Development Level

Tbio 5 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
edema 1 | 59
increased circulating bilirubi... 1 | 16
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
thrombocytopenia 1 | 56

Disease

psoriasis 5 | 6,694
Cancer 4 | 2,499
Carcinoma 4 | 11,493
non-small cell lung cancer 4 | 2,890
Autosomal recessive predisposition 3 | 1,442
Carcinoma, Non-Small-Cell Lung 3 | 107
Epilepsy 3 | 792
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Seizures 3 | 596
Serine deficiency 3 | 9
colon cancer 3 | 1,478
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
nasopharyngeal carcinoma 3 | 1,058
non-small cell lung carcinoma 3 | 317
oligodendroglioma 3 | 2,850
osteosarcoma 3 | 7,950
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Adenocarcinoma of lung 2 | 142
Atopic dermatitis 2 | 952
Breast Neoplasms 2 | 445
Breast cancer 2 | 3,578
Cleft Palate 2 | 271
Cognitive delay 2 | 608
Disease Models, Animal 2 | 155
Dull intelligence 2 | 645
Global developmental delay 2 | 608
Hypoplastic mandible condyle 2 | 275
Infantile onset 2 | 238
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mammary Neoplasms 2 | 425
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Micrognathism 2 | 275
Muscle Hypertonia 2 | 88
Neu Laxova syndrome 2 | 2
Neu-Laxova syndrome 2 | 2
Neu-Laxova syndrome 1 2 | 2
Orbital separation excessive 2 | 244
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Reduced fetal movement 2 | 51
Schizophrenia 2 | 1,160
Short neck 2 | 140
Sloping forehead 2 | 46
Small head 2 | 374
Uranostaphyloschisis 2 | 167
Vertical Talus 2 | 25
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
atypical teratoid / rhabdoid tumor 2 | 5,112
ductal carcinoma in situ 2 | 1,745
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
ovarian cancer 2 | 8,520
pancreatic carcinoma 2 | 562
subependymal giant cell astrocytoma 2 | 2,287
Acquired metabolic disease 1 | 336
Adducted thumb 1 | 22
Campylobacteriosis 1 | 11
Cardiovascular system disease 1 | 246
Congenital Bilateral Cataracts 1 | 50
Congenital cataract 1 | 50
Exophthalmos 1 | 112
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Ichthyoses 1 | 41
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Lymphoma, Non-Hodgkin 1 | 24
Macrotia 1 | 87
Melanoma 1 | 711
Polyhydramnios 1 | 108
Poor growth 1 | 114
Prenatal onset 1 | 139
Prominent eyes 1 | 96
Prominent globes 1 | 96
Protruding eyes 1 | 96
Short cord 1 | 5
Small placenta 1 | 4
Very poor growth 1 | 114
X-linked cerebral adrenoleukodystrophy 1 | 116
atypical teratoid/rhabdoid tumor 1 | 357
posterior fossa group A ependymoma 1 | 468

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
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http://pathwaycommons.org/pc2/... 25 | 25
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http://pathwaycommons.org/pc2/... 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Serine hydroxymethyltransferase, cytosolic SHMT1 Tbio Enzyme -2.58690 370.4 181
Serine hydroxymethyltransferase, mitochondrial SHMT2 Tbio Enzyme -2.39227 240.3 137
Phosphoserine aminotransferase PSAT1 Tbio Enzyme -2.25926 176.4 136
Phosphoserine phosphatase PSPH Tbio Enzyme -1.56433 55.8 252