Development Level

Tbio 9 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal tibia morphology 1 | 14
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210
increased circulating bilirubi... 1 | 16
increased grip strength 1 | 41
increased heart weight 1 | 62
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

Carcinoma 9 | 11,493
medulloblastoma, large-cell 7 | 6,241
ovarian cancer 7 | 8,520
atypical teratoid / rhabdoid tumor 5 | 5,112
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Adrenoleukodystrophy 4 | 29
Atopic dermatitis 4 | 952
glioblastoma 4 | 5,792
group 3 medulloblastoma 4 | 4,104
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Arthritis, Experimental 3 | 39
Astrocytoma, Pilocytic 3 | 3,081
Breast cancer 3 | 3,578
Kidney cancer 3 | 2,613
Peroxisomal disease 3 | 22
active Crohn's disease 3 | 922
adult high grade glioma 3 | 3,801
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
interstitial cystitis 3 | 2,312
malignant mesothelioma 3 | 3,232
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Cerebrovascular disease 2 | 238
Chronic intestinal vascular insufficiency 2 | 12
Coronary artery disease 2 | 268
Down syndrome 2 | 499
Muscle hypotonia 2 | 571
Refsum disease 2 | 20
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Severe mental retardation (I.Q. 20-34) 2 | 99
active ulcerative colitis 2 | 764
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
gastric cancer 2 | 459
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
Abnormal skeletal development 1 | 60
Abnormality of metabolism/homeostasis 1 | 134
Abnormality of retinal pigmentation 1 | 111
Adenocarcinoma of lung 1 | 142
Blepharoptosis 1 | 231
Cardiac Arrhythmia 1 | 103
Cardiac conduction abnormalities 1 | 78
Cardiomyopathies 1 | 110
Chemical and Drug Induced Liver Injury 1 | 195
Chondrodysplasia punctata 1 | 41
Conduction disorder of the heart 1 | 79
Congenital deafness 1 | 185
Congenital pes cavus 1 | 88
Congestive heart failure 1 | 113
Deafness 1 | 198
Decreased tendon reflex 1 | 122
Difficulties with night vision 1 | 87
Disease Models, Animal 1 | 155
Downward slant of palpebral fissure 1 | 158
EKG abnormalities 1 | 78
Electrocardiogram abnormal 1 | 81
Electrocardiogram change 1 | 78
Elevated levels of phytanic acid 1 | 15
Hearing Loss, Partial 1 | 185
Heart failure 1 | 162
Ichthyoses 1 | 41
Infantile Refsum disease 1 | 23
Liver Cirrhosis, Experimental 1 | 769
Low Vision 1 | 174
Lymphoma 1 | 81
Nail dysplasia 1 | 52
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Neuropathy 1 | 261
Night Blindness 1 | 101
Osteochondrodysplasias 1 | 72
Peripheral sensorimotor neuropathy 1 | 16
Proteinuria 1 | 144
Retinal Degeneration 1 | 106
Retinal Diseases 1 | 55
Retinal pigment epithelial abnormality 1 | 111
Sensorineural Hearing Loss (disorder) 1 | 284
Skeletal muscle atrophy 1 | 139
Tapering fingers (finding) 1 | 25
Visual Impairment 1 | 174
Zellweger syndrome 1 | 37
alpha-methylacyl-CoA racemase deficiency 1 | 9
hearing impairment 1 | 199
hereditary spastic paraplegia 1 | 318
muscle degeneration 1 | 139

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Nervous System 10 | 16,725
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Respiratory system 9 | 16,393
Cardiovascular System 8 | 15,192

Target Family

Enzyme 9 | 4,145
Transporter 1 | 473

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.86749 73.8 139
Long-chain-fatty-acid--CoA ligase 4 ACSL4 Tbio Enzyme -1.88239 83.9 249
Long-chain-fatty-acid--CoA ligase 1 ACSL1 Tbio Enzyme -2.59850 388.5 222
Very long-chain acyl-CoA synthetase SLC27A2 Tbio Transporter -1.73251 54.7 121
Long-chain-fatty-acid--CoA ligase 3 ACSL3 Tbio Enzyme -1.53077 28.8 152
2-hydroxyacyl-CoA lyase 1 HACL1 Tbio Enzyme -1.82472 63.8 159
Long-chain-fatty-acid--CoA ligase ACSBG2 ACSBG2 Tdark Enzyme -0.38371 2.13 98
Phytanoyl-CoA dioxygenase, peroxisomal PHYH Tbio Enzyme -2.34936 221.5 300
Long-chain-fatty-acid--CoA ligase ACSBG1 ACSBG1 Tbio Enzyme -2.36014 218.3 88