Development Level

Tchem 6 | 1,598
Tbio 5 | 11,445
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
microphthalmia 2 | 26
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
anophthalmia 1 | 33
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
increased body length 1 | 32
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

Carcinoma 8 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
malignant mesothelioma 7 | 3,232
ovarian cancer 7 | 8,520
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Multiple myeloma 4 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
Autosomal recessive predisposition 3 | 1,442
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Pick disease 3 | 1,894
Porokeratosis of Mibelli 3 | 4
Seizures 3 | 596
active Crohn's disease 3 | 922
beta-ketothiolase deficiency 3 | 13
chronic rhinosinusitis 3 | 512
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
Aplasia/Hypoplasia of the skin 2 | 16
Breast cancer 2 | 3,578
Carcinoma, Hepatocellular 2 | 228
Disseminated superficial actinic porokeratosis 2 | 4
Dull intelligence 2 | 645
Elevated hepatic transaminases 2 | 81
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Hepatic enzyme increased 2 | 81
Hydrolethalus syndrome 2 | 128
Hyperkeratosis 2 | 50
Intellectual disability 2 | 1,016
Keratosis 2 | 37
Kidney Failure, Chronic 2 | 46
Liver Cirrhosis, Experimental 2 | 769
Liver Dysfunction 2 | 99
Liver carcinoma 2 | 240
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Myalgia 2 | 54
Pediatric failure to thrive 2 | 365
Photosensitivity of skin 2 | 51
Poor school performance 2 | 645
Porokeratosis, Disseminated Superficial Actinic 2 | 4
Pruritus 2 | 58
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Vomiting 2 | 116
Waldenstrons macroglobulinemia 2 | 765
Zellweger syndrome 2 | 37
active ulcerative colitis 2 | 764
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
nephrosclerosis 2 | 333
pancreatic cancer 2 | 2,398
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
Blue sclera 1 | 32
Carnitine palmitoyltransferase II deficiency 1 | 14
Chromosome Breakage 1 | 36
Dehydration 1 | 40
Edema 1 | 81
Exanthema 1 | 43
Fatty Liver 1 | 70
Fatty liver disease 1 | 103
Gaucher's disease 1 | 26
Heart Diseases 1 | 43
Hydrops Fetalis 1 | 21
Hyperlipidemia 1 | 43
Hyperpigmented macules 1 | 42
Hypertriglyceridemia 1 | 17
Hypoparathyroidism 1 | 41
Increased chromosomal breakage 1 | 27
Increased serum pyruvate 1 | 9
Intermittent fever 1 | 15
Intermittent migraine headaches 1 | 68
Lymphadenopathy 1 | 62
Malignant neoplasm of skin 1 | 15
Migraine Disorders 1 | 76
Mitral valve insufficiency 1 | 49
Multiple system atrophy 1 | 29
POROKERATOSIS 7, MULTIPLE TYPES 1 | 1
Pallor of optic disc 1 | 39
Peripheral Neuropathy 1 | 134
Progressive cerebellar ataxia 1 | 13
Skin Neoplasms 1 | 69
Very long chain acyl-CoA dehydrogenase deficiency 1 | 10
Waterhouse-Friderichsen syndrome 1 | 11
interstitial lung disease 1 | 298

Tissue

Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Skin and soft tissues 12 | 17,230
Blood and immune system 11 | 16,909
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Respiratory system 11 | 16,393
Urinary Tract 11 | 16,678

Target Family

Enzyme 11 | 4,145
Kinase 1 | 634

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Phosphomevalonate kinase PMVK Tchem Enzyme -1.96385 92.3 144
Acetyl-CoA acetyltransferase, cytosolic ACAT2 Tbio Enzyme -1.75917 52.6 283
Isopentenyl-diphosphate delta-isomerase 2 IDI2 Tbio Enzyme -1.25123 20.8 84
Isopentenyl-diphosphate Delta-isomerase 1 IDI1 Tchem Enzyme -1.60998 38.3 124
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
3-ketoacyl-CoA thiolase, peroxisomal ACAA1 Tbio Enzyme -2.31883 203.8 197
Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Tchem Enzyme -1.85518 70.4 397