Development Level

Tbio 5 | 11,445

IMPC Phenotype

abnormal lens morphology 1 | 81
abnormal vitreous body morphol... 1 | 10
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979

Disease

Erythropoietic protoporphyria 5 | 15
Acute intermittent porphyria 4 | 15
Hereditary coproporphyria 4 | 8
Porphyria 4 | 10
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Anemia 3 | 365
Carcinoma 3 | 11,493
Porphyria cutanea tarda 3 | 12
Variegate Porphyria 3 | 10
medulloblastoma, large-cell 3 | 6,241
Abdominal Pain 2 | 98
Anemia, Hemolytic 2 | 55
Autosomal recessive predisposition 2 | 1,442
Constipation 2 | 181
Cutaneous porphyria 2 | 6
Diarrhea 2 | 253
Dyschezia 2 | 135
Elevated urinary delta-aminolevulinic acid 2 | 3
Hypertensive disease 2 | 292
Muscle Weakness 2 | 170
Paresthesia 2 | 32
Photosensitivity of skin 2 | 51
Respiratory Paralysis 2 | 7
Seizures 2 | 596
Sideroblastic anemia 2 | 20
Urine color abnormal 2 | 6
Vomiting 2 | 116
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
Abnormal blistering of the skin 1 | 54
Anemia, Macrocytic 1 | 18
Anemia, Sideroblastic 1 | 7
Anorexia 1 | 43
Anxiety 1 | 136
Anxiety disease 1 | 113
Atypical scarring of skin 1 | 62
Blister of skin 1 | 54
Carcinoma, Renal Cell 1 | 124
Childhood onset 1 | 38
Cholelithiasis 1 | 33
Collapse of vertebra 1 | 14
Compression fracture of vertebral column 1 | 14
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Contracture of joint of hand 1 | 30
Corneal Scar 1 | 7
Decreased platelet count 1 | 111
Diffusely thickened skin 1 | 20
Disorders of Porphyrin Metabolism 1 | 1
Elevated heart rate 1 | 25
Fatigue 1 | 182
Generalized osteopenia 1 | 99
Genetic Predisposition to Disease 1 | 27
Hand deformities 1 | 32
Hyperhidrosis disorder 1 | 81
Hyperpigmentation 1 | 37
Hypertrichosis 1 | 46
Hypopigmentation disorder 1 | 25
Immunologic Deficiency Syndromes 1 | 113
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Increased sweating 1 | 81
Inverted follicular keratosis 1 | 3
Lead Poisoning 1 | 6
Liver Neoplasms, Experimental 1 | 59
Lytic lesion 1 | 32
Meningioma 1 | 41
Microcytic hypochromic anemia (disorder) 1 | 10
Mouth Abnormalities 1 | 14
Myalgia 1 | 54
Nausea 1 | 20
Nausea and vomiting 1 | 97
Osteopenia 1 | 99
Pachyderma 1 | 20
Pallor 1 | 40
Paralytic ileus 1 | 5
Pathological fracture 1 | 20
Peripheral Neuropathy 1 | 134
Polyneuropathy 1 | 64
Porphyrias 1 | 1
Recurrent skin infections 1 | 21
Renal Cell Carcinoma 1 | 214
Respiratory Distress Syndrome, Adult 1 | 40
Scleroderma 1 | 7
Scleroderma-like secondary cutaneous sclerosis 1 | 7
Skin bulla 1 | 54
Sleeplessness 1 | 16
Sweating 1 | 81
Tyrosinemia 1 | 10
X- linked recessive 1 | 110
X-linked dominant 1 | 57
X-linked sideroblastic anemia 1 | 4

Tissue

Blood and immune system 5 | 16,909
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678
Cardiovascular System 4 | 15,192
Nervous System 4 | 16,725

Target Family

Enzyme 5 | 4,145

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 25 | 25
http://pathwaycommons.org/pc2/... 23 | 23
http://pathwaycommons.org/pc2/... 22 | 22
http://pathwaycommons.org/pc2/... 22 | 22
http://pathwaycommons.org/pc2/... 21 | 21
http://pathwaycommons.org/pc2/... 20 | 20
http://pathwaycommons.org/pc2/... 20 | 20
http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 18 | 18
http://pathwaycommons.org/pc2/... 16 | 16
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 14 | 14
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Porphobilinogen deaminase HMBS Tbio Enzyme -2.78202 588.5 255
5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 Tbio Enzyme -2.18341 149.7 219
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -3.02024 1068.6 166
Uroporphyrinogen-III synthase UROS Tbio Enzyme -2.48982 310.9 67