Development Level

Tbio 4 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
decreased body weight 1 | 161
embryonic lethality prior to o... 1 | 239

Disease

Carcinoma 5 | 11,493
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
medulloblastoma, large-cell 3 | 6,241
ovarian cancer 3 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
psoriasis 3 | 6,694
Cancer 2 | 2,499
Lymphoma, Non-Hodgkin 2 | 24
Schizophrenia 2 | 1,160
ductal carcinoma in situ 2 | 1,745
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
nasopharyngeal carcinoma 2 | 1,058
neural tube defect 2 | 9
Abruptio Placentae 1 | 3
Adenocarcinoma of lung 1 | 142
Adverse reaction to drug 1 | 61
Alzheimer's disease 1 | 658
Arthritis, Rheumatoid 1 | 174
Atopic dermatitis 1 | 952
Bipolar Disorder 1 | 666
Breast Neoplasms 1 | 445
Breast cancer 1 | 3,578
Campylobacteriosis 1 | 11
Carcinoma, Non-Small-Cell Lung 1 | 107
Cardiovascular system disease 1 | 246
Cleft Lip 1 | 141
Cleft Palate 1 | 271
Colorectal Neoplasms 1 | 243
Congenital heart disease 1 | 93
Disease Models, Animal 1 | 155
Drug-Related Side Effects and Adverse Reactions 1 | 62
Homocystinuria 1 | 21
Hyperhomocysteinemia 1 | 37
Kidney cancer 1 | 2,613
Malaria 1 | 160
Mammary Neoplasms 1 | 425
Megaloblastic anemia 1 | 18
Methylmalonic acidemia 1 | 37
Multiple myeloma 1 | 1,332
Nervous System Diseases 1 | 53
Neural Tube Defects 1 | 31
Neural tube defect, folate-sensitive 1 | 4
Neural tube defects, folate-sensitive 1 | 2
Polycystic ovary syndrome 1 | 360
Potocki-Luspski syndrome 1 | 5
Precursor Cell Lymphoblastic Leukemia Lymphoma 1 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 | 49
Rheumatoid arthritis 1 | 1,191
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
acute myeloid leukemia 1 | 783
adrenocortical carcinoma 1 | 1,428
astrocytoma 1 | 1,146
colon cancer 1 | 1,478
diabetes mellitus 1 | 1,728
esophageal adenocarcinoma 1 | 737
gastric carcinoma 1 | 807
group 3 medulloblastoma 1 | 4,104
invasive ductal carcinoma 1 | 2,951
nephrosclerosis 1 | 333
nervous system disorder 1 | 53
non primary Sjogren syndrome sicca 1 | 891
non-small cell lung cancer 1 | 2,890
non-small cell lung carcinoma 1 | 317
oligodendroglioma 1 | 2,850
osteosarcoma 1 | 7,950
pediatric high grade glioma 1 | 1,064
posterior fossa group A ependymoma 1 | 468
primary Sjogren syndrome 1 | 735
spina bifida 1 | 1,074
tuberculosis 1 | 2,010

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
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http://pathwaycommons.org/pc2/... 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Folylpolyglutamate synthase, mitochondrial FPGS Tchem Enzyme -1.90018 79.8 131
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.66972 40.2 102
Serine hydroxymethyltransferase, cytosolic SHMT1 Tbio Enzyme -2.58690 370.4 181
Serine hydroxymethyltransferase, mitochondrial SHMT2 Tbio Enzyme -2.39227 240.3 137