15573 16.3 157
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.17969 140.9 120
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 PPIP5K2 Tbio Enzyme -1.29036 17.0 49
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 PLCH2 Tbio Enzyme -0.80178 6.81 5
Inositol polyphosphate multikinase IPMK Tbio Kinase -1.55144 39.0 159
Inositol-trisphosphate 3-kinase B ITPKB Tchem Kinase -1.44569 29.5 168
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104