Development Level

Tbio 19 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
preweaning lethality, incomple... 1 | 499
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 18 | 11,493
ovarian cancer 12 | 8,520
Oculocerebrorenal syndrome 10 | 29
ependymoma 10 | 4,679
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 9 | 7,950
adult high grade glioma 8 | 3,801
lung cancer 8 | 4,740
Intellectual disability 7 | 1,016
group 3 medulloblastoma 7 | 4,104
oligodendroglioma 7 | 2,850
Kidney cancer 6 | 2,613
atypical teratoid / rhabdoid tumor 6 | 5,112
glioblastoma 6 | 5,792
Astrocytoma, Pilocytic 5 | 3,081
Pick disease 5 | 1,894
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
primitive neuroectodermal tumor 5 | 3,035
psoriasis 5 | 6,694
Acquired scoliosis 4 | 281
Autosomal recessive predisposition 4 | 1,442
Breast cancer 4 | 3,578
Cataract 4 | 297
Curvature of spine 4 | 282
Dull intelligence 4 | 645
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
lung carcinoma 4 | 2,843
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Centronuclear myopathy 3 | 27
Cognitive delay 3 | 608
Epilepsy 3 | 792
Frontal bossing 3 | 157
Global developmental delay 3 | 608
Lens Opacities 3 | 231
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Parkinson's disease 3 | 392
Seizures 3 | 596
active Crohn's disease 3 | 922
astrocytoma 3 | 1,146
gastric carcinoma 3 | 807
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
Amblyopia 2 | 38
Big calvaria 2 | 147
Breast Neoplasms 2 | 445
Cancer 2 | 2,499
Cardiovascular system disease 2 | 246
Cerebellar Ataxia 2 | 304
Concave bridge of nose 2 | 195
Delayed speech and language development 2 | 112
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Dysarthria 2 | 192
Hypertension 2 | 396
Hypertensive disease 2 | 292
Impaired cognition 2 | 96
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Kyphosis deformity of spine 2 | 114
Language Delay 2 | 112
Liver Cirrhosis, Experimental 2 | 769
Long narrow head 2 | 75
Long philtrum 2 | 137
Lymphatic obstruction 2 | 21
Lymphedema 2 | 42
Mammary Neoplasms 2 | 425
Mental impairment 2 | 95
Narrow cranium shape 2 | 75
Narrow head shape 2 | 75
Narrow skull shape 2 | 75
Neurodegenerative disease 2 | 414
Nystagmus 2 | 317
Onset of lymphedema around puberty 2 | 21
Orbital separation excessive 2 | 244
Range of joint movement increased 2 | 32
Reperfusion Injury 2 | 86
Short nose 2 | 132
Short stature 2 | 531
Small nose 2 | 132
Speech Delay 2 | 112
Speech impairment 2 | 112
Turridolichocephaly 2 | 75
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
fibroadenoma 2 | 559
glioblastoma multiforme 2 | 142
non-small cell lung cancer 2 | 2,890

Tissue

Blood and immune system 21 | 16,909
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Cardiovascular System 20 | 15,192
Liver and Pancreas 20 | 16,750
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Enzyme 19 | 4,145
Non-IDG 2 | 12,091

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 21 | 21
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 PTPMT1 Tbio Enzyme -1.36243 23.0 109
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12941 13.9 47
Synaptojanin-2 SYNJ2 Tbio Non-IDG -1.15573 16.3 157
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
Type II inositol 1,4,5-trisphosphate 5-phosphatase INPP5B Tbio Enzyme -1.53163 29.3 109
Type II inositol 3,4-bisphosphate 4-phosphatase INPP4B Tbio Enzyme -1.55176 41.6 79
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 INPPL1 Tchem Enzyme -2.05056 144.2 215
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
Phosphatidylinositide phosphatase SAC1 SACM1L Tbio Enzyme -2.04383 109.7 89