Development Level

Tbio 7 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

abnormal embryo size 2 | 220
abnormal seminal vesicle morph... 2 | 114
microphthalmia 2 | 26
abnormal body wall morphology 1 | 9
abnormal heart morphology 1 | 162
abnormal sensory capabilities-... 1 | 8
anophthalmia 1 | 33
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating lipase l... 1 | 3
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased monocyte cell number 1 | 63
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 10 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
ovarian cancer 5 | 8,520
Autosomal recessive predisposition 4 | 1,442
Pellagra 4 | 26
ductal carcinoma in situ 4 | 1,745
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
psoriasis 4 | 6,694
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Liver Cirrhosis, Experimental 3 | 769
Major Depressive Disorder 3 | 301
Mental and motor retardation 3 | 608
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Unipolar Depression 3 | 250
Waldenstrons macroglobulinemia 3 | 765
beta-ketothiolase deficiency 3 | 13
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
osteosarcoma 3 | 7,950
primary Sjogren syndrome 3 | 735
ulcerative colitis 3 | 1,819
Breast cancer 2 | 3,578
Dull intelligence 2 | 645
Failure to gain weight 2 | 365
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Metabolic acidosis 2 | 90
Pediatric failure to thrive 2 | 365
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Vomiting 2 | 116
active ulcerative colitis 2 | 764
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
cystic fibrosis 2 | 1,696
gastric carcinoma 2 | 807
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
nephrosclerosis 2 | 333
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
tuberculosis 2 | 2,010
Abnormal urinary amino-acid findings 1 | 38
Aminoaciduria 1 | 38
Big calvaria 1 | 147
Breast Neoplasms 1 | 445
Cardiomyopathy 1 | 116
Carnitine palmitoyltransferase II deficiency 1 | 14
Chondrodysplasia punctata 1 | 41
Comatose 1 | 56
Congenital deafness 1 | 185
Congestive heart failure 1 | 113
Corneal dystrophy 1 | 24
Deafness 1 | 198
Dehydration 1 | 40
Delayed myelination 1 | 22
Depressed mood 1 | 17
Encephalopathies 1 | 43
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Fatty Liver 1 | 70
Gaucher's disease 1 | 26
Generalized muscle weakness 1 | 57
Gilles de la Tourette syndrome 1 | 47
Hearing Loss, Partial 1 | 185
Heart failure 1 | 162
Hyperammonemia 1 | 30
Increased head circumference 1 | 147
Increased serum lactate 1 | 60
Increased serum pyruvate 1 | 9
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Inflammation 1 | 120
Ketonemia 1 | 11
Ketosis 1 | 11
Mammary Neoplasms 1 | 425
Muscle Rigidity 1 | 49
Narcolepsy 1 | 72
Neurodegenerative Disorders 1 | 79
Nonorganic psychosis 1 | 84
Organic acidemia 1 | 4
Peripheral Neuropathy 1 | 134
Respiratory Failure 1 | 104
Very long chain acyl-CoA dehydrogenase deficiency 1 | 10
Zellweger syndrome 1 | 37
hearing impairment 1 | 199

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192
Skin and soft tissues 10 | 17,230

Target Family

Enzyme 11 | 4,145

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 25 | 25
http://pathwaycommons.org/pc2/... 23 | 23
http://pathwaycommons.org/pc2/... 22 | 22
http://pathwaycommons.org/pc2/... 22 | 22
http://pathwaycommons.org/pc2/... 21 | 21
http://pathwaycommons.org/pc2/... 20 | 20
http://pathwaycommons.org/pc2/... 20 | 20
http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 18 | 18
http://pathwaycommons.org/pc2/... 16 | 16
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
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http://pathwaycommons.org/pc2/... 13 | 13
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http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
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http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
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http://pathwaycommons.org/pc2/... 8 | 8
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http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
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http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
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http://pathwaycommons.org/pc2/... 6 | 6
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http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
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http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 5 | 5
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http://pathwaycommons.org/pc2/... 5 | 5
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http://pathwaycommons.org/pc2/... 5 | 5
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http://pathwaycommons.org/pc2/... 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kynureninase KYNU Tchem Enzyme -1.61116 39.2 173
Kynurenine formamidase AFMID Tbio Enzyme -1.65562 44.8 67
3-hydroxyanthranilate 3,4-dioxygenase HAAO Tbio Enzyme -1.76359 56.1 114
Acetyl-CoA acetyltransferase, cytosolic ACAT2 Tbio Enzyme -1.75917 52.6 283
Kynurenine 3-monooxygenase KMO Tchem Enzyme -2.15501 134.1 127
Tryptophan 2,3-dioxygenase TDO2 Tchem Enzyme -2.89113 773.6 193
3-ketoacyl-CoA thiolase, peroxisomal ACAA1 Tbio Enzyme -2.31883 203.8 197
Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Tchem Enzyme -1.85518 70.4 397
Glutaryl-CoA dehydrogenase, mitochondrial GCDH Tbio Enzyme -2.52555 327.8 181
Trifunctional enzyme subunit beta, mitochondrial HADHB Tbio Enzyme -2.05645 118.4 185