Development Level

Tbio 10 | 11,445
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal lens morphology 1 | 81
abnormal tibia morphology 1 | 14
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
thrombocytopenia 1 | 56

Disease

Carcinoma 9 | 11,493
medulloblastoma, large-cell 8 | 6,241
psoriasis 8 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
lung cancer 6 | 4,740
ovarian cancer 6 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Breast cancer 5 | 3,578
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
osteosarcoma 5 | 7,950
pancreatic cancer 5 | 2,398
Adrenoleukodystrophy 4 | 29
active Crohn's disease 4 | 922
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
oligodendroglioma 4 | 2,850
tuberculosis 4 | 2,010
Arthritis, Experimental 3 | 39
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Kidney cancer 3 | 2,613
cystic fibrosis 3 | 1,696
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Diabetes Mellitus, Experimental 2 | 108
Down syndrome 2 | 499
Obesity 2 | 678
Peroxisomal disease 2 | 22
Rheumatoid arthritis 2 | 1,191
active ulcerative colitis 2 | 764
aldosterone-producing adenoma 2 | 665
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 459
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
Adenocarcinoma of lung 1 | 142
Animal Mammary Neoplasms 1 | 136
Anteverted nostril 1 | 191
Attention deficit hyperactivity disorder 1 | 278
Carcinoma, Hepatocellular 1 | 228
Cerebrovascular disease 1 | 238
Chronic intestinal vascular insufficiency 1 | 12
Chronic obstructive pulmonary disease 1 | 184
Concave bridge of nose 1 | 195
Congenital deafness 1 | 185
Coronary artery disease 1 | 268
Deafness 1 | 198
Depressed nasal bridge 1 | 195
Depressed nasal root/bridge 1 | 195
Depressive disorder 1 | 409
Disease Models, Animal 1 | 155
Downward slant of palpebral fissure 1 | 158
Hearing Loss, Partial 1 | 185
Heart failure 1 | 162
Hepatomegaly 1 | 285
Ichthyosis 1 | 56
Kidney Failure 1 | 111
Liver Cirrhosis, Experimental 1 | 769
Liver carcinoma 1 | 240
Liver neoplasms 1 | 130
Meckel's diverticulum 1 | 5
Myocardial Ischemia 1 | 169
Pick disease 1 | 1,894
Proteinuria 1 | 144
Renal Insufficiency 1 | 90
Renal failure in adulthood 1 | 76
Severe mental retardation (I.Q. 20-34) 1 | 99
Tapering fingers (finding) 1 | 25
Thin lips 1 | 49
acute quadriplegic myopathy 1 | 1,158
adrenocortical carcinoma 1 | 1,428
astrocytoma 1 | 1,146
chronic rhinosinusitis 1 | 512
colon cancer 1 | 1,478
esophageal adenocarcinoma 1 | 737
glioblastoma multiforme 1 | 142
hearing impairment 1 | 199
hereditary spastic paraplegia 1 | 318
juvenile dermatomyositis 1 | 1,187
mucosa-associated lymphoid tissue lymphoma 1 | 484
nephrosclerosis 1 | 333
non diabetic and post-ischemic heart failure 1 | 200
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972
primary pancreatic ductal adenocarcinoma 1 | 1,109
tuberculosis and treatment for 3 months 1 | 179

Tissue

Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Nervous System 13 | 16,725
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Respiratory system 12 | 16,393
Cardiovascular System 11 | 15,192

Target Family

Enzyme 10 | 4,145
Non-IDG 2 | 12,091
Transporter 1 | 473

PathwayCommons: humancyc Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Acyl-coenzyme A thioesterase 4 ACOT4 Tbio Enzyme -0.53787 2.87 58
Acyl-coenzyme A thioesterase 1 ACOT1 Tdark Enzyme -2.14311 129.6 43
Elongation of very long chain fatty acids protein 1 ELOVL1 Tbio Non-IDG -1.29305 16.7 156
Elongation of very long chain fatty acids protein 6 ELOVL6 Tchem Non-IDG -1.88496 74.1 147
Long-chain-fatty-acid--CoA ligase 4 ACSL4 Tbio Enzyme -1.88239 83.9 249
Long-chain-fatty-acid--CoA ligase 1 ACSL1 Tbio Enzyme -2.59850 388.5 222
Very long-chain acyl-CoA synthetase SLC27A2 Tbio Transporter -1.73251 54.7 121
Cytosolic acyl coenzyme A thioester hydrolase ACOT7 Tbio Enzyme -2.06780 111.8 102
Long-chain-fatty-acid--CoA ligase 3 ACSL3 Tbio Enzyme -1.53077 28.8 152